DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfcn1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_009291983.1	Gene:	olfcn1 / 793310	ZFINID:	ZDB-GENE-061117-2	Length:	855	Species:	Danio rerio

Alignment Length:	907	Identity:	177/907 - (19%)
Similarity:	326/907 - (35%)	Gaps:	251/907 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 QRNHGKIVLLGLFELSTSRGPRPDGLSELGAATMAVEHINR-KRLLPGYTLELVTNDTQCDPGVG 210
            :||..:|...| |:|...|.        :.:...||:.||: :.|||..:|.....|:...|...
Zfish    58 ERNMQRIKCTG-FDLRAFRW--------IQSMMFAVDEINKNEELLPHISLGYKIMDSCASPTNV 113

  Fly   211 VDRFFHAIYTQ-----------PSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSD 264
            :...|..:..|           |.|.:|...||:.|   .::|.::..:.:..||:.||...|||
Zfish   114 LRAVFSLVSEQKEQEFTSQCHLPLTALVAESGSSQS---LAVAGMLGPFRVPMVSYFSTCACLSD 175

  Fly   265 RREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATI 329
            |:::|.|:||:..|.....|..:.:::|||..:.....:.:.....::....|:|...: |.|.:
Zfish   176 RKKYPSFFRTIPSDFYQAKALASLVKQFGWTWIGALQSDNDYGRNGISAFTKEVEKMGV-CIAFV 239

  Fly   330 -----TFAATDFKEQLLLLRETDTRIIIGSFSQ-ELAPQILCEAYRLRMFG----ADYAWILHES 384
                 |:..:...|.:.:::|:..::|:....: :|.| ::.|.....:.|    |..||:   :
Zfish   240 GTILRTYPQSKITEVVEMIKESTVKVILAFVPEGDLYP-LMKEVVNRNITGIQWIASEAWV---T 300

  Fly   385 MGAPWWPDQRTACSNH-----------ELQLAVENLIVVS-THNSIVGN------------NVSY 425
            ...|..|:...:....           :|:..:||:...| |.::.|.:            |...
Zfish   301 AARPSTPEMFKSFGGTVGFVVRKMAMLKLRPYLENISPYSPTQSAFVSDFWETVVGCKPCLNCEP 365

  Fly   426 SGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQ 490
            |.  |...|.|:.....:....|.|......|::.
Zfish   366 SA--NSTLNGQMCTGQEKLTFTDKFFDVTQVRVTY------------------------------ 398

  Fly   491 YAPQTYDAVWAIALALRAAEEHWRRNEEQSK--LDGFDYTRSDMAWE-----FLQQMGKLHFLGV 548
               ..|.||:|||.|:... .:.:.:...||  |:....|...::.:     |:.:.|:..|...
Zfish   399 ---NVYQAVYAIAHAIHKV-LYCQGDNNLSKMCLNVSQITPKQVSDQLERVNFIDEYGENVFFDE 459

  Fly   549 SG--PVSFSGPDRVGTTAFYQIQRGLLEPVALYY------------------------------- 580
            :|  |.|:.       ...:|:.:|.::.|.:.|
Zfish   460 NGDPPASYE-------LINWQLNQGEVQHVTVGYFSKSPDGTYKLTIKEDNVHWSTENLIPKAVC 517

  Fly   581 ------------------------PATD--------ALDFRCPRCRPVKWHSGQVPIAKRVFKLR 613
                                    |..|        |.|  |..|....|.:      :|..|..
Zfish   518 SDTCPKGTRKAQIKGRPVCCFDCIPCADGSISNTTGAAD--CTLCPKEYWSN------ERRDKCL 574

  Fly   614 VATIAPLAFYT------IATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVY- 671
            |.||..|: ||      :..||..|.:|.:|.:...:|:|:...:|.::.:||::......|.:
Zfish   575 VKTIEFLS-YTETMGIILTALSLFGASLTVATMIVFIHYRETPIVKANNSELSSLLLSSLFFCFL 638

  Fly   672 ATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRT--GSVFKDK 734
            ..:..:|          :.....|..|.......|:|....:..||..|...|..|  |:....|
Zfish   639 CPLTFIG----------EPTHWSCMLRHTAFGLTFALCISCVLGKTIVVVTAFRATLPGNKLSGK 693

  Fly   735 M--LQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQ--VEVCRSQ 795
            .  :|...::.|...:.:|   :..||::..|            ...|:::.|..:  :..|.:.
Zfish   694 FGPVQQRAIVFLCTAIQIV---ICALWLLIKP------------PFPDKALRYDHKKIILECNTG 743

  Fly   796 HTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVYSVVITSAI-VVVLANLIS 858
            ....:.:.| .|.|||..:.:.:|:..|  |:| ..|::::|.   :|::|..|: |..:...||
Zfish   744 SDAGFYAAL-GYVGLLSTICLILAFLGR--KLPDNFNEAKFIS---FSMLIFCAVWVTFIPAYIS 802

  Fly   859 E--RVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVV 918
            .  :.|:| :.|.| ||:|....|..:|.||...|.              :|.|.|||:.|:
Zfish   803 SPGKYTVA-VEIFA-ILSSAFGLLLCIFAPKCFIIL--------------IKPERNTRKHVM 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	96/550 (17%)
		ANF_receptor	174..568	CDD:279440	84/448 (19%)
		7tm_3	633..889	CDD:278433	57/266 (21%)
olfcn1	XP_009291983.1	Periplasmic_Binding_Protein_Type_1	34..506	CDD:299141	95/507 (19%)
		ANF_receptor	75..473	CDD:279440	85/456 (19%)
		NCD3G	516..565	CDD:284890	6/50 (12%)
		7tm_3	601..834	CDD:278433	57/265 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910