Protein Alignment GABA-B-R3 and grm2b

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001274476.1
• Gene: grm2b / 564461
• ZFINID: ZDB-GENE-060201-5
• Length: 874
• Species: Danio rerio
• Alignment Length: 894
• Identity: 174/894 - (19%)
• Similarity: 315/894 - (35%)
• Gaps: 264/894 - (29%)

  Fly   151 GKIVLLGLFELSTSRGPRPD--------GLSELGAATMAVEHINR-KRLLPG-----YTLELVTN 201
            |.:|:.|||.:........|        |:..|.|..:|::.||: .|:|||     :.|:..:.
Zfish    37 GDLVIGGLFPVHEKGKGTEDCGKINEERGIQRLEAMLLALDEINQDNRILPGLKLGAHILDTCSK 101

  Fly   202 DTQC----------------DPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNI 250
            ||..                .||.......:.:..:....:..::|.:.|:|:..:|.::..:.|
Zfish   102 DTYALEQSLAFVRASLTKVHQPGFICPDGSNPVPDELPLAISGVIGGSYSDVSIQVANLLRLFQI 166

  Fly   251 VQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLV 315
            .|:|:.|||..|||:..:.||.|||.||.....|....:|.|.|..|:|.:...:.....::...
Zfish   167 PQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAIAEILRYFNWTYVSTVASEGDYGETGIDAFQ 231

  Fly   316 TELEAANISCAATITFAAT----DFKEQLLLLRE-TDTRIIIGSFSQELAPQILCEAYRLRMFGA 375
            .|.....|..|.::..:.:    :::..:..|:: .:.:::|.....|.|.::|..|.|:.:
Zfish   232 QEARVRQICIATSVKVSRSVNQGNYETVIRSLQQKANAKVVILFTRSEDARELLAAAARMNV--- 293

  Fly   376 DYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQ 440
            .:.|:..:..||     |.:..  |:.:.|......:..        .|||   ...|.....|.
Zfish   294 TFIWVASDGWGA-----QESVV--HDSEKAANGAFTIEL--------ASYS---IREFEDYFTKL 340

  Fly   441 SAQFHGQDGFGSGY-----GSRISIAATQSDSRRRRRRGVGGTSGGHLF-PEAISQYAPQTYDAV 499
            :.:.:.::.:...|     |..:......|.|.|           ..|| ||:...:   ..:||
Zfish   341 TPELNTRNPWFREYWEHNFGCNLQDHGCASKSLR-----------NDLFKPESKIMF---VVNAV 391

  Fly   500 WAIALAL---RAA-----------------EEHWRRNEEQSKLDG-------------------- 524
            :|:|.||   |.|                 :..:|....::|.|.
Zfish   392 YAMAYALHNMRQAVCPNTTKVCDAMKPGNGKRFYREFILKTKFDAPFRPADTENVVRFTSLGDSL 456

  Fly   525 -----FDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVAL------ 578
                 |.|.:.|..:.:                     .:||..|     :||:...:|
Zfish   457 GRYNIFHYRKEDNKYVY---------------------RKVGYWA-----QGLVLNTSLVPWAGG 495

  Fly   579 YYPATDALDFRCPRCRPVKWHSGQ---------VPIAKRVFKLRVATIA-------PLAFYT--- 624
            ..|.:...|    .|:|.:..|.|         :|.....|.|...|..       |||..|
Zfish   496 VAPTSQCSD----PCQPNEAKSMQPGDVCCWICIPCQPHQFLLNEFTCVDCGFGQWPLANLTGCY 556

  Fly   625 ----------------IATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYAT 673
                            ..|::.:|:...:|.....|.......:|.|..:||.|...|.:..||.
Zfish   557 ELPEEYIHWSDAWAVGPVTIACLGMLCTLAVAGLFLRSNDTPVVKASGRELSYILLFGVLLCYAM 621

  Fly   674 VILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF-TRTGSVFKDKMLQ 737
            ..:    :...||     |.||..|...|...|::.:.::..||.|:.||| ....|..:.:.:.
Zfish   622 TFI----YIAKPS-----AFVCALRRLGLGTSFAVCYSALLTKTNRIARIFGGARDSAQRPRFIS 677

  Fly   738 DIQLILLVGGLLLVDALLVTLWVVTD---------PMERHLHNLTLEISATDRSVVYQPQVEVCR 793
            ....:.:...|:....|:..:|::.:         |..|.:  :||:.::.|.|::
Zfish   678 PASQVAICAALISAQLLVALVWLLVEAPGVRKEVGPDRRDV--VTLKCNSLDSSML--------- 731

  Fly   794 SQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVYSVVITSAIVVVLANLI 857
                     |..:|..:|:::..:.|::||  |.|. .|::::||.::|:..|
Zfish   732 ---------VSLSYNCILIILCTFYAFKTR--KCPENFNEAKFIGFTMYTTCI------------ 773

  Fly   858 SERVTLAF---ITITALILTSTTATLCL------------LFIPKLHDI 891
               :.|||   ..:||......|.|:|:            ||.||:|.|
Zfish   774 ---IWLAFQPIFYVTASDYRVQTTTMCISVSLSGSVVLGCLFAPKIHII 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	97/524 (19%)
		ANF_receptor	174..568	CDD:279440	87/471 (18%)
		7tm_3	633..889	CDD:278433	59/281 (21%)
grm2b	NP_001274476.1	PBP1_mGluR_groupII	37..487	CDD:107370	96/510 (19%)
		ANF_receptor	67..462	CDD:279440	81/429 (19%)
		NCD3G	499..547	CDD:284890	9/51 (18%)
		7tm_3	581..818	CDD:278433	59/282 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910