DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r4

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001372009.1	Gene:	Vmn2r4 / 637053	MGIID:	3648229	Length:	915	Species:	Mus musculus

Alignment Length:	912	Identity:	176/912 - (19%)
Similarity:	315/912 - (34%)	Gaps:	255/912 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 NHGKIVLLGLFELSTSRGPRPDGLSELGA--------------ATM--AVEHIN-RKRLLPGYTL 196
            || .:|:.|||.:.....|..|...|:.:              .||  .::.|| ||.:||.:||
Mouse    51 NH-SVVIGGLFPVHYRTMPTSDSDEEIESPMCEGFNFRGFRWMKTMIHTIKEINERKDILPNHTL 114

  Fly   197 --ELVTNDTQCDPGV--------GVDRFFHAIYTQPSTR------MVMLLGSACSEVTESLAKVV 245
              ::..|.......:        |.:.:      :|:.|      :|.::|:..|.::.:::::|
Mouse   115 GYQIFDNCFSITKAMESSSVFLTGQEEY------KPNWRNSTGKFLVGIIGAGGSTMSVAVSRIV 173

  Fly   246 PYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLA 310
            ....:.||.:.|:|...|:..:|||..||:..|...:.|.:..||.|||..|...:.:::.....
Mouse   174 GIHRVPQVGYASSSSIFSNDYQFPYILRTIPSDKFQSEAIVNLIRHFGWVWVGAIASDDDYGKYG 238

  Fly   311 VNNLVTELEAANISCAATITFAATDFKEQLLLL-----RETDTRIIIGSFSQELAP---QILCEA 367
            |.....|:|.||:..|.:.|.......|::.:.     ..|...|::.:...:|:|   :::...
Mouse   239 VKFFREEMERANLCVAFSETIPKVYSNEKMKIAVDAVKSSTAKVIVLYATDIDLSPFVLEVIHHN 303

  Fly   368 YRLRMFGADYAWILHESMGAP-------------------------------------------W 389
            ...|.:.|..|||....:..|                                           |
Mouse   304 ITDRTWIATEAWITSALIAKPEYFPYFGGTIGFAIPRSVIPGLKEFLYDVHPSKDPNDVLTIEFW 368

  Fly   390 -------WPDQRTACS-NHELQL-AVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLR-----KQ 440
                   ||:...|.: :|.:.: ..|:.:...:.....|........|.::..||||     :|
Mouse   369 QTAFNCTWPNSSVAYNVDHRVNMTGKEDRLYDMSDQLCTGEEKLEDLKNTYLDTSQLRITNNVRQ 433

  Fly   441 SAQF--HGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIA 503
            :...  |..|            ...|.|.|...|.           ...:...:...|..||...
Mouse   434 AVYLFAHAMD------------ILRQDDIREEYRE-----------KSVLESKSILDYIKVWPYM 475

  Fly   504 LALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSG------------ 556
            ..::......|:.|..|..|..:.:...:.|. :...|::.|:.| |...|:.
Mouse   476 KEIKFVTHDGRKIELGSNGDVLNGSYDIINWH-MDNTGEITFVKV-GEYKFTRSKYEFVLPKNST 538

  Fly   557 ----------PDRV-------GTTAFYQIQRGLL--EPVALY--YPATDAL------DFRCPRCR 594
                      ||.|       ||      ::|:|  :|:..:  .|.||..      ...|..|.
Mouse   539 LFWNTESSRLPDSVCTKVCPPGT------RKGILQGQPICCFDCIPCTDGYVSEKPGQRLCDPCG 597

  Fly   595 PVKWHSGQ----VPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLS 655
            ...|.:.:    ||  |.|..|  |....|.| |:..:|..|..:.:|.....:..|....:|.:
Mouse   598 ENDWSNAEKNKCVP--KHVEFL--AYEEALGF-TLVIISIFGALVVLAVTVVYVIHRHTPLVKAN 657

  Fly   656 SPKLSNITAVGC-IFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKT-- 717
            ..:||.:..:.. |.|.::::.:|...:          ..|..|...|:.||.|...|:..||
Mouse   658 DRELSFLIQMSLGITVLSSMLFIGKPCN----------WSCKTRQVTLALGFCLCLSSILGKTVS 712

  Fly   718 ----YRV----------HRIFTRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERH 768
                ||:          |.||.:.           |.||.:||     :..:.|.::|.:|
Mouse   713 LFFAYRISISKTRLISMHPIFRKL-----------IVLICVVG-----EIGVCTAYLVLEP---- 757

  Fly   769 LHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDS 833
             .:|...|...:..::::     | ::.:..:|..::.:..||.::.....:..|.     |.|:
Mouse   758 -PSLFKNIEPQNVKIIFE-----C-NEGSIEFLCSIFGFDVLLALLCFATTFVARQ-----LPDN 810

  Fly   834 QY------IGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIW 892
            .|      .|:.|:.:|..|.:...|:......|.:....    ||.|:...|..||:||...|.
Mouse   811 YYEGKCITFGMLVFFIVWISFVPAYLSTKGKFNVAVEIFA----ILASSYGLLGCLFLPKCFIIL 871

  Fly   893 AR 894
            .|
Mouse   872 LR 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	103/571 (18%)
		ANF_receptor	174..568	CDD:279440	92/522 (18%)
		7tm_3	633..889	CDD:278433	54/278 (19%)
Vmn2r4	NP_001372009.1	Periplasmic_Binding_Protein_type1	55..541	CDD:415822	93/516 (18%)
		NCD3G	549..602	CDD:400103	13/58 (22%)
		7tmC_V2R-like	622..874	CDD:320407	61/299 (20%)
		TM helix 1	623..647	CDD:320407	6/24 (25%)
		TM helix 2	659..680	CDD:320407	4/20 (20%)
		TM helix 3	689..711	CDD:320407	7/21 (33%)
		TM helix 4	736..752	CDD:320407	6/31 (19%)
		TM helix 5	779..802	CDD:320407	3/22 (14%)
		TM helix 6	814..836	CDD:320407	4/21 (19%)
		TM helix 7	841..866	CDD:320407	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910