Protein Alignment GABA-B-R3 and Vmn2r93

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001098012.1
• Gene: Vmn2r93 / 627132
• MGIID: 3645591
• Length: 857
• Species: Mus musculus
• Alignment Length: 875
• Identity: 157/875 - (17%)
• Similarity: 289/875 - (33%)
• Gaps: 277/875 - (31%)

  Fly   177 AATMAVEHIN-RKRLLPG-------YTLELVTNDTQCDPGVGVDRFFHAI----YTQPSTRMVML 229
            |...|:|.|| ...|||.       |.:.....||..:.|:.:....|.:    ||....:....
Mouse    84 ALQFAIEEINGNPNLLPNISLGFDFYNVRFTEKDTLMNAGIWLTSHVHKMVFPNYTCGKKKFTAA 148

  Fly   230 LGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGW 294
            |..:....:..:..::..:...|::||...|.|||..::...|:....|:|...|.::.|..|.|
Mouse   149 LTGSSWMASAQIGTLLHLFKFPQITFGPYDPLLSDHSQYSSLYQMAPQDTSLTLAIVSLIVHFRW 213

  Fly   295 GTVTTFSQNEEVHSLAVNNLVTELEAANISCA------ATITFAATDFKEQLLLLRETDTRIIIG 353
            ..|.....::...:..:::...|:|...|..|      ||.|.....|.:.   :.||:..||.|
Mouse   214 LWVGLILPDDHKGNKILSDFREEMERKRICMAFVKMIPATWTSYFAKFWKN---MDETNVIIIYG 275

  Fly   354 ----------SFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVEN 408
                      :..|.|...|:              |:::              ..:|.|::: :.
Mouse   276 DIDSLEGLMRNIGQRLLTWIV--------------WVMN--------------TEHHVLEIS-DY 311

  Fly   409 LIVVSTHNSIVGNN-----------------------------------VSYSGLNNHMF-NSQL 437
            .::.|.|.|::..:                                   .|:|.:|.|:. |.|
Mouse   312 FMLDSFHGSLIFKHHYRENSDFTKFIQTVNPKNYPEDIYLPKLWYYFFKCSFSDINCHVLDNCQ- 375

  Fly   438 RKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAI 502
                              :..|:....|                |:|..|:::.:...|:.|:|:
Mouse   376 ------------------TNASLDVLPS----------------HIFDVAMTEESTSIYNGVYAL 406

  Fly   503 ALALRAAEEH-----------------WRRNE-----EQSKLDGFDYTRS-DMAWEFLQQMGKLH 544
            |.:|......                 |:.|.     |..|.....:.:: |:.::.|.......
Mouse   407 AHSLHEMRLQQLQVQPFENGEGMVFFPWQLNTFLKDIEMRKNRSLYWRQTIDVEYDILNLWNLPK 471

  Fly   545 FLGVS---GPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPA------------TDALDFR----- 589
            .||:.   |..|.:.|         |.|:..|....:.:||            :....||
Mouse   472 GLGLKVKVGSFSANAP---------QGQQLSLSEQMIQWPAIFSEIPQSVCSESCQSGFRKVSQE 527

  Fly   590 -----CPRCRP---------------VKWHSGQVPIAKR--VFKLRVATIA---PLAFYTIATLS 629
                 |..|.|               ||.........:|  ..:..|:.:|   ||..    .|:
Mouse   528 GKAICCYNCTPCAENEISNETDVDQCVKCPESHYANTERNNCLQKSVSFLAYDEPLGM----ALA 588

  Fly   630 SVGIALA---IAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSF 691
            |:.:.|:   :..:...|..|....:|.::..||.|..:...|.:    |..|:....|:
Mouse   589 SIALCLSTITVFVIGIFLRHRDTPIVKANNQGLSFILLITLTFCF----LCSLNFIGQPN----- 644

  Fly   692 ATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI----LLVGGLLLVD 752
            .:.|..:....:..|::|..::.||...|...|..:   |..:|::.:.:.    .::....|:.
Mouse   645 TSACILQQTTFAVAFTMALATVLAKAITVVLAFKVS---FPGRMVRWLMISRGPNYIIPICTLIQ 706

  Fly   753 ALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKG-------- 809
            .||..:|:.|                      |.|.::  :..||:....:|...||
Mouse   707 LLLCGIWMAT----------------------YPPFID--QDAHTEHGHIILLCNKGSAVAFHSV 747

  Fly   810 ----LLLVVGVY-MAWETRHVKIPALNDSQYIGVSV---YSVVITSAIVVVLANLISERVTLAFI 866
                ..|.:|.| ||:.:|::. ...|:|:::..|:   :.|.:|...|....|   .:|.:|..
Mouse   748 LGYLCFLALGSYTMAFLSRNLP-DTFNESKFLSFSMLVFFCVWVTFLPVYHSTN---GKVLVAME 808

  Fly   867 TITALILTSTTATLCLLFIPKLHDIWARND 896
            ..:  ||.|::|.|..:|.||.:.|..|.|
Mouse   809 VFS--ILASSSALLAFIFGPKCYIILLRPD 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	92/549 (17%)
		7tmC_GABA-B-like	621..892	CDD:320175	57/293 (19%)
		TM helix 1	621..645	CDD:320175	3/26 (12%)
		TM helix 2	657..678	CDD:320175	5/20 (25%)
		TM helix 3	696..720	CDD:320175	4/23 (17%)
		TM helix 4	741..761	CDD:320175	4/23 (17%)
		TM helix 5	797..823	CDD:320175	9/38 (24%)
		TM helix 6	832..855	CDD:320175	5/25 (20%)
		TM helix 7	862..887	CDD:320175	7/24 (29%)
Vmn2r93	NP_001098012.1	Periplasmic_Binding_Protein_type1	42..501	CDD:471960	83/492 (17%)
		NCD3G	509..562	CDD:462210	7/52 (13%)
		7tmC_V2R_pheromone	582..833	CDD:320410	60/296 (20%)
		TM helix 1	582..607	CDD:320410	5/28 (18%)
		TM helix 2	619..640	CDD:320410	6/24 (25%)
		TM helix 3	649..673	CDD:320410	4/23 (17%)
		TM helix 4	697..713	CDD:320410	3/15 (20%)
		TM helix 5	740..766	CDD:320410	5/25 (20%)
		TM helix 6	774..797	CDD:320410	5/22 (23%)
		TM helix 7	802..827	CDD:320410	8/26 (31%)