Protein Alignment GABA-B-R3 and GLR2.7

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_180476.3
• Gene: GLR2.7 / 817460
• AraportID: AT2G29120
• Length: 952
• Species: Arabidopsis thaliana
• Alignment Length: 1149
• Identity: 211/1149 - (18%)
• Similarity: 362/1149 - (31%)
• Gaps: 408/1149 - (35%)

  Fly   193 GYTLELVTNDTQ-CDPGVGV---DRF-FHAIYTQPSTRMVM------------------------ 228
            |..|:|.|:.:: |...:.:   |.: :|:.||   ||:.:
plant    42 GVVLDLHTSFSKLCLTSINISLSDFYKYHSDYT---TRLAIHIRDSMEDVVQASSAALDLIKNEQ 103

  Fly   229 ---LLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIR 290
               ::|...|...|.:.::.....:..::|.:|.|.|:.... |||.|....|||...|..|.::
plant   104 VSAIIGPRTSMQAEFMIRLADKSQVPTITFSATCPLLTSINS-PYFVRATLDDSSQVKAIAAIVK 167

  Fly   291 KFGW-GTVTTFSQNE--------------EVHSLAVNNLVTELEAANISCAATITFAATDFKEQL 340
            .||| ..|..:..||              :|.:..||..:...||.:           ....::|
plant   168 SFGWRNVVAIYVDNEFGEGILPLLTDALQDVQAFVVNRCLIPQEAND-----------DQILKEL 221

  Fly   341 LLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLA 405
            ..|....||:.:......|..:...:|..:.|....|.|:|.:                     .
plant   222 YKLMTMQTRVFVVHMPPTLGFRFFQKAREIGMMEEGYVWLLTD---------------------G 265

  Fly   406 VENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRR 470
            |.||:..:...|.:.|.....|:.:|:..|:..|                          :.|.|
plant   266 VMNLLKSNERGSSLENMQGVLGVRSHIPKSKKLK--------------------------NFRLR 304

  Fly   471 RRRGVGGTSGGHLFP-----EAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRS 530
            ..:         :||     |.::.:|.:.||::.|:|:|:           |::.:....|...
plant   305 WEK---------MFPKKGNDEEMNIFALRAYDSITALAMAV-----------EKTNIKSLRYDHP 349

  Fly   531 DMAWEFLQQMGKLHFLGVS--GPVSFSGPDRV---GTTAFYQIQRGLLEP--------------- 575
            ..:......:|.   ||||  ||........|   |....:::..|.||.
plant   350 IASGNNKTNLGT---LGVSRYGPSLLKALSNVRFNGLAGEFELINGQLESSVFDVINIIGSEERI 411

  Fly   576 VALYYPATDALDFRC--------PRCRPVKW--HSGQVPIAKRVFKLRVATIAPLAFYTIATLSS 630
            :.|:.|:...::.:.        .|..||.|  .|..||...::         |    |...:..
plant   412 IGLWRPSNGIVNAKSKNTTSVLGERLGPVIWPGKSKDVPKGWQI---------P----TNGKMLR 463

  Fly   631 VGIALAIAFLAFNLHFRKLKAIKLSSPKLSN-ITAVG-CIFVYATVILLGLDHSTLPSAEDSFAT 693
            |||.:...||.|         :......:|| :|..| ||.::..| |..|.:|.:|.
plant   464 VGIPVKKGFLEF---------VDAKIDPISNAMTPTGYCIEIFEAV-LKKLPYSVIPK------- 511

  Fly   694 VCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTL 758
                  |:........:..|..:.|        ||:.  |.::.|:.::
plant   512 ------YIAFLSPDENYDEMVYQVY--------TGAY--DAVVGDVTIV---------------- 544

  Fly   759 WVVTDPMERHLH-NLTLEISATDRSVVYQPQVEVCRSQHTQTWLSV------LYAYKGLLLVVGV 816
                  ..|.|: :.||..:.:..|::      |....:..||:.:      |:.......|...
plant   545 ------ANRSLYVDFTLPYTESGVSMM------VPLKDNKNTWVFLRPWSLDLWVTTACFFVFIG 597

  Fly   817 YMAWETRHVKIPALNDS------QYIGVSVYSVVITSAIV---VVLANLISERVTLAFITITALI 872
            ::.|...|    .:|..      ..||.|.:....|....   .|::|| :..|.|.:..:..::
plant   598 FIVWILEH----RVNTDFRGPPHHQIGTSFWFAFSTMNFAHREKVVSNL-ARFVVLVWCFVVLVL 657

  Fly   873 LTSTTATLCLLFIPKL--------HDI--------WARNDIIDPVIHSMGLKMECNTRRFVVDDR 921
            :.|.||.|...|..||        .|:        :.|...:..::.|.|.            |.
plant   658 IQSYTANLTSFFTVKLLQPTVTNWKDLIKFNKNIGYQRGTFVRELLKSQGF------------DE 710

  Fly   922 RELQ---YRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSSSTSLLTGG-GHLKPE-- 980
            .:|:   ..||.........|.|...|:..::.:|..   .:|..|....|..|.| |.:.|:
plant   711 SQLKPFGSAVECDELFSNGTITASFDEVAYIKVILSQ---NSSKYTMVEPSFKTAGFGFVFPKKS 772

  Fly   981 ----------LTVTSGISQTPAASK-----NRTPSISGILPNLLLSVLPPVIPRASW------PS 1024
                      |.||.|.......:|     |..|.::..|.:..||:      .:.|      ..
plant   773 PLTDDVSRAILNVTQGEEMQHIENKWFKKPNNCPDLNTSLSSNHLSL------SSFWGLFLIAGI 831

  Fly  1025 AEYMQIPMRRSVTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGS 1089
            |.::.:     :.|.:               |....|:..             :|..:.:|.:|.
plant   832 ASFLAL-----LIFVA---------------NFLYEHKHT-------------LFDDSENSFRGK 863

  Fly  1090 TASLA---DQKGLKAAFKSHMGLFTRLIPSSQTASCNAIYNNPNQDSIPSEASSHPNGNHLKPIH 1151
            ...|.   |:|.:    ||||  |..          ||::|          .||        ||.
plant   864 LKFLVRNFDEKDI----KSHM--FKE----------NAVHN----------VSS--------PIT 894

  Fly  1152 RGS---LTKSGTHLDHLTKDPNFLP---IPTISGGE----QGDQ 1185
            :||   ||...|.|....:....|.   :.:||.||    |.:|
plant   895 QGSSSPLTDQSTPLPRSPEQYRELELRRVSSISSGELFTTQSEQ 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	88/488 (18%)
		7tmC_GABA-B-like	621..892	CDD:320175	55/304 (18%)
		TM helix 1	621..645	CDD:320175	7/23 (30%)
		TM helix 2	657..678	CDD:320175	8/22 (36%)
		TM helix 3	696..720	CDD:320175	3/23 (13%)
		TM helix 4	741..761	CDD:320175	0/19 (0%)
		TM helix 5	797..823	CDD:320175	5/31 (16%)
		TM helix 6	832..855	CDD:320175	5/31 (16%)
		TM helix 7	862..887	CDD:320175	6/24 (25%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor_plant	40..423	CDD:380645	84/465 (18%)
		GluR_Plant	460..799	CDD:270404	77/419 (18%)
		Lig_chan	582..832	CDD:459656	51/275 (19%)