DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and CASR

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001171536.2	Gene:	CASR / 846	HGNCID:	1514	Length:	1088	Species:	Homo sapiens

Alignment Length:	1241	Identity:	244/1241 - (19%)
Similarity:	402/1241 - (32%)	Gaps:	413/1241 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PAEMQRNHGKIVLLGLFEL-------STSRGPRPD----------GLSELGAATMAVEHINRK-R 189
            |.:..:..|.|:|.|||.:       ......||:          |...|.|...|:|.||.. .
Human    22 PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPA 86

  Fly   190 LLPGYTLELVTNDTQCD------------------PGVGVDRFFHAIYTQPSTRMVMLLGSACSE 236
            |||..||.....|| |:                  ..:.:|.|.:.....|||  :.::|:..|.
Human    87 LLPNLTLGYRIFDT-CNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPST--IAVVGATGSG 148

  Fly   237 VTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFS 301
            |:.::|.::..:.|.|||:.|:|..||::.:|..|.||:..|.....|....|..|.|..|.|.:
Human   149 VSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIA 213

  Fly   302 QNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQL--------------LLLRETDTRIII 352
            .:::.....:.....|.|..:|         ..||.|.:              ::...|...|::
Human   214 ADDDYGRPGIEKFREEAEERDI---------CIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVV 269

  Fly   353 GSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNS 417
            .|...:|.| ::.|..|..:.|.  .|:..|:     |              |..:||.:..:..
Human   270 FSSGPDLEP-LIKEIVRRNITGK--IWLASEA-----W--------------ASSSLIAMPQYFH 312

  Fly   418 IVGNNVSYSGLNNHM--FNSQLRKQSAQFHGQDGFGSGYGSRISIAATQS--------DSRRRRR 472
            :||..:.::.....:  |...|:|...:....:||...:.........|.        |:..|
Human   313 VVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLR-- 375

  Fly   473 RGVGGTSGGHLFPEAISQYAP-------------------------QTYDAVWAIALALRAAEEH 512
               |....|..|..:.:.:.|                         ..|.||::||.||:
Human   376 ---GHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQ----- 432

  Fly   513 WRRNEEQSKLDG---------FDYTRSDMAWEFLQQMGKLHFLGVSG-PVSFSG-PDRVGT---- 562
                :..:.|.|         .|..:.: ||:.|:.:..|:|....| .|:|.. .|.||.
Human   433 ----DIYTCLPGRGLFTNGSCADIKKVE-AWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSII 492

  Fly   563 ---------------TAFYQI-------------------------------------------- 568
                           ..:|.:
Human   493 NWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTFVLSVLQVPFSNCSRDCL 557

  Fly   569 ---QRGLLE------------PVALYYPATDALDFRCPRCRPVKW----HSGQVPIAKRVFKLRV 614
               ::|::|            |...|...|||  ..|.:|....|    |:.  .|||.:..|..
Human   558 AGTRKGIIEGEPTCCFECVECPDGEYSDETDA--SACNKCPDDFWSNENHTS--CIAKEIEFLSW 618

  Fly   615 ATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGL 679
            .....:|....|.|   ||.|....|...:.||....:|.::.:||.:.....:..:::.:..
Human   619 TEPFGIALTLFAVL---GIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFF-- 678

  Fly   680 DHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF-TRTGSVFKDKM----LQDI 739
                :...:|   ..|..|.......|.|....:..||.||..:| .:..:.|..|.    ||
Human   679 ----IGEPQD---WTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQ-- 734

  Fly   740 QLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLE-----ISATDRSVVYQPQVEVCRSQHTQT 799
              .|||.....:..::..:|:.|.|...: .|..||     |:..:.|::.
Human   735 --FLLVFLCTFMQIVICVIWLYTAPPSSY-RNQELEDEIIFITCHEGSLMA-------------- 782

