Protein Alignment GABA-B-R3 and mGluR

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001259076.1
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Alignment Length: 1010
• Identity: 212/1010 - (20%)
• Similarity: 359/1010 - (35%)
• Gaps: 315/1010 - (31%)

  Fly   151 GKIVLLGLFEL-----STSRGPR--PDGLSELGAATMAVEHINR-KRLLPGYT-----LELVTND 202
            |.|:|.|||.:     ....||:  ..|:..|.|...|::.:|. ..:|||.|     |:..:.|
  Fly    43 GDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRD 107

  Fly   203 T----------------------QCDPGVGVDRFFHAIYTQPSTR-------MVMLLGSACSEVT 238
            |                      :|..|           :.|..|       :..::|.:.|.|:
  Fly   108 TYALNQSLQFVRASLNNLDTSGYECADG-----------SSPQLRKNASSGPVFGVIGGSYSSVS 161

  Fly   239 ESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQN 303
            ..:|.::..::|.|||..||:..|||:..|..|.|||.||:..:.|.:..::.|.|..|:|....
  Fly   162 LQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSE 226

  Fly   304 EEVHSLAVNNLVTELEAAN--ISCAATITFAATD--FKEQL-LLLRETDTRIIIGSFSQELAPQI 363
            .......:..|..|....|  |:.|..:..||.|  |...: .|.::.:.|.::.....|.|.:|
  Fly   227 GSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRI 291

  Fly   364 LCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGN------- 421
            |..|.|..: ...:.||..:.    |...|:..   ..|:...|..|.|...:.|:.:
  Fly   292 LQAAKRANL-SQPFHWIASDG----WGKQQKLL---EGLEDIAEGAITVELQSEIIADFDRYMMQ 348

  Fly   422 --------NVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISI-AATQSDSRRRRRRGVGG 477
                    |..::......||..|...|.:....:...| ..::|.: |.|:.|...|....||.
  Fly   349 LTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANS-TDNKIGVKAKTECDDSYRLSEKVGY 412

  Fly   478 TSGGHLFPEAISQYAPQTYDAVWAIALALR---------------------AAEEHWRR-----N 516
            ..      |:.:|:   ..|||:|.|.||.                     .:|..|.|     .
  Fly   413 EQ------ESKTQF---VVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDT 468

  Fly   517 EEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSG-PVSFSGPDRVG---------------TTAF 565
            :.|:..|..:|...:....:|..:.   |:.::| .|.|   ||.|               .::.
  Fly   469 KSQACPDMANYDGKEFYNNYLLNVS---FIDLAGSEVKF---DRQGDGLARYDILNYQRQENSSG 527

  Fly   566 YQIQ------RGLL-------------EPV-ALYYPATDAL------------------------ 586
            ||.:      .||.             :|. |...|....:
  Fly   528 YQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQGDTCCWICDSCESFEYVYD 592

  Fly   587 DFRCPRCRP------------------VKWHS--GQVPIAKRVFKLRVATIAPLAFYTIATLSSV 631
            :|.|..|.|                  :||:|  ..:|:|..:|
  Fly   593 EFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIF--------------------- 636

  Fly   632 GIAL---AIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFAT 693
            ||||   .|...|.| |...|  ::.|..:||.....|.:..|.....| :...|:.|
  Fly   637 GIALTSIVIVLFAKN-HDTPL--VRASGRELSYTLLFGILVCYCNTFAL-IAKPTIGS------- 690

  Fly   694 VCTARVYLLSAGFSLAFGSMFAKTYRVHRIF-TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVT 757
             |..:.:.:..|||:.:.::..||.|:.||| :.:.|..:.|.:.....:::...|:.:..|:..
  Fly   691 -CVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITM 754

  Fly   758 LWVVTDPMERHLHNLTLEISATDRSVVYQPQVEV---CRSQHTQTWLSVLYA--YKGLLLVVGVY 817
            :|:|.:|.....:              |..:.||   |:.|.    :|.|::  |..:|:.:...
  Fly   755 IWMVVEPPGTRFY--------------YPDRREVILKCKIQD----MSFLFSQLYNMILITICTI 801

  Fly   818 MAWETRHVKIPA-LNDSQYIGVSVYSV-VITSAIVVV---LANLISERVTLAFITITALILTSTT 877
            .|.:||  |||. .|:|::||.::|:. :|..|.|.:   ..|....:.|...|:|:   |:::.
  Fly   802 YAIKTR--KIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISIS---LSASV 861

  Fly   878 ATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQAL 942
            |.:| |:.||::.:         |.|.     :.|.|:..::            :.||::...|
  Fly   862 ALVC-LYSPKVYIL---------VFHP-----DKNVRKLTMN------------STVYRRSAAA- 898

  Fly   943 DAEIRKLERLLESGLTTT---STTTSSSTSLLTGG 974
                      :..|..|:   |.|.:..||.||||
  Fly   899 ----------VAQGAPTSSGYSRTHAPGTSALTGG 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	116/581 (20%)
		ANF_receptor	174..568	CDD:279440	103/491 (21%)
		7tm_3	633..889	CDD:278433	66/269 (25%)
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	115/533 (22%)
		ANF_receptor	72..518	CDD:279440	102/480 (21%)
		NCD3G	557..604	CDD:284890	6/46 (13%)
		7tm_3	638..873	CDD:278433	66/270 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I3495
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910