Protein Alignment GABA-B-R3 and TAS1R2

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_689418.2
• Gene: TAS1R2 / 80834
• HGNCID: 14905
• Length: 839
• Species: Homo sapiens
• Alignment Length: 943
• Identity: 180/943 - (19%)
• Similarity: 303/943 - (32%)
• Gaps: 341/943 - (36%)

  Fly   143 PAEMQRNH--GKIVLLGLFEL-STSRG----------------PRPDGLSELGAATMAVEHINR- 187
            |||....:  |..:|.|||.| :..:|                .:..|.:.:.|...|||.||.
Human    21 PAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINND 85

  Fly   188 KRLLPGYTL--ELV-----TNDTQCDPGVGVDRFFHA----------IYTQPSTRMVMLLGSACS 235
            ..||||..|  |:|     :|:.|  |.:    :|.|          .|:...:|:|.::|...|
Human    86 SSLLPGVLLGYEIVDVCYISNNVQ--PVL----YFLAHEDNLLPIQEDYSNYISRVVAVIGPDNS 144

  Fly   236 EVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWG----- 295
            |...::|..:..:.:.|:::.:.|..|.|:..||...||......|..|.:..:..|.|.
Human   145 ESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVL 209

  Fly   296 -----------------------------TVTTFSQNEEVHSLAVNNLVTELEAANISCAATITF 331
                                         |:.|...|:.:.|.....|||.::....|.|..:..
Human   210 VSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVV 274

  Fly   332 AATD------FKEQLLLLRETDTRII-IGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAP- 388
            .:.|      |.|   :||:..|..: |.|.|..:.| :|.....||..|. :..|..:|:..|
Human   275 FSPDLTLYHFFNE---VLRQNFTGAVWIASESWAIDP-VLHNLTELRHLGT-FLGITIQSVPIPG 334

  Fly   389 ------WWPD------QRTACS---NHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLR 438
                  |.|.      .||:.|   |.|....:...:..:|...:.|..|.||
Human   335 FSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYS------------ 387

  Fly   439 KQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIA 503
                                                                    .|.||:|:|
Human   388 --------------------------------------------------------VYSAVYAVA 396

  Fly   504 LALRAAEEHWRRNEEQSKLDGFDYT----RSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRV---- 560
            .||.:             |.|.|.:    |....|:.|:::.|::|..:...:.|.....|
Human   397 HALHS-------------LLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHL 448

  Fly   561 ---------------GTTAFYQIQRGL-----------------------------LEPVALYYP 581
                           ...::|.:||.|                             .:||.::..
Human   449 EIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVC 513

  Fly   582 ATDALD-------------FRCPRCRPVKW-HSGQVPIAKR--VF-------KLRVATIAPLAFY 623
            ..:.:|             :.|..|...:| :..:....||  ||       .:.||.:|.|.|.
Human   514 CFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFL 578

  Fly   624 -TIATL------------SSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVI 675
             |:|.|            .|.|..:....|...|....:..:.:..||:|.......:|.....|
Human   579 STLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTI 643

  Fly   676 LLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQDI 739
            .:..      .|..||..||         .|.:|  |.|.:.|   ..:.| .|.......:..:
Human   644 CISC------IAVRSFQIVC---------AFKMA--SRFPRAY---SYWVRYQGPYVSMAFITVL 688

  Fly   740 QLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEV--CRSQHTQTWLS 802
            :::::|.|:|...                       :|.|.|:....|::.:  |...:..   |
Human   689 KMVIVVIGMLATG-----------------------LSPTTRTDPDDPKITIVSCNPNYRN---S 727

  Fly   803 VLY--AYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVYSVVITSAIVVVLANLISE----R 860
            :|:  :...||.|||...|:..:  ::|. .|::::|.:|: :...||:  |.|...:|.    .
Human   728 LLFNTSLDLLLSVVGFSFAYMGK--ELPTNYNEAKFITLSM-TFYFTSS--VSLCTFMSAYSGVL 787

  Fly   861 VTLAFITITALILTSTT----ATLC--LLFIPK 887
            ||:..:.:|.|.|.:.:    ...|  :||.|:
Human   788 VTIVDLLVTVLNLLAISLGYFGPKCYMILFYPE 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	105/589 (18%)
		ANF_receptor	174..568	CDD:279440	93/491 (19%)
		7tm_3	633..889	CDD:278433	53/271 (20%)
TAS1R2	NP_689418.2	PBP1_Taste_receptor	27..484	CDD:107358	104/548 (19%)
		ANF_receptor	70..454	CDD:279440	92/475 (19%)
		NCD3G	493..543	CDD:284890	5/49 (10%)
		7tm_3	577..814	CDD:278433	56/287 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910