DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Grm8

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_071538.1	Gene:	Grm8 / 60590	RGDID:	619858	Length:	908	Species:	Rattus norvegicus

Alignment Length:	988	Identity:	209/988 - (21%)
Similarity:	364/988 - (36%)	Gaps:	277/988 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 MQRNH-----------GKIVLLGLFELST--SRG------PRPDGLSELGAATMAVEHINR-KRL 190
            |||.|           |.|:|.|||.:..  .||      .:..|:..|.|...|::.||: ..|
  Rat    28 MQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDL 92

  Fly   191 LPGYTL--------------------------ELVTNDTQC---DPGVGVDRFFHAIYTQPSTRM 226
            |...||                          |...:|.:|   ||         .|:|:|. ::
  Rat    93 LSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDP---------PIFTKPD-KI 147

  Fly   227 VMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRK 291
            ..::|:|.|.|:..:|.::..:.|.|:|:.||:|.|||...:.:|.|.|.|||....|.:..:..
  Rat   148 SGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTA 212

  Fly   292 FGWGTVTTFSQN---EEVHSLAVNNLVTELEAANISCAATITFAAT--DFKEQLLLLRET-DTRI 350
            .||..|:|.:..   .|....|...:..|:....|:.:..|.....  :|::.:..|.|| :.|.
  Rat   213 LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277

  Fly   351 IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMG---APWWPDQRTACSNHELQLAVENLIVV 412
            :|...:::...:||..|.:|...| .:.||..:|.|   ||.:..:..|          |..:
  Rat   278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIA----------EGAV-- 329

  Fly   413 STHNSIVGNNVSYSGLNNH-----MFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRR 472
                :|:....|..|.:.:     :.|::.....|:| .::.||...||.     .:.:|..::.
  Rat   330 ----TILPKRASIDGFDRYFRSRTLANNRRNVWFAEF-WEENFGCKLGSH-----GKRNSHIKKC 384

  Fly   473 RGVGGTSGGHLFPEAI---SQYAPQ-----TYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTR 529
            .|:          |.|   |.|..:     ..|||:::|.||        .|..:.:..|:....
  Rat   385 TGL----------ERIARDSSYEQEGKVQFVIDAVYSMAYAL--------HNMHKERCPGYIGLC 431

  Fly   530 SDMAW----EFLQQMGKLHFLGVSG-PVSFS-GPDRVGTTAFYQIQ------------------- 569
            ..|..    |.|..:..::|.|.:| ||:|: ..|..|....:|.|
  Rat   432 PRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLH 496

  Fly   570 ----------RGLLEPVAL----------------------------YYPATDALDFRCPRC--- 593
                      |....|.::                            |....|.|.  |..|
  Rat   497 LKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELS--CELCPLD 559

  Fly   594 -RP--------------VKWHS--GQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAI-AFL 640
             ||              ::|||  ..||:                  .||.|..:.....| .|:
  Rat   560 QRPNINRTGCQRIPIIKLEWHSPWAVVPV------------------FIAILGIIATTFVIVTFV 606

  Fly   641 AFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAG 705
            .:|    ....::.|..:||.:...|....|:...|       :.:|.|:.  :|:.|...|..|
  Rat   607 RYN----DTPIVRASGRELSYVLLTGIFLCYSITFL-------MIAAPDTI--ICSFRRIFLGLG 658

  Fly   706 FSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHL 769
            ...::.::..||.|:||||.: ..||...|.:.....:::...|:.|..|.|.:|.|.||..
  Rat   659 MCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH--- 720

  Fly   770 HNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQ 834
               |:......|::..:....|.:...:...|.....|..||:|.....|.:||.|. ...|:::
  Rat   721 ---TIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAK 781

  Fly   835 YIGVSVYSV-VITSAIVVVLANLI--SERVTLAFITITALILTSTTATLCLLFIPKLHDIWARND 896
            .||.::|:. :|..|.:.:.....  :|::.:...|:|..:..|.:.:|.:|::||::.|
  Rat   782 PIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYII----- 841

  Fly   897 IIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEV-----QNRVYKKEIQALDAEIRKLERLLESG 956
                :.|.     |.|.:      :|:..::..|     |:::.:|.....:.|::  ..|.||.
  Rat   842 ----IFHP-----EQNVQ------KRKRSFKAVVTAATMQSKLIQKGNDRPNGEVK--SELCESL 889

  Fly   957 LTTTSTTTSSSTS 969
            .|.||:|.::..|
  Rat   890 ETNTSSTKTTYIS 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	114/555 (21%)
		ANF_receptor	174..568	CDD:279440	101/451 (22%)
		7tm_3	633..889	CDD:278433	59/260 (23%)
Grm8	NP_071538.1	PBP1_mGluR_groupIII	44..504	CDD:107371	112/510 (22%)
		ANF_receptor	74..478	CDD:279440	102/454 (22%)
		Glutamate binding. /evidence=ECO:0000250	177..179		0/1 (0%)
		NCD3G	514..560	CDD:284890	5/47 (11%)
		7tm_3	595..840	CDD:278433	59/264 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910