DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and Grm7

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:XP_038964350.1 Gene:Grm7 / 81672 RGDID:619857 Length:922 Species:Rattus norvegicus


Alignment Length:1027 Identity:203/1027 - (19%)
Similarity:374/1027 - (36%) Gaps:283/1027 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 RNHGKIVLLGLFELSTSRGP---------RPDGLSELGAATMAVEHINR-KRLLPGYTL------ 196
            |..|.:.|.|||.:. ::||         |.:|:..|.|...|::.||. ..|||..||      
  Rat    44 RIEGDVTLGGLFPVH-AKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILD 107

  Fly   197 --------------------ELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESL 241
                                :..|:|.:|..|.      ..::.:|. ::|.::|::.|.|:..:
  Rat   108 TCSRDTYALEQSLTFVQALIQKDTSDVRCTNGE------PPVFVKPE-KVVGVIGASGSSVSIMV 165

  Fly   242 AKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEV 306
            |.::..:.|.|:|:.||:|.|||.|.:.:|.|.|.|||....|.:..::..||..|:|.:.....
  Rat   166 ANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSY 230

  Fly   307 HSLAVNNLVTEL--EAANISCAATITF------AATDFKEQLLLLRET-DTRIIIGSFSQELAPQ 362
            ....|.:. |::  ||..:..|.::..      ...||...:..|.:| ::|.::...:.|...|
  Rat   231 GEKGVESF-TQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQ 294

  Fly   363 ILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSG 427
            ||..|.|....| .:.|:..:|.|:...|       .|:.:...|..|.:....:.|      .|
  Rat   295 ILAAAKRADQVG-HFLWVGSDSWGSKINP-------LHQHEDIAEGAITIQPKRATV------EG 345

  Fly   428 LNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRG---VGGTSGGHLFPEAIS 489
            .:.:..:..|..........:.:...:..:::|:.::.:...|:..|   :|..|  :...|...
  Rat   346 FDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDS--NYEQEGKV 408

  Fly   490 QYAPQTYDAVWAIALALRAAEEHWRRN---------EEQSKLDGFDYTRSDMAWEFLQQMGKLHF 545
            |:   ..|||:|:|.||    .|..::         .|..:..|         .:.|:.:..::|
  Rat   409 QF---VIDAVYAMAHAL----HHMNKDLCADYRGVCPEMEQAGG---------KKLLKYIRHVNF 457

  Fly   546 LGVSG-PVSFS-GPDRVGTTAFYQIQ-----------------------------RGL------- 572
            .|.:| ||.|: ..|..|....:|.|                             :|:       
  Rat   458 NGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSV 522

  Fly   573 ----------------------LEPVALYYPATDALDFRCPRC----RPVKWHSG--QVPIAKRV 609
                                  .||...|....|  :..|..|    ||.:..:|  .:||.|..
  Rat   523 CTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFD--EMTCQHCPYDQRPNENRTGCQNIPIIKLE 585

  Fly   610 FKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATV 674
            :.      :|.|...: .|:.:||...|..:|..:.:.....::.|..:||.:...|....|...
  Rat   586 WH------SPWAVIPV-FLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIIT 643

  Fly   675 ILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQD 738
            .|:        .|:...| ||:.|...|..|..:::.::..||.|::|||.: ..||...:::..
  Rat   644 FLM--------IAKPDVA-VCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISP 699

  Fly   739 IQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVE--VCRSQHTQTWL 801
            ...:.:...|:.|..|.|.:|...||     .|:.::.   |......|:..  |.:...|...:
  Rat   700 TSQLAITSSLISVQLLGVFIWFGVDP-----PNIIIDY---DEHKTMNPEQARGVLKCDITDLQI 756

  Fly   802 SVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVLANLI--SERVTL 863
            .....|..||:|.....|.:||.|. ...|:::.||.::|:. ::..|.:.:.....  :|::.:
  Rat   757 ICSLGYSILLMVTCTVYAIKTRGVP-ENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820

  Fly   864 AFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRV 928
            ...|:|..:..|.:..|.:|::||::.|         :.|.                    :..|
  Rat   821 QTTTLTISMNLSASVALGMLYMPKVYII---------IFHP--------------------ELNV 856

  Fly   929 EVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAA 993
            :.:.|.:|..:.|                                       .|::|.:|..|:.
  Rat   857 QKRKRSFKAVVTA---------------------------------------ATMSSRLSHKPSD 882

  Fly   994 SKN---RTPSISGILPNLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQP 1042
            ..|   :|.....:.||   :.:|||  |.|          :::|||:.:.|
  Rat   883 RPNGEAKTELCENVDPN---NCIPPV--RKS----------VQKSVTWYTIP 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 112/564 (20%)
7tmC_GABA-B-like 621..892 CDD:320175 60/276 (22%)
TM helix 1 621..645 CDD:320175 6/23 (26%)
TM helix 2 657..678 CDD:320175 5/20 (25%)
TM helix 3 696..720 CDD:320175 5/23 (22%)
TM helix 4 741..761 CDD:320175 5/19 (26%)
TM helix 5 797..823 CDD:320175 6/25 (24%)
TM helix 6 832..855 CDD:320175 4/23 (17%)
TM helix 7 862..887 CDD:320175 5/24 (21%)
Grm7XP_038964350.1 PBP1_mGluR_groupIII 43..511 CDD:380599 106/507 (21%)
NCD3G 519..569 CDD:462210 6/51 (12%)
7tmC_mGluR7 589..895 CDD:320567 73/392 (19%)
TM helix 1 589..614 CDD:320567 7/25 (28%)
TM helix 2 626..647 CDD:320567 5/28 (18%)
TM helix 3 656..680 CDD:320567 5/23 (22%)
TM helix 4 702..722 CDD:320567 5/19 (26%)
TM helix 5 752..778 CDD:320567 6/25 (24%)
TM helix 6 786..809 CDD:320567 4/22 (18%)
TM helix 7 819..844 CDD:320567 5/24 (21%)

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