DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r9

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001098091.1	Gene:	Vmn2r9 / 435864	MGIID:	3643093	Length:	848	Species:	Mus musculus

Alignment Length:	851	Identity:	157/851 - (18%)
Similarity:	284/851 - (33%)	Gaps:	233/851 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKV 244
            |.:.||:. .|||..:|.:.....||.....|   .:..|:|.:.. |..:...|......:...
Mouse    83 ATDEINKNPDLLPNMSLIVWLLGGQCGDEWSV---LYKNYSQENIN-VEFINYDCLSPDCYIHLT 143

  Fly   245 VPYW----------NIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTT 299
            .|.|          ...::.||..:|.|||..:|||.::....|:..:.|.::.:..|.|..:..
Mouse   144 GPSWKTSLKMSIQSRTPKLFFGPFNPNLSDHDQFPYVHQVATKDTHLSHAMVSLMLHFRWAWIGL 208

  Fly   300 FSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRET--DTR---------IIIG 353
            ...:::.....:::|..|::...| |.|.:.....|.  |:.:.|.|  |.:         ||.|
Mouse   209 VISDDDQGIQFLSDLREEMQRHGI-CLAFVNMIPKDM--QIYMTRATIHDKQIMESTAKVVIIYG 270

  Fly   354 SFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRT--------------ACSNHELQL 404
            ..:..|....    .|....||...||....     | |..|              ...:|..::
Mouse   271 EMNSTLEVSF----RRWEDLGARRIWITTSQ-----W-DVITNKNDFSLDFFHGTVTFEHHHSEI 325

  Fly   405 A-VENLI--------VVSTHNSIVGNNV--------SYSGLNNHMFNSQLRKQSAQFH------G 446
            | .:|.:        .|:...||.|.|.        |||.:::..||:  ..:....|      .
Mouse   326 AKFKNFMKTMNTDKYPVNISQSIGGWNYFNCSTSMNSYSKMDHLTFNN--TSEWTALHNFDIVLS 388

  Fly   447 QDGFGSGYGSRISIAAT-------QSDSRRRR-RRG-------VGGTSGGHLFPEAISQYAPQTY 496
            ::|:.. |.:..::|.|       |.:|::.. |:|       |.......:|...:.:.....:
Mouse   389 EEGYNL-YNAVYAVAHTYHELILLQVESQQTEVRKGIFNDCQQVSSMLKSRIFTNPVGELVNMKH 452

  Fly   497 DAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMG----------------KLHF 545
                              |..:.::.|.|      :.|.|.|.:|                :||.
Mouse   453 ------------------RENQCAEYDIF------IIWNFPQGLGLKVKIGSYLPCFQQSQQLHI 493

  Fly   546 L--------GVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRC--------- 593
            .        |.|.|.|...   |..||.::         .::...|....|.|.||
Mouse   494 SEDLDWATEGTSVPSSMCS---VTCTAGFR---------KIHQNETADCCFDCDRCPENEVSNET 546

  Fly   594 ------------------------RPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIA 634
                                    |.|.:.:.:.|:.        .::..:|.:    ||::...
Mouse   547 ADMEQCVSCTGDKYANLEKTHCLQRAVSFLAYEDPLG--------MSLGCIALF----LSALTSL 599

  Fly   635 LAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARV 699
            :.:.|    :.::....:|.::..||.|..:..:|.:...:|. :.|..        ...|..:.
Mouse   600 VLVTF----VKYKDTPIVKANNRILSYILLISLVFCFLCSLLF-IGHPN--------QATCILQQ 651

  Fly   700 YLLSAGFSLAFGSMFAKTYRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVT 762
            ......|::|..::.|||..|...|  |..|...:. ||......|::....|:..:...:|:||
Mouse   652 TTFGVFFTVAISTVLAKTITVLMAFKLTTPGRRMRG-MLASGAPNLVIPICTLIQLVFCGIWLVT 715

  Fly   763 DP--MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHV 825
            .|  ::|            |....|...:.:|.......:..|| .|.|.|.:....:|:..|::
Mouse   716 SPPFIDR------------DTQSEYGKTIIICNKGSVIAFHFVL-GYLGSLALGSFTVAFLARNL 767

  Fly   826 KIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHD 890
            . ...|:::::..|:  :|..|..:..|....|.|.|:..:.....||.|:...|..:|:||...
Mouse   768 P-DRFNEAKFLTFSM--LVFCSVWITFLPVYHSTRGTVMVVVEVFSILASSAGLLGCIFLPKCCA 829

  Fly   891 IWARND 896
            |..|.|
Mouse   830 ILVRLD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	93/506 (18%)
		ANF_receptor	174..568	CDD:279440	91/484 (19%)
		7tm_3	633..889	CDD:278433	52/259 (20%)
Vmn2r9	NP_001098091.1	PBP1_Pheromone_receptor	40..499	CDD:107360	84/459 (18%)
		NCD3G	508..560	CDD:284890	9/63 (14%)
		7tm_3	595..828	CDD:278433	52/262 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910