DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and olfcd3

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:XP_696754.5 Gene:olfcd3 / 568337 ZFINID:ZDB-GENE-050712-4 Length:854 Species:Danio rerio


Alignment Length:866 Identity:185/866 - (21%)
Similarity:308/866 - (35%) Gaps:242/866 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 AVEHINRK-RLLPGYTL-------------------------ELVTNDTQCD--PGVGVDRFFHA 217
            |:|.||.. :||||.:|                         |...:||.|.  |.|..      
Zfish    89 AIEEINNNTQLLPGVSLGYKIYDSCGSIAQAIFSGMALMNGYEETLSDTSCSRPPAVNA------ 147

  Fly   218 IYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHN 282
                       ::|.:.|..|.:||.:...:::..:|..:|...||:|:.:..|:||:..|...:
Zfish   148 -----------IVGESNSSPTIALASIAGPFSLPVISHFATCACLSNRKRYASFFRTIPSDYYQS 201

  Fly   283 PARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAA---NISCAATITFAATDFKEQLL--- 341
            .|....::.|||..|.|.....:..:   |.:.|..|||   .|....:.....||.::|.|   
Zfish   202 RALAQLVKHFGWTWVGTVRSRSDYGN---NGIATFEEAAKKEGICIEYSEAILRTDPQDQFLKTV 263

  Fly   342 -LLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLA 405
             ::::...|:::...:......:|.|..:..:.|..  |:..||     |...||.....|    
Zfish   264 EVIKKGTARVVLAFVALRDFYPLLKEIAQQNITGLQ--WVGSES-----WITSRTVAETKE---- 317

  Fly   406 VENLIVVSTHNSIVG---NNVSYSGL-----NNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAA 462
                  .|..:..||   .||...||     |.|..:....|...:| .:..|...:.:|.|:..
Zfish   318 ------YSFLSGAVGFSIANVKLVGLLDFLVNVHPDHEPKNKLLKEF-WETTFQCSFNNRGSVGC 375

  Fly   463 TQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKL----- 522
            |.|:.....:...  |....|      :.|.:.|.||:|:|..|....:.: ::..:|||     
Zfish   376 TGSEKLANLQNEY--TDASEL------RIANKVYTAVYAVAHTLHNIFQDF-KSANRSKLKQPTP 431

  Fly   523 ------------------------DGFDYTRSDMA-WE-----FLQ-----------------QM 540
                                    .|....|.|:. |:     .||                 |:
Zfish   432 QMVLNYMKDVRFTVKTGEEIFFDTSGDPVARYDLVNWQPSGDGSLQFKNVGIYDSSLPSEKCLQV 496

  Fly   541 GKLHFLGVSG----PVSF---SGPDRVGTTAFYQIQRGLLEPVALY--YPA--------TDALDF 588
            .:.|.|....    |||.   |.|  :||..  .:|:|  .||..:  .|.        ||:.| 
Zfish   497 NQEHVLWADNSRQLPVSVCSESCP--LGTRK--AVQKG--RPVCCFDCIPCADGEISNNTDSSD- 554

  Fly   589 RCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAF-----YTIATLSSVGIALA--IAFLAFNLHF 646
             |..|....|.:      :|..|..:..|..|::     ..:...|.:|:.|.  ::|| |.|| 
Zfish   555 -CSPCDEEYWSN------ERKEKCVLKVIEFLSYTEIMGMVLCIFSFIGLLLTAMVSFL-FYLH- 610

  Fly   647 RKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFG 711
            ::...::.::.:||.:    .:|..:...|..|.....|:...     |..|.......|.|...
Zfish   611 KETPIVRANNSELSFL----LLFSLSLCFLCSLTFIGRPTEWS-----CMLRHTAFGITFVLCIS 666

  Fly   712 SMFAKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------MERH 768
            .:..||..|...|..|  ||... |.....|..|.|..|.|:..::..:|:...|      :..:
Zfish   667 CVLGKTIVVLMAFRATLPGSNVM-KWFGPTQQRLSVVFLTLIQVIICVVWLTVSPPFPYKNLSYY 730

  Fly   769 LHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALND 832
            ...:.||                |.......:.:|| .|.|||.|:...:|:..|  |:| ..|:
Zfish   731 REKIILE----------------CNLGSALGFWAVL-GYTGLLSVLCFILAFLAR--KLPDNFNE 776

  Fly   833 SQYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWAR 894
            :::|   .:|::|..|: :..:...:|.  :.|:| :.|.| ||:|:...|..:|.||.:.|.  
Zfish   777 AKFI---TFSMLIFCAVWLTFIPAYVSSPGKFTVA-VEIFA-ILSSSFGLLFCIFAPKCYIIL-- 834

  Fly   895 NDIIDPVIHSMGLKMECNTRR 915
                        ||.|.||::
Zfish   835 ------------LKPEKNTKK 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 111/530 (21%)
7tmC_GABA-B-like 621..892 CDD:320175 64/289 (22%)
TM helix 1 621..645 CDD:320175 6/30 (20%)
TM helix 2 657..678 CDD:320175 4/20 (20%)
TM helix 3 696..720 CDD:320175 5/23 (22%)
TM helix 4 741..761 CDD:320175 5/19 (26%)
TM helix 5 797..823 CDD:320175 8/25 (32%)
TM helix 6 832..855 CDD:320175 4/23 (17%)
TM helix 7 862..887 CDD:320175 9/24 (38%)
olfcd3XP_696754.5 PBP1_CaSR 46..503 CDD:380587 92/460 (20%)
NCD3G 511..564 CDD:462210 17/60 (28%)
7tmC_V2R_pheromone 585..835 CDD:320410 65/299 (22%)
TM helix 1 585..609 CDD:320410 6/24 (25%)
TM helix 2 621..642 CDD:320410 5/24 (21%)
TM helix 3 651..675 CDD:320410 5/23 (22%)
TM helix 4 699..715 CDD:320410 4/15 (27%)
TM helix 5 742..768 CDD:320410 8/26 (31%)
TM helix 6 776..799 CDD:320410 4/25 (16%)
TM helix 7 804..829 CDD:320410 9/26 (35%)

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