DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vom2r5

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_017445187.1	Gene:	Vom2r5 / 679691	RGDID:	1585898	Length:	843	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	174/889 - (19%)
Similarity:	299/889 - (33%)	Gaps:	256/889 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 FELSTSRGPRPDGLSE--------------LGAATMAVEHINRK-RLLPGYTLELVTNDTQCDPG 208
            |.|.|..||.|:....              ......|.:.||:. .|||..:|........|:..
  Rat    48 FVLFTHEGPIPEDFYNDIINFRIPARKYEFFLVLLFATDEINKNPYLLPNMSLIFNIIFGLCEDT 112

  Fly   209 VGV-DRFFHAIYTQPSTRM------------VMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSP 260
            :|| |:.:  ::...::.:            |.|.|.:.   |.|| |:..|....::.|||.:|
  Rat   113 LGVLDKAY--LHQNSNSELFNYYCGINQLCDVDLTGPSW---TTSL-KLSIYSRTPKIFFGSFNP 171

  Fly   261 ALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISC 325
            .|||..:|||.|:..|.|:......::.:..|||..:.....:::.....:::|..|::...| |
  Rat   172 NLSDHDQFPYIYQIAAKDTYLFHGMVSLMFHFGWTWIGLVISDDDQGIQFLSDLREEMQRHAI-C 235

  Fly   326 AA-------TITFAATDFK--EQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAW-- 379
            .|       |:....|..|  :|.|:.......||.|..:..|.......||    .||...|
  Rat   236 LAFVNMIPETMQIYKTRVKIYDQQLMTSSAKVVIIYGEVNSTLELSFRRWAY----LGAQRIWIT 296

  Fly   380 ------ILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLR 438
                  |.|:...:..:.......::|...:||....:.:.:.|:...::|.|.|..:.||..:.
  Rat   297 TSQWDVITHKKDFSLDFSHGTVTFAHHHNDIAVFRNFMQTINTSMYPVDISQSMLQWNHFNCSIS 361

  Fly   439 KQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIA 503
            |...:   .|.|.........|.                    |.|...:|:.....|:||:|:|
  Rat   362 KNKKK---MDCFTFKNPLEWLIQ--------------------HTFDMVLSEEGYNLYNAVYAVA 403

  Fly   504 -----LALRAAEEHWRRNEE-----------QSKLDGFDYTRS-------------------DMA 533
                 |..:..|.  ::.||           .|.|...::|..                   .:.
  Rat   404 HTYHKLIFQQVES--QKMEEPKGLFTDCQQVTSLLKTIEFTNPVGELVDTKHKENQCATYDIFIT 466

  Fly   534 WEFLQQMG----------------KLH----FLGVSGPVSFSGPDRV----GTTAFYQIQRGLLE 574
            |.|.|.:|                :||    :..|:|.|....|..|    .|..|.:|
  Rat   467 WNFPQGLGLKVKIGSYFPCLPQSQQLHISEDWEWVTGGVLPQIPPSVCSMTCTAGFRKI------ 525

  Fly   575 PVALYYPATDALDFRCPRCRP------------VKW-HSGQVPIAKRVFKLRVATIAPLAFYTIA 626
                :...|....|.|.:|:.            ||. ......:.:.....||.|.       :|
  Rat   526 ----HQKETADCCFDCVQCQENEIANDTDMEQCVKCPDDSYANLEQSQCLQRVVTF-------LA 579

  Fly   627 TLSSVGIALAIAFLAFN----------LHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDH 681
            ....:|:||....|:|:          :.::....:|.::..||.|..:..:|.: ...||.:.|
  Rat   580 YEDPLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCF-LCSLLYIGH 643

  Fly   682 STLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQ----LI 742
            ..        ...|..:....:..|::|..::.|||..|...|..|   ..::.::.|.    :.
  Rat   644 PN--------QATCILQQTTFAIFFTVAISTVLAKTITVVTAFKLT---TPERRIKKIMIKGAIN 697

  Fly   743 LLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAY 807
            ||:....|:..:|..:|:|..|            ...||.:         :|:|.:.   ::...
  Rat   698 LLIPICTLIQLVLCAVWLVISP------------PFIDRDI---------QSEHGKV---IIICN 738

  Fly   808 KGLLL----VVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLA-FIT 867
            ||.::    |:|                   |:|    |:.:.|..|..||..:.:|...| |:|
  Rat   739 KGSVIAFHFVLG-------------------YLG----SLALGSFTVAFLARNLPDRFNEAKFLT 780

  Fly   868 ITALILTSTTATLCLLFIPKLHDIWARNDIIDPVI----HSMGL 907
            .:.|:..|...|    |:|..|....::.:|..|.    .|.||
  Rat   781 FSMLVFYSVWIT----FLPVYHSTRGKDMVIVEVFSILASSAGL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	106/534 (20%)
		ANF_receptor	174..568	CDD:279440	97/497 (20%)
		7tm_3	633..889	CDD:278433	53/274 (19%)
Vom2r5	XP_017445187.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910