Protein Alignment GABA-B-R3 and GLR2.2

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_180048.1
• Gene: GLR2.2 / 817008
• AraportID: AT2G24720
• Length: 920
• Species: Arabidopsis thaliana
• Alignment Length: 794
• Identity: 157/794 - (19%)
• Similarity: 262/794 - (32%)
• Gaps: 276/794 - (34%)

  Fly   215 FHAIYTQPSTRMVMLLGSACSEV------------TESLAKVVPYWNIVQ--------------- 252
            |::...|..||:|:.:|.:.::|            .:.:..::..|..:|
plant    59 FYSSRPQFQTRLVVNVGDSKNDVVGAATAAIDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPV 123

  Fly   253 VSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTV------TTFSQNEEVHSLAV 311
            ||:.:|||:|:..|. |||:|....|||...|..|.|:.|||..|      .||.:.      .:
plant   124 VSYSATSPSLTSLRS-PYFFRATYEDSSQVHAIKAIIKLFGWREVVPVYIDNTFGEG------IM 181

  Fly   312 NNLVTELEAAN--ISCAATITFAAT--DFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRM 372
            ..|...|:..|  |...:.|...||  |...:||.:....||:.|...|..||..:..:|..|.:
plant   182 PRLTDSLQDINVRIPYRSVIPLNATDQDISVELLKMMNMPTRVFIVHMSSSLASTVFIKAKELGL 246

  Fly   373 FGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQL 437
            ....|.|||...:     .|...:.:...:: |:|.::                |:..::..|
plant   247 MKPGYVWILTNGV-----MDGLRSINETGIE-AMEGVL----------------GIKTYIPKS-- 287

  Fly   438 RKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPE-AISQYAPQTYDAVWA 501
             |....|.                     ||.:||           ||: .::.|....|||..|
plant   288 -KDLETFR---------------------SRWKRR-----------FPQMELNVYGLWAYDATTA 319

  Fly   502 IALALRAAE------EHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSF-SGPDR 559
            :|:|:..|.      .:....:..|:|||...  |....:.||.:..:.|.|::|...| ||
plant   320 LAMAIEDAGINNMTFSNVDTGKNVSELDGLGL--SQFGPKLLQTVSTVQFKGLAGDFHFVSG--- 379

  Fly   560 VGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYT 624
                   |:|..:.|.|.:......::.|         |..|...:.|...:.|          :
plant   380 -------QLQPSVFEIVNMIGTGERSIGF---------WTEGNGLVKKLDQEPR----------S 418

  Fly   625 IATLSS-------------------------------VGIALAIAFLAFNLHFRKLKAIKLSSPK 658
            |.|||:                               :|:...|.|         ...:|::...
plant   419 IGTLSTWPDHLKHIIWPGEAVSVPKGWEIPTNGKKLRIGVPKRIGF---------TDLVKVTRDP 474

  Fly   659 LSNITAVG--CIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAK----- 716
            ::|.|.|.  ||                    |.|..|..|..|.:|..|     ..|.|
plant   475 ITNSTVVKGFCI--------------------DFFEAVIQAMPYDVSYEF-----FPFEKPNGEP 514

  Fly   717 ----TYRVHRIFT-RTGSVFKDKML-------QDIQLILLVGGLLLVDALLVTLWVVTDPMER-- 767
                ...||:::. :..:|..|..:       .|..|..:..|:    .|:|.|   .|.::|
plant   515 AGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGV----GLIVPL---KDEVKRDK 572

  Fly   768 --HLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRH-VKIPA 829
              .|..|::|:                       ||:.|..:    .:||: ..|...| |....
plant   573 FSFLKPLSIEL-----------------------WLTTLVFF----FLVGI-SVWTLEHRVNSDF 609

  Fly   830 LNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFIT--ITALILT-STTATLCLLFIPKLHDI 891
            ...:.|...:::....::.:......::|.......:|  ...|:|| |.||:|..|.
plant   610 RGPANYQASTIFWFAFSTMVFAPRERVLSFGARSLVVTWYFVLLVLTQSYTASLASLL------- 667

  Fly   892 WARNDIIDPVIHSM 905
              .:..::|.|.||
plant   668 --TSQQLNPTITSM 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	94/429 (22%)
		7tmC_GABA-B-like	621..892	CDD:320175	56/328 (17%)
		TM helix 1	621..645	CDD:320175	7/54 (13%)
		TM helix 2	657..678	CDD:320175	5/22 (23%)
		TM helix 3	696..720	CDD:320175	6/32 (19%)
		TM helix 4	741..761	CDD:320175	5/19 (26%)
		TM helix 5	797..823	CDD:320175	6/25 (24%)
		TM helix 6	832..855	CDD:320175	1/22 (5%)
		TM helix 7	862..887	CDD:320175	9/27 (33%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor_plant	33..412	CDD:380645	95/437 (22%)
		GluR_Plant	452..801	CDD:270404	56/306 (18%)