Protein Alignment GABA-B-R3 and grm8a

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001289157.1
• Gene: grm8a / 792371
• ZFINID: ZDB-GENE-110421-2
• Length: 909
• Species: Danio rerio
• Alignment Length: 994
• Identity: 212/994 - (21%)
• Similarity: 358/994 - (36%)
• Gaps: 291/994 - (29%)

  Fly   148 RNHGKIVLLGLFELSTSRGPR---------PDGLSELGAATMAVEHINR-KRLLPGYTL------ 196
            |..|.|:|.|||.:. |||.|         ..|:..|.|...|::.||: ..|||..||
Zfish    40 RLDGDIILGGLFPVH-SRGERGVPCGELKKEKGIHRLEAMLFAIDLINKDPDLLPNVTLGARILD 103

  Fly   197 --------------------ELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESL 241
                                |...:|.:|..|   |:   .|:.:|. ::|.::|:|.|.|:..:
Zfish   104 TCSRDTYALEQSLTFVQALIERDGSDVRCANG---DQ---PIFAKPD-KIVGVIGAAASSVSIMV 161

  Fly   242 AKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEV 306
            |.::..:.|.|:|:.||:|.|||...:.:|.|.|.|||....|.:..:...||..|:|.:.....
Zfish   162 ANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMLDIVTAMGWNYVSTLASEGNY 226

  Fly   307 HSLAVNNLV-TELEAANISCAATITF----AATDFKEQLLLLRET-DTRIIIGSFSQELAPQILC 365
            ....|...| ...|...:..|.::..    .|.:|.:.:..|.|| :.|.||...:::...::|.
Zfish   227 GESGVEAFVQISREMGGVCIAQSLKIPREPRAGEFDKIIRRLLETPNARAIIMFANEDDIRRVLD 291

  Fly   366 EAYRLRMFGADYAWILHESMG---APWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSG 427
            .|.|....| .:.|:..:|.|   :|....:|.|          |..|.:....:.|
Zfish   292 SAKRSNQTG-HFLWVGSDSWGSKISPVIQQERVA----------EGAITILPKRATV-------- 337

  Fly   428 LNNHMFNSQLRKQS----------AQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGH 482
               ..|:...|.:|          |:| .::.||.                   :.|:.|...|.
Zfish   338 ---DAFDRYFRSRSLSNNRRNVWFAEF-WEENFGC-------------------KLGMHGKRPGS 379

  Fly   483 LFP----EAI---SQYAPQ-----TYDAVWAIALALRAAEEHWRRNE----------EQSKLDGF 525
            |..    |.:   |.|..:     ..|||:|:|.||     |....|          ..|.::|
Zfish   380 LKKCTGLEKVGRDSSYEQEGKVQFVMDAVYAMAHAL-----HRMHREYCFGYPGLCPRMSNING- 438

  Fly   526 DYTRSDMAWEFLQQMGKLHFLGVSG-PVSFS----GPDRVG---------TTAFYQI-------- 568
                    .|.|..:..:.|.|.:| ||.|:    .|.|..         :||.|::
Zfish   439 --------KELLGYIRNVSFNGSAGTPVVFNQNGDAPGRYDIFQYQITNKSTAEYKVIGQWTNKL 495

  Fly   569 -------------------------QRGLLEPVALYYPAT-----------DALDFRCPRC---- 593
                                     |.|..:.:....|..           .|.:|.|..|
Zfish   496 HLNVNVMRWRTGDPRLPASVCSVPCQMGERKKIVKGVPCCWHCERCEGYHFQASEFSCELCPYEQ 560

  Fly   594 RPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFN-LHFRKLKAIKLSSP 657
            ||.:..:|.|||.....:...|..|...|..:     :|| ||.:|:... :.:.....::.|..
Zfish   561 RPDRNRTGCVPIPIIKLEWHSAWAAVPVFVAV-----LGI-LATSFVVVTFVRYNDTPIVRASGR 619

  Fly   658 KLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHR 722
            ::|.:...|....||...|:    ...||     ..:|:.|...|..|...::.::..||.|:||
Zfish   620 EMSYVLLTGIFLCYAITFLM----IATPS-----LGICSFRRVFLGLGMCFSYAALLTKTNRIHR 675

  Fly   723 IFTR-TGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNL-------------- 772
            ||.: ..||...:.:.....:::...|:.|..|.|.:|...||.    |.:
Zfish   676 IFEQGKKSVAAPRFISPASQLVITFSLISVQLLGVFVWFAVDPP----HTVVDYGEQRTSDPMKA 736

  Fly   773 --TLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQY 835
              .|:...:|.|:       :|.           ..|..||:|.....|.:||.|. ...|:::.
Zfish   737 RGVLKCDISDLSL-------ICS-----------LGYSILLMVTCTVYAIKTRGVP-ETFNEAKP 782

  Fly   836 IGVSVYSV-VITSAIVVVLANLI--SERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDI 897
            ||.::|:. :|..|.:.:.....  :||:.:...|:|..:..|.:.:|.:|::||::.|
Zfish   783 IGFTMYTTCIIWLAFIPIFFGTAQSAERMYIQTTTLTISLSLSASVSLGMLYMPKVYVI------ 841

  Fly   898 IDPVIHSMGLKMECNTRRFVVDDRRELQYRVEV-----QNRVYKKEIQALDAEIRKLERLLESGL 957
               :.|.     |.|.      .:|:..::..|     ..::.:|.....:.|::  ..|.||
Zfish   842 ---IFHP-----EQNV------PKRKRSFKAIVTAATMSGKLVQKGSDRPNGEVK--TELCES-- 888

  Fly   958 TTTSTTTSSSTSLLTGGGH 976
            ..|:||.|:.|:.::...|
Zfish   889 METNTTFSTKTTYVSYSNH 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	119/567 (21%)
		ANF_receptor	174..568	CDD:279440	106/475 (22%)
		7tm_3	633..889	CDD:278433	60/276 (22%)
grm8a	NP_001289157.1	Periplasmic_Binding_Protein_Type_1	43..504	CDD:299141	117/524 (22%)
		ANF_receptor	73..477	CDD:279440	103/466 (22%)
		NCD3G	514..560	CDD:284890	7/45 (16%)
		7tm_3	595..840	CDD:278433	60/277 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910