DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and Vmn2r90

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_001098009.1 Gene:Vmn2r90 / 626942 MGIID:3645076 Length:863 Species:Mus musculus


Alignment Length:854 Identity:160/854 - (18%)
Similarity:314/854 - (36%) Gaps:227/854 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 AATMAVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQ------PSTRMVM------ 228
            |...|:|.||:. .|||..||             |.| |::..:|:      |.|.:.|      
Mouse    81 ALLFAIEEINKNPHLLPNITL-------------GFD-FYNVRFTEKSILEGPLTWLTMLPYAIP 131

  Fly   229 -------------LLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSS 280
                         |.|::.| .:..:..::..:.|.|::||.....|:::.:..|.|:....|:.
Mouse   132 NYSCENKSNPPAALTGTSWS-TSAHIGTLLQLYKIPQLTFGPFDSILNNQEQLNYVYQMAPKDTF 195

  Fly   281 HNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATI--------TFAATDFK 337
            .:.|.::.:..|.|..|.....::...:..:::|...:|..|| |.|::        :|:...:|
Mouse   196 LSLAIVSLMLHFSWSWVGLIIPDDHKGTQILSDLRQVMERNNI-CIASVQMIPGIWNSFSNALWK 259

  Fly   338 EQLLLLRET--DTRIIIGSF--SQELAPQI--LCEAYRLRMFGADYAWILHESMGAPWWPDQRTA 396
             .|:..:|:  :..::.|..  .|.|...|  |...:::        |:|:    :.|..|    
Mouse   260 -SLVQTKESSANVTVVCGDIVSLQGLMRHIAQLLVTWKV--------WVLN----SQWDVD---- 307

  Fly   397 CSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHM--FNSQLRKQSAQFHGQDGF--------- 450
              .|.....:|:|     |.|.:     :|..:..|  |.:.:|..:...:.:|.:         
Mouse   308 --THSDYFMLESL-----HGSFI-----FSHHHEEMAEFTNFIRTVNPYKYPEDNYLPKFWYLFF 360

  Fly   451 ---GSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALAL------ 506
               .|.:..::......:.|.....|        :||...:|:.:...|:||:|:|.:|      
Mouse   361 KCSFSEFDCQLLENCQPNASLELLPR--------YLFDPVMSEESYNIYNAVYAVAYSLHEMNLQ 417

  Fly   507 -----RAAEEH------W------------RRNEEQSKLDGFDYTRSDM----AWEFLQQMGKLH 544
                 |.|...      |            .|....:.|||.....|:.    .|.|.:.:....
Mouse   418 QIQIQRYANGEKMVAFPWEVLPFLKNTLLKHRMRGHTDLDGKRKLDSEYDILNFWNFPKGLALKV 482

  Fly   545 FLG------------------VSGPVSFSG-PDRVGTTAF-----YQIQRGLLEPVALYY--PAT 583
            .:|                  :..|:.|:. |..|.:.:.     ..:|.|  ||...:|  |..
Mouse   483 KVGNFSPNAPHGQQLMLAEKRIQWPLMFTNIPQSVCSESCRPGFRKSVQEG--EPTCCFYCTPCA 545

  Fly   584 D-------ALDFRCPRCRPVKWHSGQVP--IAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAF 639
            |       .:| .|.:|....:.:.:..  :.|.|..|.......:|..|.|...||  ..|:..
Mouse   546 DNEISNETDMD-ECVKCPESHYANSEKNHCLQKSVSFLAYEDSLGIALTTTALCLSV--LTAVVL 607

  Fly   640 LAFNLHFRKLKAIKLSSPKLSN---ITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYL 701
            :.|..| |....:|.::..||.   :|.:.|..  ::::.:|..::          |.|..:...
Mouse   608 VVFVKH-RHTPIVKANNRTLSYTLLLTLIMCFL--SSLLFIGQPNT----------TTCILQQTA 659

  Fly   702 LSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI----LLVGGLLLVDALLVTLWVVT 762
            ....|::|..::.||...|...|..|   ..::.::.:.:.    .::....||..|...:|::|
Mouse   660 FGIFFTVALSTVLAKAITVVIAFKVT---VPNRKVRRLMISRAPNFIIPICTLVQLLFCGIWLIT 721

  Fly   763 DP--MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHV 825
            .|  ::::.|       |...:::.     :|.......:..|| .|...|.:|...:|:.:|::
Mouse   722 SPPFIDQNAH-------AEHGNIII-----LCNKGSAVAFHCVL-GYLCFLALVSYTLAFFSRNL 773

  Fly   826 KIPALNDSQYIGVSV---YSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPK 887
            . ...|:::::..|:   :.|.||   .:.:.:....:|.:|....:  :|.|:||.|.|:|.||
Mouse   774 P-DTFNEAKFLSFSMQVFFCVWIT---FLPVYHSTKGKVMVAMEVFS--MLASSTALLSLIFGPK 832

  Fly   888 LHDIWARND 896
            .:.|..|.|
Mouse   833 CYIILLRPD 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 98/542 (18%)
7tmC_GABA-B-like 621..892 CDD:320175 56/282 (20%)
TM helix 1 621..645 CDD:320175 7/23 (30%)
TM helix 2 657..678 CDD:320175 4/23 (17%)
TM helix 3 696..720 CDD:320175 4/23 (17%)
TM helix 4 741..761 CDD:320175 4/23 (17%)
TM helix 5 797..823 CDD:320175 6/25 (24%)
TM helix 6 832..855 CDD:320175 4/25 (16%)
TM helix 7 862..887 CDD:320175 8/24 (33%)
Vmn2r90NP_001098009.1 PBP1_pheromone_receptor 40..506 CDD:380588 84/477 (18%)
NCD3G 514..567 CDD:462210 12/55 (22%)
7tmC_V2R_pheromone 588..838 CDD:320410 57/286 (20%)
TM helix 1 588..612 CDD:320410 7/25 (28%)
TM helix 2 624..645 CDD:320410 4/22 (18%)
TM helix 3 654..678 CDD:320410 4/23 (17%)
TM helix 4 702..718 CDD:320410 3/15 (20%)
TM helix 5 745..771 CDD:320410 6/26 (23%)
TM helix 6 779..802 CDD:320410 4/25 (16%)
TM helix 7 807..832 CDD:320410 9/26 (35%)

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