Protein Alignment GABA-B-R3 and olfcu1

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001076368.1
• Gene: olfcu1 / 794431
• ZFINID: ZDB-GENE-050419-175
• Length: 868
• Species: Danio rerio
• Alignment Length: 905
• Identity: 195/905 - (21%)
• Similarity: 324/905 - (35%)
• Gaps: 250/905 - (27%)

  Fly   151 GKIVLLGLFELSTSRGPRPD-GLSEL---------------GAATM--AVEHIN-RKRLLPG--- 193
            |.||:.|||.:. :..|..| ..|:|               ...||  |:|.|| ...||||
Zfish    44 GDIVIGGLFPMH-NIAPETDYNFSDLPHYQDCSRFDFRAFRWVQTMVFAIEEINSNSSLLPGVAL 107

  Fly   194 -------------------YTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTE 239
                               :.|......||.| .||.   .:.:.|.|   :..::|.|.|..|.
Zfish   108 GYRILDSCDHVHTSLRSALFLLNGTFGQTQTD-AVGT---ANCLSTAP---VPAVIGLASSSPTR 165

  Fly   240 SLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNE 304
            ::|:.:..:.|..:|:.:|...|:|::|:|.|.|||..|.......:..:..|||..|.|...::
Zfish   166 AVAQTLGPFGIPLISYFATCTCLTDKKEYPSFLRTVPSDRFQVQGLVQLVSHFGWRWVGTVGTDD 230

  Fly   305 EVHSLAVNNLVTELEAANISCAA---TITFAATDFKEQLLL--LRETDTRIIIGSFSQELAPQIL 364
            :.....:.....:||... ||.|   ||..:.:..:.:.:|  |..:..::||...::....::|
Zfish   231 DYSHYGIQAFTEQLERLG-SCIAFHQTIPKSPSQAQIRSILNSLESSTAQVIIAFATEGELLELL 294

  Fly   365 CEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYS--- 426
            .|..|..:  ....|:..|:     |             :..:.|.:...|..::| .|.:|
Zfish   295 VEVARRNL--TRLQWVASEA-----W-------------VTAKLLTIPELHPVLIG-TVGFSFRG 338

  Fly   427 ----GLNNHMF--NSQLRKQSA--QFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHL 483
                ||...:|  ....|.:||  ....::.||...|...|     :||      .:...:|...
Zfish   339 TAIPGLAEFLFRVRPSSRPESAFTNMFWEELFGCRLGYEDS-----NDS------VLPLCTGSEN 392

  Fly   484 FPEAISQYAP--------QTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDY---TRSDMA-WEF 536
            ..|..|.|..        ..|.||:|||.||.      :..:..||..|.|:   |.|..: .:.
Zfish   393 LLETESSYTDVSRVRISYNVYKAVYAIAHALH------QLLQCGSKEQGSDHSCNTESKFSPLQL 451

  Fly   537 LQQMGKLHFL--------------------------GVSGPVSFSGPDRVGTTAFY--------- 566
            |:.:.|:||.                          ...|.::|   ..|||   |
Zfish   452 LRYLKKVHFTNQFNEKVYFDTNGEPVPLYDIINWQKNARGTINF---QLVGT---YDGSAPHGQQ 510

  Fly   567 -QIQRGLLE--------PVALYYP--------AT---------DALD------------FRCPRC 593
             :|:.||:.        ||:|..|        ||         |.|.            ..|.:|
Zfish   511 LKIEEGLIRWTGGQTKVPVSLCSPPCPPGTRQATRPGQPVCCFDCLPCAEGEISNISGATECLKC 575

  Fly   594 RPVKWHSGQVPIAKRVFKLRVATIAP----LAFYTI-----ATLSSVGIALAIAFLAFNLHFRKL 649
            ....|.:          |.||:.:|.    |:::.:     .:||..|:|:|...:.....||..
Zfish   576 PEYYWPN----------KERVSCVAGIEEFLSYHDVMGIILISLSLFGVAVATVVMVIFFIFRST 630

  Fly   650 KAIKLSSPKLSNITAVGCIFVY-ATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSM 713
            ..:|.::.::|.:..:.....: .:::.:|     .||     ...|.||.......|.|....:
Zfish   631 PIVKANNSEMSFLLLLSLKLCFLCSLVFVG-----RPS-----PLTCRARQAAFGISFVLCISCI 685

  Fly   714 FAKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEI 776
            ..||..|...|..|  ||: ..|:....|..:.:........:|...|:...|...:.:.
Zfish   686 LVKTIVVLLAFRSTVPGSI-SLKVFGPPQQRVFIFCCTTGQVILCACWLALAPPYPYKNT----- 744

  Fly   777 SATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSV 840
            |..|..::.:     |:......:..|| .|.|||..:...:|:..|  |:| ..|:::.|   .
Zfish   745 SYQDGRIILE-----CKDILPLGFYLVL-GYIGLLSCMCFVLAFLGR--KLPDTFNEAKLI---T 798

  Fly   841 YSVVITSAI---VVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDI 897
            :|::|..|:   .:...|....:.|:| :.|.| ||.||...|..:||||.:.|..|.|:
Zfish   799 FSMLIFCAVWISFIPAYNSSPGKYTVA-VEIFA-ILASTFGLLFSIFIPKCYVILLRPDL 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	123/585 (21%)
		7tmC_GABA-B-like	621..892	CDD:320175	61/282 (22%)
		TM helix 1	621..645	CDD:320175	5/28 (18%)
		TM helix 2	657..678	CDD:320175	1/21 (5%)
		TM helix 3	696..720	CDD:320175	6/23 (26%)
		TM helix 4	741..761	CDD:320175	2/19 (11%)
		TM helix 5	797..823	CDD:320175	7/25 (28%)
		TM helix 6	832..855	CDD:320175	4/25 (16%)
		TM helix 7	862..887	CDD:320175	11/24 (46%)
olfcu1	NP_001076368.1	PBP1_CaSR	47..520	CDD:380587	113/525 (22%)
		NCD3G	528..581	CDD:462210	10/52 (19%)
		7tmC_V2R_pheromone	602..852	CDD:320410	62/278 (22%)
		TM helix 1	602..626	CDD:320410	5/23 (22%)
		TM helix 2	638..659	CDD:320410	1/20 (5%)
		TM helix 3	668..692	CDD:320410	6/23 (26%)
		TM helix 4	716..732	CDD:320410	1/15 (7%)
		TM helix 5	759..785	CDD:320410	7/26 (27%)
		TM helix 6	793..816	CDD:320410	4/25 (16%)
		TM helix 7	821..846	CDD:320410	11/26 (42%)