DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfck2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_001334567.2	Gene:	olfck2 / 794572	ZFINID:	ZDB-GENE-050419-85	Length:	856	Species:	Danio rerio

Alignment Length:	947	Identity:	195/947 - (20%)
Similarity:	332/947 - (35%)	Gaps:	296/947 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GKIVLLGLFEL---------STSRGPRPDGLS------EL---GAATMAVEHINRKR-LLPG--- 193
            |..::.|.|.:         :.:|.|:|...|      ||   .|...|::.||... ||||
Zfish    44 GDFIVGGAFTIHYYVRTEKYTYTRRPQPLECSGSMDFRELRFARALQFAIQEINNSSDLLPGIFL 108

  Fly   194 ----------------YTLELVT------NDT-QCDPGVGVDRFFHAIYTQPSTRMVMLLGSACS 235
                            ..|:|..      ||| .|               ..|..::.|:|.:.|
Zfish   109 GYHIYDSCGSVPMAIKVALQLANGLDPKYNDTDSC---------------AKSAAVLALVGDSAS 158

  Fly   236 EVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIA-FIRKFGWGTVTT 299
            ....|::::...:.|.|||..:|...|||:|:.|.|:||: |...|..|.:| .:::|||..:..
Zfish   159 TPAISISRIFGPFEIPQVSHYATCACLSDKRQHPTFFRTI-PSDHHQAAALARMVKRFGWTWIGA 222

  Fly   300 FSQNEEVHSLAVNNLVTELEAA-------NISCAATITFAATDFKEQLLLLRETDTRIIIGSFS- 356
            ...:.:..:   |.:.:.|:||       ..|.|...|:..:..|....::|.:..|:|:...:
Zfish   223 VRSDSDYGN---NGMASFLKAAEKEGICVEYSEAYYRTYPLSKLKRVADVIRRSTARVIVAFVAA 284

  Fly   357 -------QELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVST 414
                   :||:.:.|          ....||..|:    |..|.:....|    |::..:.|...
Zfish   285 GDMRFLLEELSKEPL----------PPMQWIGSEA----WVSDPQMLRFN----LSIGTMGVAVP 331

  Fly   415 HNSIVGNNVSYSGLNNH--------------MFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQS 465
            .:.|.|.......|:.:              .|:..|::|:....|..            |...:
Zfish   332 RSLIPGFRKFLLDLSPYKVLKFPLLTEFWESSFSCSLQQQTDPSTGMP------------ACDGT 384

  Fly   466 DSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAA---EEHWRRNEEQSKLDGFD- 526
            :...|.:.....||.        .:.:...|.|.:|||.||...   |....:|.:......||
Zfish   385 EDLGRLKNPYTDTSQ--------LRVSNMVYKATYAIAHALHGIVCNETQCSKNIKVKPRQVFDQ 441

  Fly   527 -----YTRSDMAWEF----------------LQQMGKLHFLGV-----SGP-----------VSF 554
                 :::::.:..|                ||..|.:.|:.|     |.|           :.:
Zfish   442 LKQVNFSKNNYSVSFDANGDPVAVYELVNWQLQGDGSIDFVTVGKYDASQPEGQEFSLNKAIIWY 506

  Fly   555 SGPDRVGTTAFYQ---------IQRGLLEPVALY--YPA--------TDALDFRCPRCRPVKWHS 600
            .|.::|..:...:         :::|  .||..|  .|.        ||:.|  |.:|.|..|.|
Zfish   507 DGSEKVPVSVCSENCPPGTRKAVKKG--RPVCCYDCIPCGEGEISNKTDSPD--CDKCPPDYWPS 567

  Fly   601 GQ----VPIAKRVFKLRVATIAPLAFYT--------IATLSSVGIALAIAFLAFNLHFRKLKA-- 651
            .:    :|             .|:.|.:        :|.||..|..||   |:..|.|.|.:|
Zfish   568 TEKDKCLP-------------KPVEFLSWDEILGIILAVLSVSGSLLA---LSMALVFYKNRASP 616

  Fly   652 -IKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFA 715
             ::.::.:||.:    .:|......|..|.....|:...     |..|.......|.|....:..
Zfish   617 IVRANNSELSFL----LLFSLTLCFLCSLTFIGQPTEWS-----CMLRHTAFGITFVLCISCVLG 672

  Fly   716 KTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------MERHLHNL 772
            ||..|...|..|  ||... |.....|..|.|.|..||..::..||:...|      |:.:...:
Zfish   673 KTIVVLMAFKATLPGSNVM-KWFGPPQQRLSVFGFTLVQIIICVLWLTISPPFPYKNMQHYKDKI 736

  Fly   773 TLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYI 836
            .||.|.               ......|  |:..|.|||..:...:|:..|  |:| ..|::::|
Zfish   737 ILECSL---------------GSAVGFW--VVLGYIGLLASLCFVLAFLAR--KLPDNFNEAKFI 782

  Fly   837 GVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDII 898
               .:|::|.||: :..:...:|.  :.|:| :.|.|::.:|.:..|| :|.||...|..|
Zfish   783 ---TFSMLIFSAVWITFIPAYVSSPGKFTVA-VEIFAILASSFSLILC-IFAPKFFIILFR---- 838

  Fly   899 DPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVY 935
                      .|.||::.::.         :||::.|
Zfish   839 ----------PEENTKKHLMG---------KVQSKSY 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	109/567 (19%)
		ANF_receptor	174..568	CDD:279440	95/503 (19%)
		7tm_3	633..889	CDD:278433	65/270 (24%)
olfck2	XP_001334567.2	Periplasmic_Binding_Protein_Type_1	44..505	CDD:299141	100/517 (19%)
		ANF_receptor	88..472	CDD:279440	84/440 (19%)
		NCD3G	514..565	CDD:284890	11/54 (20%)
		7tm_3	600..834	CDD:278433	65/270 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910