Protein Alignment GABA-B-R3 and NPR3

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001191304.1
• Gene: NPR3 / 4883
• HGNCID: 7945
• Length: 541
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 109/589 - (18%)
• Similarity: 184/589 - (31%)
• Gaps: 202/589 - (34%)

  Fly   138 ERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPDG-LSELGAATMAVEHINR--------KRLL-P 192
            ||...|.:      ||.:|.|.       |:.|. |..|.....|:|:..|        :||| |
Human    44 EREALPPQ------KIEVLVLL-------PQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPP 95

  Fly   193 GYTLELVTNDTQCDPGVG-------VDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNI 250
            |...::...|:.|    |       |||...|...:|.    ::||..|......:|::..:|::
Human    96 GTRFQVAYEDSDC----GNRALFSLVDRVAAARGAKPD----LILGPVCEYAAAPVARLASHWDL 152

  Fly   251 VQVSFGSTSPALSDR-REFPYFYRTVAPDSSHNPARIAFIRKFGW-------------------- 294
            ..:|.|:.:.....: .|:.:..|.....:......:|..|...|
Human   153 PMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTL 217

  Fly   295 ----------GTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTR 349
                      |..|:....:|...|.:.::|..::|:.                          |
Human   218 EGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASE--------------------------R 256

  Fly   350 IIIGSFSQELAPQILCEAYRLRMFGADYAWILHE-----SMGAPWWPDQRTACSNHELQLAVENL 409
            ::|...|.:....|:..|:|..|...|||:...|     |.|...|  :|....:.|.:.|..:|
Human   257 VVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSW--KRGDKHDFEAKQAYSSL 319

  Fly   410 IVVSTHNSI----------VGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQ 464
            ..|:...::          |.::|...|||
Human   320 QTVTLLRTVKPEFEKFSMEVKSSVEKQGLN----------------------------------- 349

  Fly   465 SDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTR 529
                               ..:.::.:....:||:....|||     |.......||.||
Human   350 -------------------MEDYVNMFVEGFHDAILLYVLAL-----HEVLRAGYSKKDG----- 385

  Fly   530 SDMAWEFLQQMGKLHFLGVSGPVSF-SGPDRVG---TTAFYQIQRGLLEPVALYYPATDALDFRC 590
                .:.:||.....|.|::|.||. :..||.|   ..|...::.|..|.:..|:......:.|
Human   386 ----GKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMR- 445

  Fly   591 PRCRPVKWHSGQVPIAKRVFKLRVAT------------IAPLAFYTIATLSSVGIALAIAFLAFN 643
            |.   ||:..|  |:..|:.:.|:..            :...|...|...:.:|..|.:||..|.
Human   446 PN---VKYPWG--PLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFR 505

  Fly   644 LHFR 647
            ..:|
Human   506 KKYR 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	87/499 (17%)
		ANF_receptor	174..568	CDD:279440	80/459 (17%)
		7tm_3	633..889	CDD:278433	5/15 (33%)
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	89/503 (18%)
		ANF_receptor	71..422	CDD:279440	79/454 (17%)
		TM_EphA1	476..507	CDD:214014	7/30 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910