DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Gabbr1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_006255941.1	Gene:	Gabbr1 / 81657	RGDID:	621537	Length:	991	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	262/906 - (28%)
Similarity:	420/906 - (46%)	Gaps:	128/906 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 RRQQRLNSHSNLPGSTNASHAHHLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLG-LF 159
            |.:.|.:...:|.||:.:..:....:.|  :.:.:||:...||||            .|.:| ||
  Rat   125 RVEFRCDPDFHLVGSSRSVCSQGQWSTP--KPHCQVNRTPHSERR------------AVYIGALF 175

  Fly   160 ELSTSRGPRPDGLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPS 223
            .:|   |..|.|.:...|..||:|.:|.:| :||.|.|:|:.:|::||||......:..:|..|
  Rat   176 PMS---GGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDP- 236

  Fly   224 TRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAF 288
            .:::::.|  ||.|:..:|:....||::.:|:||:|||||:|:.||.|:||....:.|||.|:..
  Rat   237 IKIILMPG--CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKL 299

  Fly   289 IRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLL---LLRETDTRI 350
            ..|:||..:.|..|..||.:..:::|...::.|.|.    |||..:.|.:..:   .|:..|.||
  Rat   300 FEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIE----ITFRQSFFSDPAVPVKNLKRQDARI 360

  Fly   351 IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWP--DQRTACSNHELQLAVENLIVVS 413
            |:|.|.:..|.::.||.|:.|:||..|.|.|.......|:.  |....|:..|:..|||..|...
  Rat   361 IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEGHITTE 425

  Fly   414 THNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGT 478
            .......|..|.|.:.:..|..:|.|:                           .:|.....||
  Rat   426 IVMLNPANTRSISNMTSQEFVEKLTKR---------------------------LKRHPEETGG- 462

  Fly   479 SGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKL 543
                      .|.||..|||:||:||||........|:  ..:|:.|:|....:..:..:.|...
  Rat   463 ----------FQEAPLAYDAIWALALALNKTSGGGGRS--GVRLEDFNYNNQTITDQIYRAMNSS 515

  Fly   544 HFLGVSGPVSF--SGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIA 606
            .|.||||.|.|  || .|:..|...|:|.|..:.:..|....|.|.:    .:..||..|..|..
  Rat   516 SFEGVSGHVVFDASG-SRMAWTLIEQLQGGSYKKIGYYDSTKDDLSW----SKTDKWIGGSPPAD 575

  Fly   607 KRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVY 671
            :.:.......::...|.:::.|||:||.||:..|:||::...::.|:.|.|.|:|:|||||....
  Rat   576 QTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLAL 640

  Fly   672 ATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKD--- 733
            |.|..||||...:  ....|..||.||::||..||||.:||||.|.:.||.:||:     |:
  Rat   641 AAVFPLGLDGYHI--GRSQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTK-----KEEKK 698

  Fly   734 ---KMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQ 795
               |.|:..:|...||.|:.:|.|.:.:|.:.||:.|.:.....|....|..|...||:|.|.|:
  Rat   699 EWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSK 763

  Fly   796 HTQTWL-------------------------------SVLYAYKGLLLVVGVYMAWETRHVKIPA 829
            ...|||                               |:.|.||||||::|:::|:||:.|....
  Rat   764 KMNTWLGELWSFAVSSDVQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEK 828

  Fly   830 LNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWAR 894
            :||.:.:|:::|:|.:...|...:..::|.:...||...:..|:.|:..||.:||:||:..:..|
  Rat   829 INDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITR 893

  Fly   895 NDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLES 955
            .:.......:|......|      ::..|....:|.:||..:|.|...:..:.:|...|:|
  Rat   894 GEWQSETQDTMKTGSSTN------NNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQS 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	132/441 (30%)
		ANF_receptor	174..568	CDD:279440	119/401 (30%)
		7tm_3	633..889	CDD:278433	96/292 (33%)
Gabbr1	XP_006255941.1	Sushi	106..156	CDD:278512	6/32 (19%)
		PBP1_GABAb_receptor	170..562	CDD:107361	132/446 (30%)
		ANF_receptor	186..542	CDD:279440	120/403 (30%)
		7tm_3	602..887	CDD:278433	95/291 (33%)
		Ax_dynein_light	<915..957	CDD:287215	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820