DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r112

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001098045.1	Gene:	Vmn2r112 / 628185	MGIID:	3644292	Length:	857	Species:	Mus musculus

Alignment Length:	960	Identity:	174/960 - (18%)
Similarity:	315/960 - (32%)	Gaps:	285/960 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 IPPRSDWKYKRTKVKRRQQRLNSHSNLPGSTNASHAHHLLNLPPRQRYLK--VNQVFESERR--- 140
            |.||..||.||.:.|.|.|          .|..:.....:..|..:.|..  :|...::|.|
Mouse    21 IHPRCFWKMKRNENKDRNQ----------GTECTFVIQAVQQPVEKEYFSHILNIQTQTENRKYA 75

  Fly   141 ----MSPAEMQRNHGKIVLLGL-FELSTSRGPRPDGLSELGAATMAVEH--INRKRLLPGYTLEL 198
                .|..|:.||...:..:.| |:.|.......:.|       |::.|  :....:||.|..|
Mouse    76 LALAFSINEINRNPDLLPNMSLIFKFSAENCVWENKL-------MSLMHSSLQNYDILPNYLCE- 132

  Fly   199 VTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYW---NIVQVSFGSTSP 260
              ..|:|                     ||.|.|.....|.:|..::..:   ..:|:::|...|
Mouse   133 --EYTEC---------------------VMALTSLNWATTVTLYTILNNFMSEQFLQITYGPFHP 174

  Fly   261 ALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISC 325
            .|||..:|||.::..:..:|...|.::||..|||..|.....:.:.....::.|..|:|...: |
Mouse   175 VLSDHEKFPYLHQMASDHTSLALALVSFIIHFGWNWVGLVISDSDQGIQFLSYLRREMEKYTV-C 238

  Fly   326 AATITFAATDFKEQL---------LLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWIL 381
            .|.:.....:....:         ::...|:..||.|.....||     .::|:        |
Mouse   239 FAFVNMIPVNMNLYMSRAEVYYNQIMTSSTNVVIIYGDTDSTLA-----VSFRM--------W-- 288

  Fly   382 HESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHG 446
             ||:|.     ||...:..:..::      .|..:...||  .|...:....||::
Mouse   289 -ESLGI-----QRLWITTSQWDVS------PSMKDFTFGN--KYGTFDFQQHNSEI--------- 330

  Fly   447 QDGFGSGYGSRISIAATQ---------------SDSRRRRRRGVGGTSG-----GHLFPEAISQY 491
             .||.:...:..|:....               |.|:.:..:....:..     .|.|..|..:.
Mouse   331 -SGFKNFVQTLNSVKCPDEYLVELEWMHFNCEVSASKCKPLKNCSSSYSFDWLMEHTFDMAFIEK 394

  Fly   492 APQTYDAVWAIALALR----------AAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFL 546
            :...|:||:|.|.||.          ..:...:.|....|:|.     |....:|...:|.:..:
Mouse   395 SYYIYNAVYAFAHALHQFTFQKFDNLPKDNGKKHNYSCKKVDS-----SLRKTQFTNPVGDIVNM 454

  Fly   547 GVSGPVS--------FSGPDRVGTTAFYQIQRGLLEPVALYYP------ATDALDFRCPRCRPVK 597
            ...|.:.        ::.|..:|    .:|:.|:..|   |:|      .::.:         ::
Mouse   455 NQKGELQEEYDIFYIWNFPQGLG----LRIKIGMFSP---YFPNGQQVHLSEVM---------IR 503

  Fly   598 WHSGQVPIAKRVF---------KLRVATIAPLAFY------------------------------ 623
            |..|...:...|.         |..:..:|...|:
Mouse   504 WAKGSTQVPTSVCSADCGPGSRKFEMDGMAACCFHCKPCPENEISNETNVDNCVQCPEDQYANTE 568

  Fly   624 -------TIATLS---SVGIALAIAFLAFN----------LHFRKLKAIKLSSPKLSNITAVGCI 668
                   .:..||   .:|:||::..|.|:          :.......:|.::..|:.|..:..|
Mouse   569 QNHCIHKAVVFLSYEEPLGMALSLLSLFFSAFTTVILGVIVKHHNTPIVKANNRTLTYILLISLI 633

  Fly   669 FVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKD 733
            |.:...:|. :.|   |::...|....|..|.     |::|..::.|||..|...|..|.|
Mouse   634 FCFLCPLLF-IGH---PNSVTCFLQQITFGVV-----FTVALSTVLAKTITVVLAFKITAS---- 685

  Fly   734 KMLQDIQLILLVGG--------LLLVDALLVTLW-------VVTDPMERHLHNLTLEISATDRSV 783
               |.:....||.|        ..|:..::..:|       |..|....|.|.:.
Mouse   686 ---QRMMKYFLVSGASNYIILICTLIQVIVCAVWLGASPPFVDIDAQSEHGHIII---------- 737

  Fly   784 VYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVYSVVITS 847
                   ||.......:.|:| .|..||......:|:.:|:  :| |.|:::.|   .:|:::..
Mouse   738 -------VCHKGSVNAFYSIL-GYLALLSFGSFTLAFLSRN--LPGAFNEAKSI---TFSMLVFC 789

  Fly   848 AIVVVLANLISERVTLAFITITAL-ILTSTTATLCLLFIPKLHDIWARND 896
            ::.|....:.........:.:... .|.|:...|..:|:.|.:.|..|.|
Mouse   790 SVWVTFIPVYHSTKGKVMVAVEIFSTLASSAGILGCIFVSKCYTILFRPD 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	88/491 (18%)
		ANF_receptor	174..568	CDD:279440	79/445 (18%)
		7tm_3	633..889	CDD:278433	54/282 (19%)
Vmn2r112	NP_001098045.1	PBP1_Pheromone_receptor	41..504	CDD:107360	98/554 (18%)
		ANF_receptor	75..471	CDD:279440	85/471 (18%)
		NCD3G	513..564	CDD:284890	4/50 (8%)
		7tm_3	599..832	CDD:278433	50/271 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910