  Fly   800 WLSVLYAYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVS--VYSVVITS---AIVVVLANLIS 858
             |..|..|..||..:..:.|:::|  |:|. .|::::|..|  ::.:|..|   |........:|
Human   783 -LGFLIGYTCLLAAICFFFAFKSR--KLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVS 844

  Fly   859 ERVTLAFITITALILTSTTATLCLLFIPKLHDIW---ARNDIIDPVIHSMGLKMECNT--RRFVV 918
            ....:|       ||.::...|..:|..|::.|.   :||.|.:         :.|:|  ..|.|
Human   845 AVEVIA-------ILAASFGLLACIFFNKIYIILFKPSRNTIEE---------VRCSTAAHAFKV 893

  Fly   919 DDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTV 983
            ..|..|:     ::.|.:|...:|..              :|.:|.|||.|
Human   894 AARATLR-----RSNVSRKRSSSLGG--------------STGSTPSSSIS-------------- 925

  Fly   984 TSGISQTPAASKNRTPSISGILPNLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQPQLEEAC 1048
                    :.|.:..|                 .|:   |..:..|.|:  ::|...|.| :...
Human   926 --------SKSNSEDP-----------------FPQ---PERQKQQQPL--ALTQQEQQQ-QPLT 959

  Fly  1049 LPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGSTASLADQKGLKAAFKSHMGLFTRL 1113
            ||.|.      ..||....|.      :.||...|     .|.||:..:..|.|.
Human   960 LPQQQ------RSQQQPRCKQ------KVIFGSGT-----VTFSLSFDEPQKNAM---------- 997

  Fly  1114 IPSSQTASCNAIYNNPNQDSIPSEASSHPNGNH--LKPIHRGSLTKSGTHLDHLTKDPNFLPIPT 1176
                      |..|:.:|:|:.::.||.....|  |.|:..|.     |.|| ||.....|..|.
Human   998 ----------AHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE-----TDLD-LTVQETGLQGPV 1046

  Fly  1177 ISGGEQ 1182
              ||:|
Human  1047 --GGDQ 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	111/606 (18%)
		ANF_receptor	174..568	CDD:279440	98/491 (20%)
		7tm_3	633..889	CDD:278433	55/271 (20%)
CASR	NP_001171536.2	Ligand-binding 1 (LB1). /evidence=ECO:0000303\|PubMed:17360426	22..188		45/168 (27%)
		PBP1_CaSR	33..530	CDD:380587	105/545 (19%)
		Anion binding. /evidence=ECO:0000269\|PubMed:27434672, ECO:0007744\|PDB:5K5S, ECO:0007744\|PDB:5K5T	66..70		1/3 (33%)
		Ligand-binding 2 (LB2). /evidence=ECO:0000303\|PubMed:17360426	189..324		29/165 (18%)
		Anion binding. /evidence=ECO:0000269\|PubMed:27434672, ECO:0007744\|PDB:5K5S, ECO:0007744\|PDB:5K5T	415..417		0/1 (0%)
		NCD3G	548..601	CDD:369426	9/54 (17%)
		Cysteine-rich (CR). /evidence=ECO:0000303\|PubMed:17360426	552..622		15/73 (21%)
		7tmC_CaSR	621..872	CDD:320409	60/291 (21%)
		TM helix 1	622..646	CDD:320409	7/26 (27%)
		TM helix 2	658..679	CDD:320409	2/26 (8%)
		TM helix 3	688..710	CDD:320409	4/21 (19%)
		TM helix 4	736..752	CDD:320409	3/15 (20%)
		TM helix 5	779..802	CDD:320409	6/37 (16%)
		TM helix 6	811..836	CDD:320409	6/24 (25%)
		TM helix 7	841..866	CDD:320409	6/31 (19%)
		Interaction with RNF19A. /evidence=ECO:0000269\|PubMed:16513638	890..910		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	902..973		23/135 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	996..1016		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1040..1065		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910