Protein Alignment GABA-B-R3 and gpr158b

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_697068.4
• Gene: gpr158b / 568637
• ZFINID: ZDB-GENE-130530-875
• Length: 1286
• Species: Danio rerio
• Alignment Length: 1127
• Identity: 235/1127 - (20%)
• Similarity: 375/1127 - (33%)
• Gaps: 363/1127 - (32%)

  Fly   396 ACSNHELQLAVENLIVVSTH--NSIVGNNVS-----------YSGLNNHMF--NSQLRKQSAQFH 445
            |.|:..|| .|.:.:..:|:  |.::.:|.|           |..|.:.|.  |.::.:....||
Zfish   119 AASHSSLQ-GVLDTVAQATNFLNMLLQSNTSKEQHLRMDIQWYHALVSSMLEGNPKIHRAVVTFH 182

  Fly   446 GQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAE 510
            .:.  ....|.::.:.||:.:.|              :..:.:|..|..        .|..|.:|
Zfish   183 MES--PEAPGPQVFLQATRGEER--------------IVLQDLSTTARH--------RLKNRTSE 223

  Fly   511 EHW----RRNEEQSKL----------DGFDYTRSDMAWE--FLQ-QMGKL--------------- 543
            ..|    |...:..:|          .|:...:|.:.|.  :|: :.|:.
Zfish   224 SDWYNVFRDRNKHKRLVKSRAFPAAHGGYFLDKSHVKWSSPYLECEHGRFVPHWLLTISAGFYGL 288

  Fly   544 ------HFLGV---------------SGPVSFSGPDRVGTTAF----------------YQIQRG 571
                  .|.||               |....|:|..|...|:.                .|.:||
Zfish   289 KNKTAPEFRGVVRVDVNLQDVDIDQCSNSGWFAGTHRCNLTSMECNPIVGHGFVLDKYKCQCKRG 353

  Fly   572 LLEP--VALY-YPATD---------ALDFRCPRCRP-VKWHSGQVP-IAKRVFKLRVATIAPLAF 622
            ...|  |||. :..||         .|..||..||. .::.....| :|.....||:|.:
Zfish   354 FYHPSRVALNGFSKTDLGTYTDESWELSGRCLPCREGCEFCRDDTPCLAHEDTALRLAMV----- 413

  Fly   623 YTIATLSSVGIALAIAFLAFNL--HFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLP 685
                  |..|..:.:.|::..:  |||..|.||.|...|......|.:.:|..|::..|:.|.
Zfish   414 ------SFQGFCMLLDFISMVVVYHFRHNKRIKASGLILLEAILSGSVLLYFPVMIQYLNPSV-- 470

  Fly   686 SAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF-TRTGSVFKDKMLQDIQLILLVGGLL 749
                 |..:....|.||  ||::.:|::..|.|||.::| :||..  :...:...:::.|:..:|
Zfish   471 -----FRCILLRWVRLL--GFAIVYGTVILKLYRVLKVFLSRTAQ--RIPYMTSWRVLRLLAVIL 526

  Fly   750 LVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVV 814
            ||....:..|........:..:..::|..|...:    |..:|.   ..:|..::.|.:.|.|:.
Zfish   527 LVVMWFLAAWTSAVCQNHNTRHALIDIGVTPEGL----QFSMCL---LDSWDYMMAAAEFLFLLW 584

  Fly   815 GVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVL-----ANLISERVTLAFITITALILT 874
            |||:.:..|.|. .|.::.:|:.|::|:.::.|||..::     ..|..:.:.:.|...|.|
Zfish   585 GVYLCYAVRTVP-SAFHEPRYLAVAIYNELLISAIFHIIRFSLGTGLHPDWMLMLFFVHTHL--- 645

  Fly   875 STTATLCLLFIPKL-----HDIWARNDIIDPVIH---SMGLKMEC---------NTRRFVVDDRR 922
            :.|.||.||.|||.     |   ||.||......   .||....|         :......:|.|
Zfish   646 TVTVTLGLLLIPKFLFTGTH---AREDIATEAYEDELDMGHSGSCLNSSITSAWSEHSLDPEDIR 707

  Fly   923 ELQYRVEVQNRVYKKE--------IQALDAEIRKLERLLESGLTTTSTTTSSSTSL--LTGGGHL 977
            |...::..|..:||::        :|...:..|.|.|.|...:|....|.|...|.  ..|..|.
Zfish   708 EELKKLYSQLEIYKRKKMLANNPHLQKKRSSKRGLGRTLMRRITEIPETVSRQYSREDRDGSDHG 772

  Fly   978 KPELTVTSGISQTPAASKNRTPSISGILPNLLLSVLPPVIPRASWPSAEYMQ--------IP--- 1031
            ....|:.........:.|:|..|:...:.:|..|           .|.::..        :|
Zfish   773 SNRSTLRRNPFDPSHSGKSREESLKSKMFSLKRS-----------HSYDHTHDQGGQTNGVPGDK 826

  Fly  1032 MRRSVTFAS----------------QPQLEEA---------CLPAQDLINLRLAHQQATEAK--- 1068
            |..|.|.||                .|::|.|         |..|.       ||..|.|.|
Zfish   827 MENSTTEASLLDTLMGRRSNKKNPEVPKVELAESTESVPLVCKSAS-------AHNLAAEKKPVH 884

  Fly  1069 --TGLINRLRGIFS---RTTSSNKGSTASL--ADQKGLKA------------------------- 1101
              |.::.:...:.:   ..|....|.|.|:  |::|||||
Zfish   885 LRTSMLQKSLSVIASAREKTLGIAGKTHSVEDANKKGLKAREGTALSEVDESPECLPKMIISQSV 949

  Fly  1102 ---AFKSHMGLFTRLIPSSQTASCNAIYNNPNQDS-----------------IPSEASSHPN--- 1143
               ...|.||:..:.:..||.:.|    :.|.:..                 .|||..|..:
Zfish   950 EYTKTPSKMGIMKQQVSGSQPSIC----SEPGKSKELYDLSEVCPWEVEDLPTPSEGKSQKHVSI 1010

  Fly  1144 -GNHLKPIHRGSLTKSGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVKLLETKVNFQLPSNR 1207
             .|....|| ||..|||....|..|.                  ||             |.||||
Zfish  1011 APNETTTIH-GSSAKSGHKSQHKQKG------------------LG-------------QSPSNR 1043

  Fly  1208 RPSVVQQPPSLRERV--RGSPRFPHRILPPTCSLSALA-ESEDRPGDSTSILGSCKSIPRISLQQ 1269
            |.|        |::.  |...|.|...|..|....|.| ..||....:....|  .|..|||.::
Zfish  1044 RRS--------RDKTGERDEGRKPKSPLNLTTHKDASAWNFEDSSLQAMDTAG--LSPERISRKK 1098

  Fly  1270 ATSGGTWKSMETAGKSRLSLGD 1291
            :.:       .|.||.::.|.|
Zfish  1099 SVT-------PTDGKPKIFLSD 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	50/289 (17%)
		ANF_receptor	174..568	CDD:279440	40/255 (16%)
		7tm_3	633..889	CDD:278433	65/268 (24%)
gpr158b	XP_697068.4	7tm_3	420..659	CDD:278433	64/260 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910