DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and grm6a

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_021333966.1	Gene:	grm6a / 568484	ZFINID:	ZDB-GENE-060208-1	Length:	908	Species:	Danio rerio

Alignment Length:	967	Identity:	195/967 - (20%)
Similarity:	348/967 - (35%)	Gaps:	262/967 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 PGSTNASHAH-HLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGP---- 167
            |.|:...|:| |.:.:|                           |.|.|.|||.:. ||||
Zfish    43 PCSSVHQHSHPHSIKIP---------------------------GDITLGGLFPVH-SRGPAGVP 79

  Fly   168 -----RPDGLSELGAATMAVEHINR-KRLLPGYTL--------------------------ELVT 200
                 :..|:..|.|...|::.||. ..|||..||                          :..|
Zfish    80 CGEIKKEKGIHRLEAMLYALDQINSDPELLPNITLGARILDTCSRDTYALEQSLTFVQALIQKDT 144

  Fly   201 NDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDR 265
            :|.:|..|.      ..|..:|. |:|.::|::.|.|:..:|.|:..:.|.|:|:.||:|.|||.
Zfish   145 SDIRCSNGE------QPIIRKPE-RVVGVIGASGSSVSIMVANVLRLFEIPQISYASTAPELSDN 202

  Fly   266 REFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLV-TELEAANISCAATI 329
            ..:.:|.|.|.|||....|.:..::..||..|:|.:.........|:..| ...|...:..|.::
Zfish   203 NRYDFFSRVVPPDSYQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFVQISRETGGLCIAQSM 267

  Fly   330 TFAAT----DFKEQLLLLRETDTR--IIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAP 388
            .....    :|.:.:..|.||...  :||.:...:: .|:|..|.|..:.| .:.::..:|.||.
Zfish   268 KIPREPKPGEFDKIIKRLMETPNARGVIIFAHEDDI-KQVLEAARRSNLTG-HFKFVGSDSWGAK 330

  Fly   389 WWP--DQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFG 451
            ..|  ||......     ||          :|:....|..|.:.:.....|..........:.:.
Zfish   331 SSPILDQEDVAEG-----AV----------TILPKRASIDGFDQYFTTRSLENNRRNIWFAEFWE 380

  Fly   452 SGYGSRISIAATQSDSRRRRRRGVGGTS-GGHLFPEAISQYAPQTYDAVWAIALALRAAEEHW-- 513
            ..:..:::....:.|..:::..|....| ..|...|...|:   ..|||:|:|.||....:..
Zfish   381 DDFRCKLTRPGIKIDPEKKKCTGEERISRDSHYEQEGKVQF---VIDAVYAMAHALHNMHQELCP 442

  Fly   514 -------------------------------------RRNEEQSKLDGFDYTRSDMAWEFLQQMG 541
                                                 ...:...:.|.|.|..::.:....:.:|
Zfish   443 GATGVCDKMDPVEGRSLLNYIRAVNFNGSAGTAVLFNENGDAPGRYDIFQYQMTNTSSPGYRVIG 507

  Fly   542 -----------KLHFLGVSGPV-----SFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFR- 589
                       ::.:.|.|..:     ||  |.|.|...  ::.:|:  |...:....|...|:
Zfish   508 QWTNNLRLNVEEMQWTGGSRQIPDSVCSF--PCRSGERK--KMVKGV--PCCWHCELCDGYQFQA 566

  Fly   590 -------CP----------RCRP-----VKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVG 632
                   ||          .|||     ::|||   |.|          :.||....:..|::
Zfish   567 DEFNCEMCPFDMRPTLNRTACRPTPIIKLEWHS---PWA----------VIPLFLAILGILAT-- 616

  Fly   633 IALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTA 697
            :.:.|.|:.||    ....::.:..:||.:...|...:|....|:..:..|:         ||..
Zfish   617 LFIIITFIRFN----DTPIVRAAGRELSYVLLTGIFLIYLITFLMIAEPGTV---------VCAF 668

  Fly   698 RVYLLSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVV 761
            |..||..|.|:.:.:|..||.|::|||.: ..||...|.:.....:::...|:.|..:.|.:|..
Zfish   669 RRLLLGLGMSITYSAMLTKTNRIYRIFEQGKKSVTPPKFISPTSQLMITFVLISVQVVGVFVWFG 733

  Fly   762 TDPMERHLHNLTLEISATDRSVVYQPQVEVCRS--QHTQTWLSVL--YAYKGLLLVVGVYMAWET 822
            ..|..          :..|...:..|..|:.|.  :...:.||::  .:|..:|:|.....|.::
Zfish   734 VMPPH----------TTVDYEELRPPNPELARGILKCDMSDLSLICCLSYSIVLMVTCTVYAVKS 788

  Fly   823 RHVKIPALNDSQYIGVSVYSV-VITSAIVVVLANLI--SERVTLAFITITALILTSTTATLCLLF 884
            |.|. ...|:::.||.::|:. :|..|.|.:.....  :|::.:...|:|..:..|.:.:|.:|:
Zfish   789 RGVP-ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSTEKMFIQTTTLTVSMSLSASVSLGMLY 852

  Fly   885 IPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQA 941
            |||::.|         :.|.                    :..|:.:.|.:|..:||
Zfish   853 IPKVYVI---------IFHP--------------------EQNVQKRKRSFKAVVQA 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	106/541 (20%)
		ANF_receptor	174..568	CDD:279440	94/485 (19%)
		7tm_3	633..889	CDD:278433	60/263 (23%)
grm6a	XP_021333966.1	PBP1_mGluR_groupIII	60..522	CDD:107371	98/489 (20%)
		NCD3G	532..580	CDD:311495	11/53 (21%)
		7tmC_mGluR_group3	600..870	CDD:320413	68/334 (20%)
		TM helix 1	600..625	CDD:320413	7/36 (19%)
		TM helix 2	637..658	CDD:320413	5/20 (25%)
		TM helix 3	667..691	CDD:320413	8/23 (35%)
		TM helix 4	713..733	CDD:320413	4/19 (21%)
		TM helix 5	763..789	CDD:320413	6/25 (24%)
		TM helix 6	797..820	CDD:320413	6/22 (27%)
		TM helix 7	830..855	CDD:320413	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910