DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vom2r1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_038946129.1	Gene:	Vom2r1 / 678740	RGDID:	1596944	Length:	842	Species:	Rattus norvegicus

Alignment Length:	853	Identity:	171/853 - (20%)
Similarity:	277/853 - (32%)	Gaps:	235/853 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINRK-RLLPGYTLELVTNDTQCDPGVGV-DR-FFHAIYTQPSTRMVMLLGSACSEVTESLA 242
            |.:.||:. .||...:|........|:..:|| |: :.|      ......||...|........
  Rat    84 ATDEINKNPYLLSNMSLIFSFIFGMCEDTMGVLDKAYLH------QNNYFDLLNYNCGRKKRCDV 142

  Fly   243 KVV-PYW----------NIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWG- 295
            |:. |.|          ...::.||..:|.|||..:|||.|:....|:......::.:..|.|.
  Rat   143 KLTGPSWKTSLKLSVNSRAPKIFFGPFNPNLSDHDQFPYIYQIATKDTYLLHGMVSLMFHFEWTW 207

  Fly   296 ---TVTTFSQNEEVHSLAVNNLVTELEAANISCAA-------TITFAATDFK--EQLLLLRETDT 348
               .:|...|..:.||    :|..|::...| |.|       :|....|.||  :|.|:......
  Rat   208 IGLIITDDDQGIQFHS----DLREEMQRHAI-CLAFVIMIPESIKLYNTKFKIYDQQLMTSSAKV 267

  Fly   349 RIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVS 413
            .||.|.....|........|.:    |...||....:      |..|...:..|......:|...
  Rat   268 TIIYGKMISTLELNFARWTYLV----ARRIWITTSKL------DVITYDKDFSLDFFHGTVIFAH 322

  Fly   414 THNSI--------VGNNVSY-------SGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAAT 463
            .||.|        :.|...|       .|..|| ||..:.|..              .::.....
  Rat   323 HHNDIATFRNFMQIINTSKYPVDISQSMGQWNH-FNCSISKNK--------------KKMDFFML 372

  Fly   464 QSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIA-----LALRAAEE------------ 511
            ::......:         |.|...:|:.....|:||:|:|     |..:..|.
  Rat   373 KNPMEWLTQ---------HTFDMVLSEEGYNLYNAVYAVAHTYHELIFQQVESQEMAKPKGLFTD 428

  Fly   512 ---------------------HWRRNEEQ-SKLDGFDYTRSDMAWEF----------------LQ 538
                                 :....|.| :|.|.|      :.|.|                ||
  Rat   429 CQQVASLLKTRVFTNPVGELVNMNHKENQCAKYDIF------IIWNFPNGLGLKVKIGSYFPCLQ 487

  Fly   539 QMGKLH----FLGVSGP--VSFSGPDRVGTTAF---------------YQIQRGLLEPVALYYPA 582
            |...||    :..|:|.  |..|......|..|               .|.|...:        |
  Rat   488 QSQHLHISEDWEWVTGETLVPSSVCSETCTAGFRKSHQKQTANCCFDCVQCQENEI--------A 544

  Fly   583 TDALDF-RCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFN--- 643
            .|..|. :|.||....:.:           |........|...:|....:|:||....|:|:
  Rat   545 NDTADMEQCVRCPDDSYAN-----------LEQTQCLQRAVTFLAYEDPLGMALGCMALSFSAIT 598

  Fly   644 -------LHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYL 701
                   :.:|....:|.::..||.|..:..:|.:...:|. :.|   |:.........|..::
  Rat   599 VLVLVTFVKYRDTPIVKANNRILSYILLISLVFCFLCSLLF-IGH---PNQATCILQQATFAIF- 658

  Fly   702 LSAGFSLAFGSMFAKTYRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP 764
                |::|..::.|||..|...|  |..|...: ||:..:...||:....|:..:|..:|:||.|
  Rat   659 ----FTVAISTVLAKTITVVTAFKLTTPGRRIR-KMMIKVATHLLIPICTLIQLVLCAIWLVTSP 718

  Fly   765 --MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKI 827
              ::|       :|.:....|:.     :|.......:..|| .|.|.|.:....:|:..|::.
  Rat   719 PFIDR-------DIQSEHGKVII-----ICNKGSVIAFHFVL-GYLGSLALGSFTVAFLARNLP- 769

  Fly   828 PALNDSQYIGVSV---YSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLH 889
            ...|:::::..|:   |||.||     .|....|.|..:..|.....||.|:...|..:|:.|.:
  Rat   770 DRFNEAKFLTFSMLVFYSVWIT-----FLPVYHSTRGKVMVIVEVFSILASSAGLLGCIFVQKCY 829

  Fly   890 DIWARNDI 897
            .:..|.|:
  Rat   830 VLLVRPDL 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	101/527 (19%)
		ANF_receptor	174..568	CDD:279440	96/504 (19%)
		7tm_3	633..889	CDD:278433	61/272 (22%)
Vom2r1	XP_038946129.1	Periplasmic_Binding_Protein_type1	45..500	CDD:415822	90/466 (19%)
		NCD3G	508..562	CDD:400103	11/61 (18%)
		7tmC_V2R_pheromone	582..833	CDD:320410	62/279 (22%)
		TM helix 1	583..607	CDD:320410	5/23 (22%)
		TM helix 2	619..640	CDD:320410	5/21 (24%)
		TM helix 3	649..671	CDD:320410	5/26 (19%)
		TM helix 4	697..713	CDD:320410	4/15 (27%)
		TM helix 5	740..763	CDD:320410	5/23 (22%)
		TM helix 6	775..797	CDD:320410	7/26 (27%)
		TM helix 7	802..827	CDD:320410	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910