DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and grm6b

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001073489.1	Gene:	grm6b / 565450	ZFINID:	ZDB-GENE-021120-2	Length:	905	Species:	Danio rerio

Alignment Length:	992	Identity:	205/992 - (20%)
Similarity:	360/992 - (36%)	Gaps:	253/992 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 HHLLNLPPRQRYLKVNQV-------FESERRMSPAEMQ----RNHGKIVLLGLFELSTSRGP--- 167
            ||.:...|:.....:..:       |..|.:.:.::.|    :..|.|.|.|||.:. ||||
Zfish    13 HHRIIRAPKPHVGSLIHIMWILTMGFTPESQAASSDTQPHSIKIEGDITLGGLFPVH-SRGPAGI 76

  Fly   168 ------RPDGLSELGAATMAVEHINR-KRLLPGYTL--------------------------ELV 199
                  :..|:..:.|...|::.||. ..|||..||                          :..
Zfish    77 PCGEVKKEKGIHRMEAMLYALDQINSDPDLLPNITLGARILDTCSRDTYALEQSLTFVQALIQKD 141

  Fly   200 TNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSD 264
            .:|.:|..|.      ..|..:|. |:|.::|::.|.|:..:|.|:..:.|.|:|:.||:|.|||
Zfish   142 NSDVRCSNGE------PPIIPKPE-RVVGVIGASASSVSIMVANVLRLFAIPQISYASTAPELSD 199

  Fly   265 RREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLV-TELEAANISCAAT 328
            ...:.:|.|.|.|||....|.:..::..||..|:|.:.........|:..: ...||..:..|..
Zfish   200 NNRYDFFSRVVPPDSFQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFIQISREAGGLCIAQA 264

  Fly   329 ITFAAT----DFKEQLLLLRET-DTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAP 388
            |.....    :|.:.:..|.|| :.|.:|...:::...::|..|.|..:.| .:.::..:|.||.
Zfish   265 IKIPREPRPGEFDKIIKRLMETSNARGVIIFANEDDIKRVLEAAKRANLTG-HFLFVGSDSWGAK 328

  Fly   389 WWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYS--GLNNHMFNSQLRKQSAQFHGQDGFG 451
            ..|     ..|.| .:|...:.::....||.|.:..::  .|.|:..|...    |:|...|
Zfish   329 ISP-----ILNQE-DVAEGAVTILPKRASIEGFDQYFTTRSLENNRRNIWF----AEFWEDD--- 380

  Fly   452 SGYGSRISIAATQSDSRRRRRRG---VGGTSGGHLFPEAISQYAPQTYDAVWAIALAL------- 506
              :..:::....:.|...|:..|   :|..||..  .|...|:   ..|||:|:|.||
Zfish   381 --FKCKLTRPGIRGDGGLRKCTGEERIGRDSGYE--QEGKVQF---VIDAVYAMAHALHSMHIDL 438

  Fly   507 -----------------------RAAEEHW---------RRNEEQSKLDGFDYTRSDMAWEFLQQ 539
                                   ||...:.         ...:...:.|.|.|..|:......:.
Zfish   439 CPGSMGVCDKMDPVDGRMLLTYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQLSNTTNPGYKL 503

  Fly   540 MGKL--HFLGVSGPVSFSG-----PDRVGTTAFYQIQRGLL---EPVALYYPATDALDF------ 588
            :|:.  |....:..:.:||     ||.|.:......:|..:   .|...:....|...|
Zfish   504 IGQWTNHLRLSAEDMQWSGGEKLVPDSVCSFPCESGERKRMVKGVPCCWHCELCDGYQFLLDEFN 568

  Fly   589 --RCP----------RCRP-----VKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALA 636
              .||          .|||     ::|.|   |.|          |.|:....:..|::.|:
Zfish   569 CDMCPFDMRPTPNRTACRPTPIIKLEWSS---PWA----------IIPVFLAVLGILATTGV--- 617

  Fly   637 IAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYL 701
               :|..:.|.....::.|..:||.:...|...:|....|:..:..|:         ||..|..|
Zfish   618 ---IATFIRFNDTPIVRASGRELSYVLLTGIFLIYLITFLMIAEPGTV---------VCAFRRLL 670

  Fly   702 LSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPM 765
            |..|..:::.:|..||.|::|||.: ..||...|.:.....:::...|:.|..|.:.:|....|.
Zfish   671 LGLGMCISYSAMLTKTNRIYRIFEQGKKSVTPPKFISPTSQLIITFILISVQLLGIFIWFGVVPP 735

  Fly   766 ERHLHNLTLEISATDRSVVYQPQVEVCR-----SQHTQTWLSVLYAYKGLLLVVGVYMAWETRHV 825
            ..::          |...:..|..|..|     .....:.:..|....||::...|| |.::|.|
Zfish   736 HTNV----------DFDELRPPNPEFARGILKCDMSDLSLIGCLSYSMGLMVTCTVY-AIKSRGV 789

  Fly   826 KIPALNDSQYIGVSVYSV-VITSAIVVVL--ANLISERVTLAFITITALILTSTTATLCLLFIPK 887
            . ...|:::.||.::|:. :|..|.|.:.  .:..:|::.:...|:|..:..|.|.:|.:|:|||
Zfish   790 P-ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTSQSTEKMFIQTTTLTVSMSLSATVSLGMLYIPK 853

  Fly   888 LHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERL 952
            ::.|         :.|.                    :..|:.:.|.:|...||
Zfish   854 VYVI---------IFHP--------------------EQNVQKRKRSFKAVAQA----------- 878

  Fly   953 LESGLTTTSTTTSSSTS 969
                 .|.||..|..:|
Zfish   879 -----ATVSTHLSQKSS 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	112/536 (21%)
		ANF_receptor	174..568	CDD:279440	100/477 (21%)
		7tm_3	633..889	CDD:278433	59/264 (22%)
grm6b	NP_001073489.1	PBP1_mGluR_groupIII	58..520	CDD:107371	106/490 (22%)
		ANF_receptor	88..492	CDD:279440	91/431 (21%)
		NCD3G	530..576	CDD:284890	7/45 (16%)
		7tm_3	611..856	CDD:278433	61/271 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910