DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r116

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001098050.1	Gene:	Vmn2r116 / 619697	MGIID:	3646674	Length:	856	Species:	Mus musculus

Alignment Length:	995	Identity:	177/995 - (17%)
Similarity:	311/995 - (31%)	Gaps:	356/995 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 IPPRSDWKYKRTKVKRRQQRLNSHSNLPGSTNASHAHH---------LLNLPPRQRYLK--VNQV 134
            |.||..||.|:.:.:.|                   ||         .:..|.::.|..  :|..
Mouse    21 ISPRCFWKMKQNEYRDR-------------------HHGTGCIFLILAIQQPVKKEYFSHILNIQ 66

  Fly   135 FESERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPDGLSELGAATMAVEHINRK-RLLPGYTLEL 198
            ..:|          || |..|                     |...::..|||. .|||..:|..
Mouse    67 THTE----------NH-KYAL---------------------ALAFSIYEINRNPDLLPNMSLIF 99

  Fly   199 VTNDTQC--DPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTES-LAKVVPYW------------ 248
            :.:...|  :..:.:.||    ..|.|..:...|   |.|:|:. ||.....|
Mouse   100 IFSADSCEWESELSLIRF----GLQNSDNLPNYL---CEELTKCILALTNMNWATTVTLHTILSN 157

  Fly   249 ----NIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSL 309
                .::.:::|:..|||||..:|||.::..:..:|...|.::||..|||..|.....:.:....
Mouse   158 FLSDQLLHITYGTFHPALSDHEKFPYLHQMASDHTSLALALVSFIIHFGWNWVGLVISDSDQGIQ 222

  Fly   310 AVNNLVTELEAANISCAATITFAATDFKEQL---------LLLRETDTRIIIGSFSQELAPQILC 365
            .::.|..|:|...: |.|.:.....:....:         ::...|:..||.|.....||
Mouse   223 FLSYLRREMEKYTL-CFAFVNMIPLNINLYMSRAEVYYNQIMTSSTNVVIIYGDTDSTLA----- 281

  Fly   366 EAYRL-RMFGADYAWILHESMGAPWW---PDQRT----------ACSNHELQLAVENLIVVSTHN 416
            .::|: ...|....||....     |   |..:.          |...|..:::..... |.|.|
Mouse   282 VSFRMWESLGIQRLWITTSQ-----WDVSPSMKDFTFGNKYGTFAFEQHHSEISGFKHF-VQTLN 340

  Fly   417 SIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGG 481
            |:...:.....|....||.::.                .|:.......|.:...:...|
Mouse   341 SVKCPDEYLVKLEWMHFNCEVS----------------ASKCKTLKNCSSNHSLKWLMV------ 383

  Fly   482 HLFPEAISQYAPQTYDAVWAIALALRA-------------AEEHWRRNEEQSKLDGFDYTRSDMA 533
            |.|..|..:.:...|:||:|.|..|..             .:||   |....||  :.|.|
Mouse   384 HTFDMAFIEESYYIYNAVYAFAHVLHQFTFQKFDNLPKDNGKEH---NYSCKKL--YSYLR---- 439

  Fly   534 WEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQR--------------------GLLEPVAL 578
                    |.||:...|       |||......::|.                    |:..|
Mouse   440 --------KNHFINPVG-------DRVSMNQRDKLQEEYDIVYIWNFPQGLGLRVKIGMFSP--- 486

  Fly   579 YYP-------ATDALDFRCPRCRPVKWHSG--QVPIA---------KRVFKLRVATIAPLAFY-- 623
            |:|       :.|.|          ||..|  |||.:         .|  |.|:..:|...|:
Mouse   487 YFPNGQQVHLSEDML----------KWARGSTQVPTSMCSADCGPGSR--KFRMDGMAACCFHCK 539

  Fly   624 -----------------------------------TIATLS---SVGIALAIAFLAFN------- 643
                                               .:..||   .:|:||::..|.|:
Mouse   540 PCPENEISNETNVDNCVQCPEDQYANTEQNHCIRKAVVFLSYEEPLGVALSLLSLCFSAFTTVVL 604

  Fly   644 ---LHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAG 705
               :.......:|.::..|:.:..:..||.:...:|. :.|..        :..|..:.......
Mouse   605 GIFVKHHNTPIVKANNRTLTYLLLISLIFCFLCPLLF-IGHPN--------SATCILQQLTFGVV 660

  Fly   706 FSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLILLVGG--------LLLVDALLVTLWVVT 762
            |:::..::.|||..|...|....|       |.:....|:.|        .:|:..::..:|:..
Mouse   661 FTVSLSTVLAKTITVVLAFKIIAS-------QRMMKYFLISGAINYIIPICILIQVIVCAVWLRA 718

  Fly   763 DPMERHLHNLTLEISATDRSVVYQPQVEV-CRSQHTQTWLSVLYAYKG------------LLLVV 814
            .|                      |.|:: ..|:|.|.   ::..:||            .:|..
Mouse   719 SP----------------------PSVDIDAHSEHGQI---IIVCHKGSVNAFYCVLGYLAILAF 758

  Fly   815 GVY-MAWETRHVKIP-ALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITAL-ILTST 876
            |.: :|:.:|:  :| |.|:::.|   .:|:::..::.|....:.........:.:... .|.|:
Mouse   759 GSFTLAFLSRN--LPGAFNEAKSI---TFSMLVFCSVWVTFIPVYHSTKGKVMVAVEIFSTLASS 818

  Fly   877 TATLCLLFIPKLHDIWARND 896
            ...|..:|:||.:.|..|.|
Mouse   819 AGMLGCIFVPKCYTILFRQD 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	96/515 (19%)
		ANF_receptor	174..568	CDD:279440	89/449 (20%)
		7tm_3	633..889	CDD:278433	47/289 (16%)
Vmn2r116	NP_001098050.1	PBP1_Pheromone_receptor	41..503	CDD:107360	104/571 (18%)
		ANF_receptor	75..470	CDD:279440	91/480 (19%)
		NCD3G	512..563	CDD:284890	5/52 (10%)
		7tm_3	598..831	CDD:278433	43/278 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910