DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and GLUR2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	1071	Identity:	200/1071 - (18%)
Similarity:	338/1071 - (31%)	Gaps:	361/1071 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 IVLLGLFELSTSRGPRP-----DGLSELG---------AATMAVEHINR-KRLLPGYTLELVTND 202
            |||:|...:|...|.||     ..:..||         |...|.|.:|. ...|.|..|.:.|.|
plant    11 IVLIGDGMISEGAGLRPRYVDVGAIFSLGTLQGEVTNIAMKAAEEDVNSDPSFLGGSKLRITTYD 75

  Fly   203 TQCDPG----VGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALS 263
            .:.: |    :|..:|.       .|..|.::|...|.:...|:.:....::..:||.:..|:||
plant    76 AKRN-GFLTIMGALQFM-------ETDAVAIIGPQTSIMAHVLSHLANELSVPMLSFTALDPSLS 132

  Fly   264 DRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEA--ANISCA 326
             ..:||:|.:|...|.....|....|..:||..|.....:::.....:..|..|||.  ..||..
plant   133 -ALQFPFFVQTAPSDLFLMRAIAEMISYYGWSEVIALYNDDDNSRNGITALGDELEGRRCKISYK 196

  Fly   327 ATITF-----AATDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMG 386
            |.:..     :..:...:|:.::..::|:||.:...:...:|..||.:|.|....|.||
plant   197 AVLPLDVVITSPREIINELVKIQGMESRVIIVNTFPKTGKKIFEEAQKLGMMEKGYVWI------ 255

  Fly   387 APWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFG 451
            |..|........|.......|:|..|.|             |..|..||:.:|
plant   256 ATTWLTSLLDSVNPLPAKTAESLRGVLT-------------LRIHTPNSKKKK------------ 295

  Fly   452 SGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRN 516
                          |...|..:...||.|       ::.|....||.||.||.|::...:. |.|
plant   296 --------------DFVARWNKLSNGTVG-------LNVYGLYAYDTVWIIARAVKRLLDS-RAN 338

  Fly   517 ---EEQSKLDGFDYTRS---------DMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQ 569
               ....||.......|         |...:||..:...:..||:|.:.|. |||
plant   339 ISFSSDPKLTSMKGGGSLNLGALSIFDQGSQFLDYIVNTNMTGVTGQIQFL-PDR---------- 392

  Fly   570 RGLLEPVALYYPATDALDFRCPRCRPVKW---HSGQVPIAKRVFKLRVATIAPLAFYTIATLSSV 631
                   ::..|:.|.::......|.:.:   |||            ::.|.|.:.|
plant   393 -------SMIQPSYDIINVVDDGFRQIGYWSNHSG------------LSIIPPESLY-------- 430

  Fly   632 GIALAIAFLAFNLHFRKLKAIKLSSPKLSNI--------TAVGCIFV-YATVILLG--------- 678
                           :||.....|:..|:|:        |..|.:|. ....:.:|
plant   431 ---------------KKLSNRSSSNQHLNNVTWPGGTSETPRGWVFPNNGRRLRIGVPDRASFKE 480

  Fly   679 ----LDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDI 739
                ||.|.  ..:.....|..|.|.|:|              |.|...|...|...|:....:.
plant   481 FVSRLDGSN--KVQGYAIDVFEAAVKLIS--------------YPVPHEFVLFGDGLKNPNFNEF 529

  Fly   740 QLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVL 804
            ...:.:|   :.||::..:.:||        ..|..:..|      ||.:|
plant   530 VNNVTIG---VFDAVVGDIAIVT--------KRTRIVDFT------QPYIE-------------- 563

  Fly   805 YAYKGLLLVVGVYMAWETRHVKIPALNDSQYI----------GVSVYSVVITSAIVVVLANLISE 859
               .||::|           ..:..|||:.:.          .|:....:|..:::.:|.:.|::
plant   564 ---SGLVVV-----------APVTKLNDTPWAFLRPFTPPMWAVTAAFFLIVGSVIWILEHRIND 614

  Fly   860 R-----------------------------------VTLAFITITALILTSTTATL-CLLFIPKL 888
            .                                   |.|.::.:..:|.:|.||:| .:|.:.:|
plant   615 EFRGPPRKQIVTILWFSFSTMFFSHRENTVSTLGRAVLLIWLFVVLIITSSYTASLTSILTVQQL 679

  Fly   889 HDIWARNDI--IDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLER 951
            :     :.|  :|.:|.|.|                    ||..|...|.:.....:..|.:
plant   680 N-----SPIRGVDTLISSSG--------------------RVGFQVGSYAENYMIDELNIAR--- 716

  Fly   952 LLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILPNLL-LSVLPP 1015
               |.|....:....:.:|..|                |.||..:..|.:...|.... .::...
plant   717 ---SRLVPLGSPKEYAAALQNG----------------TVAAIVDERPYVDLFLSEFCGFAIRGQ 762

  Fly  1016 VIPRASWPSAEYMQIPMRRSVTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINRLRGIF- 1079
            ...|:.|..|.....|:...::.|              ::.|         ::||.:.::...:
plant   763 EFTRSGWGFAFPRDSPLAIDMSTA--------------ILGL---------SETGQLQKIHDKWL 804

  Fly  1080 SRTTSSNKGSTASLADQKGLKAAFKSHMGLF 1110
            ||:..||...:.|..|.:.||  .:|..|||
plant   805 SRSNCSNLNGSVSDEDSEQLK--LRSFWGLF 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	100/470 (21%)
		ANF_receptor	174..568	CDD:279440	93/426 (22%)
		7tm_3	633..889	CDD:278433	50/323 (15%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	99/482 (21%)
		GluR_Plant	466..804	CDD:270404	70/468 (15%)
		Lig_chan	590..840	CDD:395014	52/316 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910