DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and grm5a

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001315639.1	Gene:	grm5a / 568406	ZFINID:	ZDB-GENE-090821-9	Length:	1173	Species:	Danio rerio

Alignment Length:	1359	Identity:	260/1359 - (19%)
Similarity:	449/1359 - (33%)	Gaps:	462/1359 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 SERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPD--------------GLSELGAATMAVEHINR 187
            ||||:    :....|.|::..||  |....|..|              |:..:.|....::.||.
Zfish    28 SERRV----LAHIPGDIIIGALF--SVHHQPPADKVHERKCGAVREQYGIQRVEAMMHTLDRINA 86

  Fly   188 KRL-LPGYTLELVTNDTQCDPGVGVDRFFHAI------------YTQPSTR-----------MVM 228
            ..| ||..||.....|:.....|.:::....|            ..:.||.           :|.
Zfish    87 DPLILPNITLGCEIRDSCWHSAVALEQSIEFIRDTLVSAEEEEGMAKCSTEGGGTPMKGKKPIVG 151

  Fly   229 LLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFG 293
            |:|...|.|...:..::..:||.|:::.:||..|||:..:.||.|.|..|:....|.:..::::.
Zfish   152 LIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKSLYKYFMRVVPSDAQQARAMVDIVKRYN 216

  Fly   294 WGTVTTFSQNEEVHSLAVNNLVTELEA-ANISCAATITFAATD----------FKEQLLLLRETD 347
            |..|:.      :|:.. |...:.:|| .:::....|..|.:|          |...|..||...
Zfish   217 WTYVSA------IHTEG-NYGESGMEAFKDMAAKEGICIAHSDKIYSNAGEQSFDRLLDKLRSHL 274

  Fly   348 TRI-IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPD--------QRTACSNHELQ 403
            .:. ::..|.:.:..:.:..|.|.|....::..:     |:..|.|        ||.|.....::
Zfish   275 PKARVVACFCEGMTVRGILMAMRRRRLVGEFLLV-----GSDGWADRYDVTDGFQREAAGGITIK 334

  Fly   404 LAVENLIVVSTHNSIVGNNVSYSGLNN--------HMFNSQLRKQSAQFHGQDGFGSGYGSRISI 460
            |   ....|:..:....|....:.:.|        |.|..:|:.     |.|:..      :.:.
Zfish   335 L---QSAYVTWFDDYYLNLQPDTNMRNPWFPEFWQHRFQCRLKG-----HPQESV------KYNK 385

  Fly   461 AATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQT-----YDAVWAIALALRAAEE-----HWRR 515
            ..|:.:|.|.                   |||..|     .:|::::|..|.|.::     :...
Zfish   386 TCTKKESLRH-------------------QYAQDTKMGFVINAIYSMAFGLHAMQKSLCPGYAGL 431

  Fly   516 NEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPV-----SFSGPDRVGTTAFYQI------- 568
            .|....:||         .:.|:.:.:.:|.||||.|     :...|.|.....|.|:
Zfish   432 CEAMRPIDG---------GKLLEFLMRTNFSGVSGEVVLFDENGDSPGRYEIMNFKQMSEEDYSY 487

  Fly   569 -------QRGL-------------------LEP-------------VALYYPATDAL-------D 587
                   .|||                   .:|             |:..:..|...       :
Zfish   488 IHVGSWDNRGLKMDDEEIWANSSAIIRSVCSDPCEKAQIKVIRKGEVSCCWTCTPCKENEFVFDE 552

  Fly   588 FRCPRCRPVKWHSGQVPIAKR--VFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLK 650
            :.|..|....|.:..:...:|  |..|:.....|:|....|.|   |:...|......:.|....
Zfish   553 YTCRACELGSWPTDDLTGCERIPVQYLQWGDPEPIAAVVFACL---GLLATIFVTLVFVRFHDTP 614

  Fly   651 AIKLSSPKLSNITAVG-CIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSL----AF 710
            .:|.||.:|..|...| |:....|..|:...|              .|..||...|..|    ::
Zfish   615 VVKSSSRELCFIILAGICLGYLCTFCLIAKPH--------------VAYCYLQRLGIGLSPAMSY 665

