DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r61

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001098528.1	Gene:	Vmn2r61 / 637873	MGIID:	1351347	Length:	865	Species:	Mus musculus

Alignment Length:	897	Identity:	163/897 - (18%)
Similarity:	311/897 - (34%)	Gaps:	250/897 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 AATMAVEHINRK-RLLPGYTLEL-----------------------VTNDTQCDPGVGVDRFFHA 217
            |...|:|.|||. .|||..|:..                       :.:...||  .|..|...|
Mouse    81 ALVFAIEEINRNPHLLPNTTIGYDIYNIPFTEKNILYHAFIWHTGKINSIPNCD--YGHKRKSPA 143

  Fly   218 IYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHN 282
            |.|.||......:|:           .:..:.|.|::||.....|::|.:|...|:....|:|.:
Mouse   144 ILTGPSWSTSAHIGT-----------FLQLYKIPQLTFGPFDSILNERGQFNSLYQMAPKDTSLS 197

  Fly   283 PARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFK-------EQL 340
            .|.:..:..|.|..|.....::......:::|...:|:..| |.|.:...:..:.       :.:
Mouse   198 LAIVLLMLHFRWYWVGLILPDDHRGIQILSDLRENMESHRI-CIAFLKMISGTWNAFSNALWKNM 261

  Fly   341 LLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLA 405
            ..:.|:...:|: .:...::.|.|.. :..::......|:|..|    |..|..:
Mouse   262 ETIEESSANVIL-IYGDIISVQGLMR-HIAQLLVTWKVWVLTSS----WDVDTHS---------- 310

  Fly   406 VENLIVVSTHNSIVGNNVSYSGLNNHM--FNSQLRKQSAQFHGQDGF------------GSGYGS 456
             :..:|.|.|.|::     :|..:..|  |...::..:...:.:|.:            .|.:..
Mouse   311 -DYFMVESFHGSLI-----FSHHHEDMVEFMKFVQTVNPYKYPEDNYLPKFWHLFFKCSFSKFDC 369

  Fly   457 RISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRA------------- 508
            ::......:.|.....|        |||..|:|:.....|:||:|:|.::..
Mouse   370 QLLENCQPNASLDLLPR--------HLFDPAMSEEGYNIYNAVYAVAYSVHEMNLQQIQTQPYAN 426

  Fly   509 AEE---------------------------HWRRNEEQSKLDGFDYTRSDMAWEFLQQMG---KL 543
            .||                           |..||.: |..|..::      |.|...:|   |:
Mouse   427 GEEMVFSPWQLHPFLKNTIMKSHVRGQTLIHGGRNLD-SMYDILNF------WNFPSGLGLKVKI 484

  Fly   544 HFLGVSGP--VSFSGPDRV--GTTAFYQIQRGLLEPV---ALYYPATDALDFRCPRCRP------ 595
            ....||.|  :.||..:::  ..|.|.:|.:.:...:   .....|.:.....|..|.|
Mouse   485 GTYSVSAPQGLQFSLCEQMIQWPTGFTKIPQSVCSEICRPGFRKAAQEGKAVCCFDCIPCADNEI 549

  Fly   596 ---------VKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNL------- 644
                     ||........:::.:.|: .:::.||:.     ..:|:||.|..|.|:|
Mouse   550 SNDTDVDQCVKCSESHYVNSEKNYCLQ-KSVSFLAYE-----EPLGMALTITSLCFSLLTAVVLV 608

  Fly   645 ---HFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGF 706
               ..|....:|.::..||.|..:.....:.:.:|.....:|         |.|..:.......|
Mouse   609 VFVKHRDTPIVKANNRTLSYILLLTLFISFLSSLLFVGQPNT---------TTCILQQTAFGILF 664

  Fly   707 SLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI----LLVGGLLLVDALLVTLWVVTDP--- 764
            :::..::.||...|...|.   ::...:|::.:.:.    .::....|:..::..:|::|.|
Mouse   665 TVSLSTVLAKAITVVIAFK---AIVPARMVRWLMVSRAPNFIIPICTLIQLIICGIWILTSPPFI 726

  Fly   765 ----MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLL--LVVGVY-MAWET 822
                ...|.|.:.                 ||....|..:.:||    |.|  |.:|.| ||:.:
Mouse   727 DQDTQAEHGHIII-----------------VCNMGSTVAFHTVL----GYLCSLALGSYTMAFLS 770

  Fly   823 RHVKIPALNDSQYIGVSV---YSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLF 884
            |::. ...|:::::..|:   :.|.||   .:.:.:....:|.:|....:  ||.|:.|.|.|.|
Mouse   771 RNLP-DTFNEAKFLSFSMQVFFCVWIT---FLPVYHSTKGKVMVAMEVFS--ILASSIALLGLNF 829

  Fly   885 IPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYK 936
            .||.:.|..|.:           |:.|      :|.|.....|..:.:.|.|
Mouse   830 APKCYIILLRPE-----------KISC------IDIRHTKYTRRNIHSNVVK 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	89/507 (18%)
		ANF_receptor	174..568	CDD:279440	87/482 (18%)
		7tm_3	633..889	CDD:278433	56/282 (20%)
Vmn2r61	NP_001098528.1	PBP1_Pheromone_receptor	36..506	CDD:107360	85/475 (18%)
		ANF_receptor	80..470	CDD:279440	76/433 (18%)
		NCD3G	515..566	CDD:284890	6/50 (12%)
		7tm_3	601..835	CDD:278433	51/272 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910