DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and gabbr2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001137515.1	Gene:	gabbr2 / 560267	ZFINID:	ZDB-GENE-060503-620	Length:	935	Species:	Danio rerio

Alignment Length:	1027	Identity:	307/1027 - (29%)
Similarity:	467/1027 - (45%)	Gaps:	203/1027 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 STSRGPRPDGLSELGAATMAVEHINRKRLLPGYTLELVTN--DTQCDPGVGVDRFFHAIYTQPST 224
            |.|:|..|       |..:|::||...|   .|:..|:|.  ||:||...|:..||.||...|
Zfish    70 SISQGIEP-------AVQLAIQHIRESR---QYSFSLITKIYDTECDNAKGLRAFFDAICYGP-- 122

  Fly   225 RMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFI 289
            :.:|:.|..|..||..:|:.:..||:||:||.:|:|.|:||:::|.|:|||..|::.|||.:.|:
Zfish   123 KHLMIFGGVCPSVTSIIAESLEGWNLVQLSFAATTPVLADRKKYPNFFRTVPSDNAVNPAVVKFL 187

  Fly   290 RKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRIIIGS 354
            ..:.|..|.|.:|:.:..|...|:|..|||.|:|..|.|.:| :.|....:..|::.|.|||||.
Zfish   188 NFYNWSRVGTLTQDVQRFSEVRNDLTNELEKADIQIADTESF-SNDPCVNVKKLKDNDVRIIIGQ 251

  Fly   355 FSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPD-QRTACSNHELQLAVENLIVVSTHNSI 418
            |.:.||.::.|.||.|.|:|:.|.||:.......||.. ..|.|:..:|..|:|..|.|.
Zfish   252 FDENLAAKVFCCAYNLNMYGSKYQWIIPGWYQGNWWEQANSTNCTTRKLLTAMEGYISVD----- 311

  Fly   419 VGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHL 483
                          |.....||.          .|...|......:..:|.|.::|| .||..|.
Zfish   312 --------------FEPLSAKQI----------KGISGRTPQEYEREYNRERDQKGV-ETSKFHG 351

  Fly   484 FPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGV 548
            |          .||.:|.||..|....|..|..|.......|.....::....|..|.:.:|.||
Zfish   352 F----------AYDGIWVIAKTLTRVMELLRHKERHDMYHNFTVDDREVGKMVLDVMNETNFFGV 406

  Fly   549 SGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVF-KL 612
            :|.|.|...:|:||..|.|.|.|....|..|....|.||......|    ..|..|...|.| :|
Zfish   407 TGQVMFRNGERMGTIKFTQFQEGQEVKVGEYNAIADVLDLINNTIR----FQGVEPPKDRTFVRL 467

  Fly   613 RVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILL 677
            :...|....:..::|::.:|:.:..|||.||:..|..:.||:|||.::|:..:|.:..||::.|.
Zfish   468 QRRQINVPLYSILSTITILGMLMGGAFLFFNIKNRNHRLIKMSSPYMNNLIILGGMLSYASIFLF 532

  Fly   678 GLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI 742
            |||.|.:...|  |.|:||.|.::|..|::.|||:|||||:|||.||...  ..|.|:::|.:|.
Zfish   533 GLDGSFVSDKE--FETLCTVRTWILIVGYTTAFGAMFAKTWRVHAIFKNV--KMKKKIIKDQKLF 593

  Fly   743 LLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAY 807
            ::|||:||:|..::..|.:.||::|.:...:||.....|.:..:|.:|.|.:.|...||.::|||
Zfish   594 IIVGGMLLIDLCILICWQIVDPLKRTVEEYSLEADPQGRDIAIRPFLEHCENTHMTIWLGIVYAY 658

  Fly   808 KGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALI 872
            ||||::.|.::|||||:|.|||||||:|||:|||:|.|...|...::.|..::..:.|..:..:|
Zfish   659 KGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVI 723

  Fly   873 LTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKK 937
            :..:|.||||:|:||.                    :...|........|.|::   .||:  ||
Zfish   724 IFCSTITLCLVFVPKF--------------------VTMRTNPDAATQNRRLKF---TQNQ--KK 763

  Fly   938 EIQALDAEIRKLERLLESGLTTTSTTT--SSSTSLLTG----GGHLKPELT--------VTSGIS 988
            |    |::            |:||.|:  .::||.|.|    ...|:.::|        ||..:.
Zfish   764 E----DSK------------TSTSVTSVNQANTSRLDGLQSDNHRLRMKITELDKELEEVTMQLQ 812

  Fly   989 QTPAASKNRTPSISGIL---PNLLLSV------------LPPVI---PRASWPSAEYMQIPMRRS 1035
            .||    .:||.|....   .|.:||:            |...:   |:|.|.||:..:|
Zfish   813 DTP----EKTPYIKQNHYQDANNILSIRNFTDGKDGEKSLKNHLEQKPQAQWGSADPSRI----- 868

  Fly  1036 VTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGSTASLADQKGLK 1100
                |:..||:...|  :.|..||:.|...                                 |.
Zfish   869 ----SRGPLEDINSP--EHIQRRLSLQLPI---------------------------------LH 894

  Fly  1101 AAFKSHMGLFTRLIPSSQTASCNAIYNNPNQDSIPSEASSHPNGNHLKPIHR 1152
            .|:...:|        ...|||::..::|         ||.|...|:.|.:|
Zfish   895 HAYLPSIG--------GVDASCSSPTSSP---------SSSPRHRHMPPSYR 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	136/430 (32%)
		ANF_receptor	174..568	CDD:279440	124/396 (31%)
		7tm_3	633..889	CDD:278433	105/255 (41%)
gabbr2	NP_001137515.1	PBP1_GABAb_receptor	58..440	CDD:107361	133/422 (32%)
		ANF_receptor	76..419	CDD:279440	122/395 (31%)
		7tm_3	488..739	CDD:278433	104/254 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	1	1.000	-	-		FOG0005571
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820