DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and Vmn2r84

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_001074917.1 Gene:Vmn2r84 / 625068 MGIID:3643367 Length:849 Species:Mus musculus


Alignment Length:862 Identity:164/862 - (19%)
Similarity:274/862 - (31%) Gaps:255/862 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 AVEHINRK-RLLPGYTL-------------------ELVTNDT------QCDPGVGVDRFFHAIY 219
            |...||:. .|||..:|                   .::|||:      .||    :|.......
Mouse    84 ATNEINKNPDLLPNTSLVFSVMAGNCQDSLGNLDIQYMLTNDSLNYVNYVCD----IDDSCAIGL 144

  Fly   220 TQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPA 284
            |.||.:             .||...:..|. ..|.||..:|.|||...|||.::....|:..:..
Mouse   145 TGPSWK-------------TSLKLAIDSWT-PTVFFGPFNPKLSDHDHFPYVHQIATKDTHLSHG 195

  Fly   285 RIAFIRKFGWG----TVTTFSQNEEVHS------------LAVNNLVTELEAANISCAATITFAA 333
            .::.:..|.|.    .::...|..::||            ||..|::.|        ...|....
Mouse   196 MVSLMLHFRWTWIGLVISDDDQGVQLHSDLREESQRHGICLAFVNVIPE--------TMKIYMTR 252

  Fly   334 TDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACS 398
            .:..::.::.......||.|..:..|.......||    .||...||....     | |..|...
Mouse   253 GNMYDKQIMTSSAKVVIIYGEMNSTLEISFRRWAY----LGARRIWITTSQ-----W-DVITNKK 307

  Fly   399 NHELQLAVENLIVVSTHNSIVGN---------------NVSYSGLNNHMFNSQLRKQSAQFHGQD 448
            :..|.| ....:..:.|...:..               |:|.|.|..:.||..:.|.|.:   .|
Mouse   308 DFSLDL-FHGTVTFAHHKGWIAKFKNFMQTMNTSKYPINISQSVLRWNYFNCSVSKNSIK---MD 368

  Fly   449 GFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHW 513
            .|..  .:.:.:.|.                  |.:..|:|......|:||:|:|   ....||.
Mouse   369 HFTC--ENPLELTAL------------------HNYDMALSDEGYNLYNAVYAVA---HTYHEHI 410

  Fly   514 RRNEEQSKL--DGFDYTRSD----------------------------------MAWEFLQQMG- 541
            .:..|..|:  |..:||...                                  :.|.|.|.:| 
Mouse   411 LQQVESQKMAEDKGEYTECQQLAPLLKTRVFTNPVGEMVNMNHREYQCAEYDIFIIWNFPQGLGL 475

  Fly   542 ---------------KLHFL--------GVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPAT 583
                           :||..        |.|.|.|....  ..|..|.:|          :...|
Mouse   476 KVKIGSYFPCFPQSQQLHISEDLEWATGGTSVPSSMCSV--TCTPGFRKI----------HQKET 528

  Fly   584 DALDFRCPRCRPVKWHSGQVPIAKRV-------FKLRVATIAPLAFYTIATLSSVGIAL---AIA 638
            ....|.|.:| |....|.:..:.:.|       ..|........|...:|....:|:||   |::
Mouse   529 ADCCFDCVQC-PENEVSNETDMEQCVRCPDDQYANLEQTHCLQRAVSFLAYEDPLGMALGCMALS 592

  Fly   639 FLAFNL-------HFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCT 696
            |.|..:       .:|....:|.::..||.|..:..:|.:...:|. :.|..        ...|.
Mouse   593 FTAITILVLVTFVKYRDTPIVKANNCILSYILLISLVFCFLCSLLF-IGHPN--------QVTCI 648

  Fly   697 ARVYLLSAGFSLAFGSMFAKTYRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLW 759
            .:.......|::|..::.|||..|...|  |..|...:..|:......|::....|:..:|..:|
Mouse   649 LQQTTFGLFFTVAVSTVLAKTITVVMAFKLTTPGGRMRGMMMMTGAPKLVIPICTLIQLVLCGIW 713

  Fly   760 VVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWL----------SVLYAYKGLLLVV 814
            ::|.|            ...||.:         :|:|.:|.:          .|:..|.|.|.:.
Mouse   714 LLTSP------------PFIDRDI---------QSEHGKTVIFCNTGSVLAFHVVLGYLGSLALG 757

  Fly   815 GVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTAT 879
            ...:|:..|::. ...|:::::..|:  :|..|..:..|....|.|..:..:.....||.|:...
Mouse   758 SFTVAFLARNLP-DRFNEAKFLTFSM--LVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGL 819

  Fly   880 LCLLFIPKLHDIWARND 896
            |..:|:||.:.|..|.|
Mouse   820 LGCIFVPKCYAILVRPD 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 100/535 (19%)
7tmC_GABA-B-like 621..892 CDD:320175 58/292 (20%)
TM helix 1 621..645 CDD:320175 8/33 (24%)
TM helix 2 657..678 CDD:320175 5/20 (25%)
TM helix 3 696..720 CDD:320175 5/23 (22%)
TM helix 4 741..761 CDD:320175 4/19 (21%)
TM helix 5 797..823 CDD:320175 6/35 (17%)
TM helix 6 832..855 CDD:320175 4/22 (18%)
TM helix 7 862..887 CDD:320175 5/24 (21%)
Vmn2r84NP_001074917.1 PBP1_pheromone_receptor 46..500 CDD:380588 88/478 (18%)
NCD3G 508..561 CDD:462210 12/65 (18%)
7tmC_V2R_pheromone 581..833 CDD:320410 57/284 (20%)
TM helix 1 581..606 CDD:320410 6/24 (25%)
TM helix 2 618..639 CDD:320410 5/21 (24%)
TM helix 3 648..672 CDD:320410 5/23 (22%)
TM helix 4 697..713 CDD:320410 3/15 (20%)
TM helix 5 740..766 CDD:320410 5/25 (20%)
TM helix 6 774..797 CDD:320410 4/24 (17%)
TM helix 7 802..827 CDD:320410 5/24 (21%)

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