Protein Alignment GABA-B-R3 and grm8b

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001274468.1
• Gene: grm8b / 569768
• ZFINID: ZDB-GENE-110421-3
• Length: 907
• Species: Danio rerio
• Alignment Length: 1012
• Identity: 200/1012 - (19%)
• Similarity: 354/1012 - (34%)
• Gaps: 282/1012 - (27%)

  Fly   123 PPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGPR---------PDGLSELGAA 178
            ||...|               |...|..|.|:|.|||.:. :||.|         ..|:..|.|.
Zfish    30 PPAPEY---------------AHSIRLDGDIILGGLFPVH-ARGERGAPCGELKKEKGIHRLEAM 78

  Fly   179 TMAVEHINR-KRLLPGYTL--------------------------ELVTNDTQCDPGVGVDRFFH 216
            ..|::.||: ..|||..||                          |..:.|.:|..|.      .
Zfish    79 LFAIDLINKDPDLLPNVTLGARILDTCSRDTYALEQSLTFVQALIERDSTDVRCASGE------Q 137

  Fly   217 AIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSH 281
            .|:.:|. :::.::|:|.|.|:..:|.::..:.|.|:|:.||:|.|||...:.:|.|.|.|||..
Zfish   138 PIFAKPD-KIIGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQ 201

  Fly   282 NPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLV-TELEAANISCAATITFAAT----DFKEQLL 341
            ..|.:..:...||..|:|.:.........|...| ...|...:..|.::.....    :|.:.:|
Zfish   202 AQAMLDIVTAMGWNYVSTLASEGNYGESGVEAFVQISRETGGVCIAQSLKIPREPRPGEFDKIIL 266

  Fly   342 LLRET-DTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLA 405
            .|.|| ..|.|:...:::...::|..|.|....| .:.|:..:|.|:             ::...
Zfish   267 RLLETPSARAIVMFANEDDIRRVLDAAKRNNQTG-HFLWVGSDSWGS-------------KISPV 317

  Fly   406 VENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRR 470
            |:...|.....:|:....|....:.:..:..|..........:.:...:|.::.:...:..|.|:
Zfish   318 VQQESVAEGAITILPKRASIEAFDRYFKSRSLSNNRRNVWFAEFWEENFGCKLGMHGKRPGSPRK 382

  Fly   471 --RRRGVGGTSGGHLFPEAISQYAPQTY----------DAVWAIALALRAAEEH----------- 512
              ....||..|               ||          |||:|:|.||......
Zfish   383 CTGLEKVGRDS---------------TYEQEGKVQFVMDAVYAMAHALHRMHRDLCSGYPGLCPR 432

  Fly   513 -----------WRRN-----------------EEQSKLDGFDYTRSDMAWEFLQQMG----KLHF 545
                       :.||                 :...:.|.:.|..::.:.|: :.:|    :||
Zfish   433 MSNIDGKELLGYIRNVSFNGSAKTLVVFNENGDAPGRYDIYQYQITNKSTEY-RIIGHWTDQLH- 495

  Fly   546 LGVSGPVSFSGPDRVGTT-AFYQIQRGLLEPVALYYPAT-----------DALDFRCPRC----R 594
            |.::.....||.|.:.|: .....|.|..:.:....|..           .|.:|.|..|    |
Zfish   496 LNINAMQWASGDDVMPTSVCSLPCQMGERKKIVKGVPCCWHCERCEGYHYQASEFTCQICPYELR 560

  Fly   595 PVKWHSGQVPIAKRVFKLRVAT---IAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSS 656
            |.:..:|..||.  :.||...:   :.|:....:..|::..:  .:.|:.:|    ....::.|.
Zfish   561 PDQNRTGCQPIP--IIKLEWHSPWAVVPVFIAILGILATTFV--VVTFVRYN----DTPIVRASG 617

  Fly   657 PKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVH 721
            .::|.:...|....|..         |.|........||:.|...|..|...::.::..||.|:|
Zfish   618 REMSYVLLTGIFLCYVI---------TFPMIGAPGVAVCSFRRIFLGLGMCFSYAALLTKTNRIH 673

  Fly   722 RIFTR-TGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVY 785
            |||.: ..||...:.:.....:::...|:.|..:.|.:|.|.||.    |.:          |.|
Zfish   674 RIFEQGKCSVAAPRFISPASQLVITFSLISVQLMGVFVWFVVDPP----HTV----------VDY 724

  Fly   786 QPQVEVCRSQHTQTWLSVL------------YAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGV 838
            ..|    |:|..:....||            ..|..||:|.....|.:||.|. ...|:::.||.
Zfish   725 GEQ----RTQDPKNARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVP-ETFNEAKPIGF 784

  Fly   839 SVYSV-VITSAIVVVLANLI--SERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDP 900
            ::|:. :|..|.:.:.....  .||:.:...|:|..:..|.:.:|.:|::||::.|
Zfish   785 TMYTTCIIWLAFIPIFFGTAQSEERMYIQTATLTVSLSLSASVSLGMLYMPKVYII--------- 840

  Fly   901 VIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTS 965
            ::|.                    :..|..:.|.:|                   .:.|.:|.|:
Zfish   841 ILHP--------------------EQNVPKRKRSFK-------------------AIVTAATMTN 866

  Fly   966 SSTSLLT--GGGHLKPEL----------TVTSGISQT 990
            ..:.|.:  ..|.:|.||          |.|:.:|.|
Zfish   867 KLSQLASERPNGEVKTELCESVDNSAPSTKTTYVSYT 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	104/541 (19%)
		ANF_receptor	174..568	CDD:279440	92/482 (19%)
		7tm_3	633..889	CDD:278433	60/271 (22%)
grm8b	NP_001274468.1	Periplasmic_Binding_Protein_Type_1	43..503	CDD:299141	98/498 (20%)
		ANF_receptor	73..477	CDD:279440	83/439 (19%)
		NCD3G	512..558	CDD:284890	8/45 (18%)
		7tm_3	594..839	CDD:278433	61/278 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910