DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and grm4

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_021332579.1	Gene:	grm4 / 567181	ZFINID:	ZDB-GENE-030131-5781	Length:	916	Species:	Danio rerio

Alignment Length:	879	Identity:	189/879 - (21%)
Similarity:	334/879 - (37%)	Gaps:	216/879 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 RNHGKIVLLGLFELSTSRG---------PRPDGLSELGAATMAVEHINR-KRLLPGYTL------ 196
            |..|.|.|.|||.:. :||         .:..|:..|.|...|::.||. ..|||..||
Zfish    47 RIDGDISLGGLFPVH-ARGHEGKACGELKKEKGIHRLEAMLFALDRINNDHELLPNITLGARILD 110

  Fly   197 --------------------ELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESL 241
                                |....|.:|..|..      .|.|:|. |:|.::|::.|.|:..:
Zfish   111 TCSRDTHALEQSLTFVQALIEKDGTDVKCQGGGS------PIITKPE-RVVGVIGASSSSVSIMV 168

  Fly   242 AKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEV 306
            |.::..:.|.|||:.||:|.|||...:.||.|.|.||:....|.:..:|...|..|:|.:.....
Zfish   169 ANILRLFKIPQVSYASTAPELSDNTRYDYFSRVVPPDTYQAQAMVDIVRDMRWNYVSTVASEGNY 233

  Fly   307 HSLAVNNLVTE-LEAANISCAATITF----AATDFKEQLLLLRET-DTRIIIGSFSQELAPQILC 365
            ....|:..:.: .|..::..:.::..    ...:|.:.:..|.|. :.|::|...:::...::|.
Zfish   234 GESGVDAFIQKSREEGSVCISQSVKIPREPKPEEFDKIIKRLGENPNARVVIIFANEDDIRRLLQ 298

  Fly   366 EAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVG---------- 420
            .|.:....| .:.|:     |:..|..:.:...|.| ::|...:.::....||.|
Zfish   299 AAKKANQTG-HFLWV-----GSDSWGSKISPVLNQE-EMAEGAVTILPKRQSIRGFDRYFTSRTL 356

  Fly   421 ----NNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGT--- 478
                .|:.::....:.||.:|.:.:.:          .||.|.....|      .|.|...|
Zfish   357 ENNRRNIWFAEFWENNFNCKLSRHALK----------KGSGIKKCTNQ------ERIGKDSTYEQ 405

  Fly   479 SGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQ--------SKLDGFDYTRSDMAWE 535
            .|..:|          ..|||:|:|.||.      ..::|.        ||:|..|      ..:
Zfish   406 EGKVMF----------VIDAVYAMAHALH------NMHKELCPGKVGLCSKMDPVD------GAQ 448

  Fly   536 FLQQMGKLHFLGVSG-PVSFS-GPDRVGTTAFYQIQ----------------RGLLEPVALYYPA 582
            .|:::..:...|:.| ||.|: ..|..|....||.|                :..|...|:.:|.
Zfish   449 LLKKIRDVKIAGIGGNPVQFNENGDAPGRYEIYQYQIKNKTAEYKIIGHWTDQLYLNVRAMQWPG 513

  Fly   583 TD------------------------ALDFRCPRC-------------------RPVKWHSG--Q 602
            ..                        :..:.|.||                   ||.|.|:|  .
Zfish   514 GGRQVPTSICSQPCKPGWRKKIVKGMSCCWHCERCDGYQYQADLHTCKMCRFDLRPNKNHTGCQP 578

  Fly   603 VPIAKRVFKLRVATIAPLAFYTIATLSSVG-IALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVG 666
            :||.|..:....|.|..|    ||.|..:. :.:.:.|:.:|    ....:|.|..:||.:...|
Zfish   579 IPIVKLEWSSPWAVIPVL----IAILGIIATLFVVVTFIRYN----DTPIVKASGRELSYVLLTG 635

  Fly   667 CIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTR-TGSV 730
            ....|||..|       :.|..|  ..:|:.|...|..|.|:::.::..||.|::|||.: ..:|
Zfish   636 IFLCYATTFL-------MISTPD--VGICSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKMTV 691

  Fly   731 FKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVE--VCR 793
            ...:.:.....:::...|:.|..|.|.:|...||.:       ..|...|:..: .|::.  |.:
Zfish   692 SAPRFISPASQLIITFSLISVQLLGVCIWFAVDPSQ-------ALIDYEDQRTI-DPEMARGVLK 748

  Fly   794 SQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVL--AN 855
            ...:...|..|..|..||:|.....|.:||.|. ...|:::.||.::|:. :|..|.:.:.  .:
Zfish   749 CDISDLSLICLLGYSMLLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTS 812

  Fly   856 LISERVTLAFITITALILTSTTATLCLLFIPKLH 889
            ..:|::.:...|:|..:..|.:.:|.:|::||::
Zfish   813 QSTEKMYIQTTTLTISVSLSASVSLGMLYMPKVY 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	108/541 (20%)
		ANF_receptor	174..568	CDD:279440	97/453 (21%)
		7tm_3	633..889	CDD:278433	60/261 (23%)
grm4	XP_021332579.1	Periplasmic_Binding_Protein_Type_1	50..511	CDD:324556	110/513 (21%)
		NCD3G	520..569	CDD:311495	3/48 (6%)
		7tmC_mGluR4	589..916	CDD:320568	66/284 (23%)
		TM helix 1	589..614	CDD:320568	7/28 (25%)
		TM helix 2	626..647	CDD:320568	7/27 (26%)
		TM helix 3	656..680	CDD:320568	6/23 (26%)
		TM helix 4	702..722	CDD:320568	5/19 (26%)
		TM helix 5	752..778	CDD:320568	7/25 (28%)
		TM helix 6	786..809	CDD:320568	5/22 (23%)
		TM helix 7	819..844	CDD:320568	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910