DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and grm3

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001121815.1	Gene:	grm3 / 565256	ZFINID:	ZDB-GENE-061009-13	Length:	884	Species:	Danio rerio

Alignment Length:	917	Identity:	187/917 - (20%)
Similarity:	316/917 - (34%)	Gaps:	276/917 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SPAEMQRNHGKIVLLGLFELSTSRGPRPD---------GLSELGAATMAVEHINRK-RLLPG--- 193
            ||.:..:..|.:||.|||.:. .:|...|         |:..|.|...|::.||:. .||||
Zfish    22 SPRKEIKIDGDLVLGGLFPIH-EKGMGMDECGRINEDRGIQRLEAMLFAIDQINQDVALLPGVVL 85

  Fly   194 ------------YTLELV----------TNDTQ--CDPGVGVDRFFHAIYTQPSTRMVMLLGSAC 234
                        |.||..          .:||:  |..|      .:|:.......:..::|.:.
Zfish    86 GVHILDTCSRDTYALEQALEFVRASLTKVDDTEFICPDG------SYALQEDSPLAIAGVIGGSF 144

  Fly   235 SEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTT 299
            |.|:..:|.::..:.|.|:|:.|||..|||:..:.||.|||.||.....|....:|.|.|..|:|
Zfish   145 SSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRAFNWTYVST 209

  Fly   300 FSQNEEVHSLAVNNLVTELEAANISCAATI-----TFAATDFKEQLL--LLRETDTRIIIGSFSQ 357
            .:...:.....:.....:....|| |.||.     :.|.....|.::  ||::...|:.:.....
Zfish   210 VASEGDYGETGIEAFEQQARLRNI-CIATSEKVGRSSAKRSSYEAVVRQLLQKPTARVAVLFLRS 273

  Fly   358 ELAPQILCEAYRLRMFGADYAWILHESMGA----------------------------------- 387
            :.|.:::..|.||   .|.:.|:..:..||
Zfish   274 DDARELIAAAARL---NASFLWVASDGWGAQESIVKGNEFTADGAITLELAAHPIPDFNRYFQTL 335

  Fly   388 --------PWWPD---QRTACS----------------NHELQLAVENLIVVSTHNSIVGNNVSY 425
                    ||:.|   |:..||                :.||.:...|....|....:|  |..|
Zfish   336 TPQINHRNPWFKDFWEQKFQCSLGGTSATGAGTPKPPCDQELVIDKSNFEPESKIMFVV--NAVY 398

  Fly   426 SGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRR--------------RGVG 476
            :  ..|..:...|...|.           .:|:..|....|.|:..|              .|:.
Zfish   399 A--MAHALHRMQRTLCAN-----------TTRLCDAMRSLDGRKLYRDFLLHVNFRAPFSPAGLE 450

  Fly   477 GTSGGHLFPEAISQYAPQTYDAV-------------WAIALALRAAEEHWRRNEEQSKLDGFDYT 528
            .......:.:.:.:|....|.:|             ||.:|:|......|.|        |.|..
Zfish   451 SQVKFDAYGDGVGRYNIFNYQSVPGSDKFAYVQVGEWAESLSLNEGLIGWPR--------GADVP 507

  Fly   529 RSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRG-----LLEPVALYYPATDALDF 588
            .|..:                        |........::|.|     :..|...|....|  :|
Zfish   508 TSQCS------------------------DPCAPNEMKKMQAGEYCCWICTPCEPYEYLPD--EF 546

  Fly   589 RCPRCRPVKWH----SGQVPIAKRVFKLRVA-TIAPLAFYTIATLSSVG-IALAIAFLAFNLHFR 647
            .|..|.|.:|.    :|...:.:.......| .|.|:      :::.|| |...:.|:.|..| .
Zfish   547 TCMPCAPGQWPRPDLTGCYDLPEDYIMWEDAWAIGPI------SIACVGFICTLMVFIVFIRH-N 604

  Fly   648 KLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGS 712
            ....:|.|..:|..|..:|....|....:.....|.:         |||.|...|...|::.:.:
Zfish   605 DTPLVKASGRELCYILLLGVFMSYVMTFIFIAKPSPI---------VCTLRRLGLGTSFAVCYSA 660

  Fly   713 MFAKTYRVHRIFT--RTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLE 775
            :..||.|:.|||:  :.|...:.:.:.....:.:...|:.|..|||::|            |.:|
Zfish   661 LLTKTNRIARIFSGVKEGGAQRPRFISPSSQVFICLSLISVQLLLVSVW------------LLVE 713

  Fly   776 ISATDRSVVYQPQVEV---CRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPA-LNDSQYI 836
            :..|.|....:.:..|   |..:.:...:|:  :|..:|:|:....|::||  |.|. .|::::|
Zfish   714 VPGTRRFTTPEKRQTVILKCNVRDSSMLMSL--SYDVVLVVLCTVYAFKTR--KCPENFNEAKFI 774

  Fly   837 GVSVYSVVITSAIVVVLANLISERVTLAFITITALILTST-----TATLCL------------LF 884
            |.::|:..|               :.|||:.|  ..:||:     |.|:|:            :|
Zfish   775 GFTMYTTCI---------------IWLAFLPI--FYVTSSDYRVQTTTMCISVSLSGFVVLGCMF 822

  Fly   885 IPKLHDI 891
            .||:|.|
Zfish   823 APKVHII 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	108/570 (19%)
		ANF_receptor	174..568	CDD:279440	96/517 (19%)
		7tm_3	633..889	CDD:278433	62/278 (22%)
grm3	NP_001121815.1	PBP1_mGluR_groupII	31..493	CDD:107370	98/487 (20%)
		ANF_receptor	61..471	CDD:279440	84/434 (19%)
		NCD3G	508..556	CDD:284890	11/73 (15%)
		7tm_3	590..828	CDD:278433	62/280 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910