DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and GLR2.1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	754	Identity:	150/754 - (19%)
Similarity:	251/754 - (33%)	Gaps:	224/754 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 FHAIYTQPSTRMVMLLGSACSEVTESLA------------KVVPYWNIVQ--------------- 252
            |::.:.:..||:|..:..:.::|..:.|            .::..|..:|
plant    59 FYSSHPETQTRLVTTVVDSKNDVVTAAAAALDLITNKEVKAILGPWTSMQAQFMIEMGQKSQVPI 123

  Fly   253 VSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTE 317
            |::.:|||:|:..|. .||:|....|||...|....|:.|||..|.....::......:..|...
plant   124 VTYSATSPSLASIRS-QYFFRATYDDSSQVHAIKEIIKLFGWREVAPVYVDDTFGEGIMPRLTDV 187

  Fly   318 LEAAN--ISCAATITFAATD--FKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYA 378
            |:..|  |.....|:..|||  ...:||.:....||:.:....:.||.:...:|..:.:....|.
plant   188 LQEINVRIPYRTVISPNATDDEISVELLRMMTLPTRVFVVHLVELLASRFFAKATEIGLMKQGYV 252

  Fly   379 WILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQ 443
            |||..::..               .|::.|...:.|...::|.. :|...:..:.|
plant   253 WILTNTITD---------------VLSIMNETEIETMQGVLGVK-TYVPRSKELEN--------- 292

  Fly   444 FHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRA 508
                  |.|.:..|..|    ||                     ::.|....|||..|:|||:..
plant   293 ------FRSRWTKRFPI----SD---------------------LNVYGLWAYDATTALALAIEE 326

  Fly   509 A--------EEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSF----------- 554
            |        :...:||  .|:|.|...  |....:.||.:.::.|.|::|...|
plant   327 AGTSNLTFVKMDAKRN--VSELQGLGV--SQYGPKLLQTLSRVRFQGLAGDFQFINGELQPSVFE 387

  Fly   555 ------SGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVFKLR 613
                  .|...:|   |:..:.||.:.|.....:.........|.||:.|......:.|.
plant   388 IVNVNGQGGRTIG---FWMKEYGLFKNVDQKPASKTTFSSWQDRLRPIIWPGDTTSVPKG----- 444

  Fly   614 VATIAPLAFYTIATLS---SVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVI 675
                     :.|.|..   .:|:.:...|..|         :|.:...::|.|    ||...::
plant   445 ---------WEIPTNGKRLQIGVPVNNTFQQF---------VKATRDPITNST----IFSGFSI- 486

  Fly   676 LLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAF--GSMFAKTYRVHRIFTRTGSVFKD----- 733
                         |.|..|..|..|.:|..| :.|  |...|..|:|:  ..:..:|..|
plant   487 -------------DYFEAVIQAIPYDISYDF-IPFQDGGYDALVYQVY--LGKYDAVVADTTISS 535

  Fly   734 --KMLQDIQLILLVGGLLLVDALLVTLWVVTDPMER----HLHNLTLEISATDRSVVYQPQVEVC 792
              .|..|..|.....|:.||..       |.|.:.|    .|..|||.:
plant   536 NRSMYVDFSLPYTPSGVGLVVP-------VKDSVRRSSTIFLMPLTLAL---------------- 577

  Fly   793 RSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSV-----YSVVITSAIVVV 852
                   ||..|.::    .::|: :.|...|...|..:......:|.     :|:::.:....|
plant   578 -------WLISLLSF----FIIGL-VVWVLEHRVNPDFDGPGQYQLSTIFWFSFSIMVFAPRERV 630

  Fly   853 LANLISERVTLAFITITALILT-STTATLC-LLFIPKLH 889
            |:  ...||.:.......|:|| |.||:|. ||....||
plant   631 LS--FWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLH 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	84/430 (20%)
		ANF_receptor	174..568	CDD:279440	81/408 (20%)
		7tm_3	633..889	CDD:278433	56/275 (20%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	83/415 (20%)
		ANF_receptor	49..392	CDD:279440	78/393 (20%)
		GluR_Plant	452..794	CDD:270404	59/283 (21%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	54/248 (22%)
		Lig_chan	576..835	CDD:278489	24/122 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910