  Fly   711 GSMFAKTYRVHRIFTRTGSVFKDK----MLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHN 771
            .::..||.|:.||...:......|    |....||::....:|:...::|.|:::..|
Zfish   666 SALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILILIQLGIIVALFIMEPP------- 723

  Fly   772 LTLEISATDRSVVYQ-PQVE----VCRSQHTQTWLSVL--YAYKGLLLVVGVYMAWETRHVKIPA 829
                      .|:|. |.:.    :|.:    |.|.|:  ..|.|||::...:.|::||:|  ||
Zfish   724 ----------QVIYDYPSIREVHLICNT----TTLGVVAPLGYNGLLILSCTFYAFKTRNV--PA 772

  Fly   830 -LNDSQYIGVSVYSV-VITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIW 892
             .|:::||..::|:. :|..|.|.:......:.:|:.|    ::.|::||| ||.:|:||
Zfish   773 NFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCF----SVSLSATTA-LCCMFVPK----- 827

  Fly   893 ARNDIIDPVIHSMGLKMECNTR---------RFVVDD---------------------------- 920
                     ::.|..|.|.|.|         |..|.|
Zfish   828 ---------VYIMLAKPERNVRSAFTTSTVVRMHVGDGKSASAASRSSSLANLFRRRPSGTDTVS 883

  Fly   921 ---------RRELQYRVEVQNRV---YKKEIQALDAEIRK-----LERLLESGLTTTSTTTSSST 968
                     :.|..||..:..|:   .||:.:|....|.|     .:|..::|:.
Zfish   884 SNGKTVTWAQNERSYRPNLWKRISIHIKKKEEANQTAIIKPFSKGCDRPPDAGVK---------- 938

  Fly   969 SLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILPNLLLSVLPPVIPRASWPSAEYMQIPMR 1033
              |:..|..|.:        :.|...:.|||           |.||.:..|.|          |:
Zfish   939 --LSYDGSQKNQ--------RYPVTYRPRTP-----------SPLPTICQRPS----------MK 972

  Fly  1034 R-SVTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGSTASLADQK 1097
            | .|....:.|:  ..:|:  .:..||.||.::     :::::..:.|:       .||::.:
Zfish   973 RCDVEDGERAQV--VAIPS--YLTERLQHQPSS-----IMDQISCVVSQ-------FTANITE-- 1019

  Fly  1098 GLKAAFKSHMGLFTRLIPSS---QTASCNAIYNNPNQDSIPS-----EASSHPNGNHLKPIHRGS 1154
                       |.:.::|.|   ...:..|...||.:...||     :...||
Zfish  1020 -----------LNSMMLPGSPPGTAVNTTATSANPPRPCSPSYRHHQQERPHP------------ 1061

  Fly  1155 LTKSGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVKLLETKVNFQLPSNRRPSVVQQPPSLR 1219
             |...|:.| :....|..|...:  |..|....||               |:|     ..|.||.
Zfish  1062 -TTVTTYAD-VVAAANTTPRSAV--GIAGGIIAGG---------------SSR-----ASPASLF 1102

  Fly  1220 ERVRGS----------------PRFPHRILPPTCSLSALAESEDRPGDSTSILGSCKSI 1262
            :....|                |..|.|    ..|:.:::||...|.....:...|..|
Zfish  1103 DSTYDSSCAVRTTDFEDLGVLTPPSPFR----DSSVDSISESPTSPASELPLCEPCSPI 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	101/566 (18%)
		ANF_receptor	174..568	CDD:279440	88/460 (19%)
		7tm_3	633..889	CDD:278433	65/273 (24%)
grm5a	NP_001315639.1	PBP1_mGluR_groupI	31..502	CDD:107369	101/530 (19%)
		ANF_receptor	72..478	CDD:279440	87/459 (19%)
		NCD3G	514..563	CDD:284890	5/48 (10%)
		7tm_3	597..830	CDD:278433	65/288 (23%)
		GluR_Homer-bdg	1123..1173	CDD:287563	9/39 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910