DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R3 and gabbr1b

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_005170159.1	Gene:	gabbr1b / 558708	ZFINID:	ZDB-GENE-060503-5	Length:	994	Species:	Danio rerio

Alignment Length:	852	Identity:	253/852 - (29%)
Similarity:	410/852 - (48%)	Gaps:	108/852 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 KIVLLGLFELSTSRGPRPDGLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRFF 215
            |:.:..||.:|   |..|.|.:.|.||.||::.:|::. :||.|.|||:..|:.||||......:
Zfish   165 KLYIGALFPMS---GGWPGGQACLPAAQMALDLVNKRTDILPDYELELIHYDSMCDPGEATKLLY 226

  Fly   216 HAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSS 280
            ..:||:| .::|::.|  ||.|:..:|:....||::.:|:||:|||||:|:.||.|:||....:.
Zfish   227 DLLYTEP-IKIVLMPG--CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATL 288

  Fly   281 HNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRE 345
            |||.|:...:|:.|..:.|..|..||.:..:::|...::.|.|..:...:| .||....:..|:.
Zfish   289 HNPTRVQLFQKWKWTKIATIQQTTEVFTSTLDDLEQRVKEAGIEISVRQSF-LTDPAVAVKNLKR 352

  Fly   346 TDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWW--PDQRTACSNHELQLAVE- 407
            .|.|||:|.|.:..|.::.||.|:.:::|..|.|.|.......|:  .|....|:..::..|||
Zfish   353 QDARIIVGLFYETEARKVFCEVYKEKLYGKKYVWFLIGWYADNWFKIKDPSINCTVEQMTEAVEG 417

  Fly   408 ---NLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRR 469
               ..||:....::.|    .|.|.:..|.:||..:
Zfish   418 HVTTEIVMLNPETVRG----ASNLTSQEFLAQLMSK----------------------------- 449

  Fly   470 RRRRGVGGTSGGHLFPEAIS--QYAPQTYDAVWAIALALRAA----EEHWRRNEEQSKLDGFDYT 528
                 :||.:     ||...  |.||..||||||:||||...    :...||      |:.|:|.
Zfish   450 -----LGGKN-----PEETGGFQEAPLAYDAVWALALALNKTVGPLKAKGRR------LEDFNYN 498

  Fly   529 RSDMAWEFLQQMGKLHFLGVSGPVSFSGP-DRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPR 592
            ..|:..|..:.:....|.||||.|.|... .|:..|...|:|.|..:.:. ||..|..
Zfish   499 NKDITAEIYRALNTSSFEGVSGHVVFDAQGSRMAWTLIEQLQGGSYKKIG-YYDMTKG------- 555

  Fly   593 CRPVKWHS-----GQVPIAKR---VFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKL 649
              .:.|:.     |..|.|.:   :.|.|.  ::...|.:::..:.:||.:.|..|.||::...:
Zfish   556 --NLSWYGNDRWIGSGPPADQTVVIQKFRY--LSQKLFVSVSVFAGLGILMGIVCLTFNIYNSNV 616

  Fly   650 KAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMF 714
            :.|:.|.|.|:|:|||||:...|.|..||:|  .|......|..||..|::||..|||||:||||
Zfish   617 RYIQNSQPYLNNMTAVGCMMALAAVFPLGID--GLHVRNSQFPVVCQFRLWLLGLGFSLAYGSMF 679

  Fly   715 AKTYRVHRIFTRTGSVFKDKMLQDIQ---LILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEI 776
            .|.:.||.:||:.... |||..|.::   |...||.||::|.|.:.:|.:.||:...:...|.|.
Zfish   680 TKIWWVHTVFTKKDEK-KDKRKQHLEPWKLYATVGVLLVIDILSLMIWQIVDPLHITVEKFTKEA 743

  Fly   777 SATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVY 841
            ...|...:.:|.::.|.|:...|||.|:|.||||||::|:::|:||:.|....:||.:.:|:::|
Zfish   744 PKGDVDELIEPLLQHCSSEKMNTWLGVVYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIY 808

  Fly   842 SVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMG 906
            :|.:...|...:..::|.:...:|...:..|:.|...||.:||:||:..:..|.:.......:|.
Zfish   809 NVSVLCMITAPVTMILSSKQDASFAFASLAIIFSVYITLVVLFVPKMRRLITRGEWQSDQQETMK 873

  Fly   907 LKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKL------ERLLESGLTTTSTTTS 965
            .....|..    |:.:..|  :|.:|:..:|.||..:..:.:|      .:.|.|....||....
Zfish   874 TGSSTNNN----DEEKSRQ--LERENKELQKIIQEKEERVSELRNQLSERQALRSRKRPTSNQNH 932

  Fly   966 SSTSLLT 972
            ||.|:.|
Zfish   933 SSPSIPT 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	132/446 (30%)
		ANF_receptor	174..568	CDD:279440	120/407 (29%)
		7tm_3	633..889	CDD:278433	93/258 (36%)
gabbr1b	XP_005170159.1	CCP	97..154	CDD:214478
		PBP1_GABAb_receptor	167..560	CDD:107361	132/458 (29%)
		ANF_receptor	183..540	CDD:279440	121/409 (30%)
		7tm_3	600..855	CDD:278433	92/257 (36%)
		DD_cGKI	895..>923	CDD:213458	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820