Protein Alignment GABA-B-R3 and GABA-B-R2

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001287456.1
• Gene: GABA-B-R2 / 42561
• FlyBaseID: FBgn0027575
• Length: 1224
• Species: Drosophila melanogaster
• Alignment Length: 1185
• Identity: 349/1185 - (29%)
• Similarity: 554/1185 - (46%)
• Gaps: 201/1185 - (16%)

  Fly   163 TSRGPRPDGLSELGAATMAVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRM 226
            |.||..|       :..:|:.|:|.. ::|..|.|.:..|||||:..|||..||..:::.|:  .
  Fly    48 TGRGVMP-------SVKLALGHVNEHGKILANYRLHMWWNDTQCNAAVGVKSFFDMMHSGPN--K 103

  Fly   227 VMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRK 291
            |||.|:||:.||:.:||...:|::.|:|:..|.|..: :..||.|:|.|..:::.|..|:|.:::
  Fly   104 VMLFGAACTHVTDPIAKASKHWHLTQLSYADTHPMFT-KDAFPNFFRVVPSENAFNAPRLALLKE 167

  Fly   292 FGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRIIIGSFS 356
            |.|..|.|..|||..:||..|::|.:|:|..:....|.:| ..|..|.|..|||.|.|||:|:|:
  Fly   168 FNWTRVGTVYQNEPRYSLPHNHMVADLDAMEVEVVETQSF-VNDVAESLKKLREKDVRIILGNFN 231

  Fly   357 QELAPQILCEAYRLRMFGADYAWILHESMGAPWW-PDQRTACSNHELQLAVENLIVVSTHNSIVG 420
            :..|.:..||||:|.|:|..|.|::..:....|| ..|.:.||..|:..|:|..|:|........
  Fly   232 EHFARKAFCEAYKLDMYGRAYQWLIMATYSTDWWNVTQDSECSVEEIATALEGAILVDLLPLSTS 296

  Fly   421 NNVSYSGLNNHMF---NSQLR-KQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGG 481
            .:::.:|:....:   ..:|| .:.::|||
  Fly   297 GDITVAGITADEYLVEYDRLRGTEYSRFHG----------------------------------- 326

  Fly   482 HLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWE--FLQQMGKLH 544
                        .|||.:||.|||::...|     :.:..|..|||...|  ||  ||:.:....
  Fly   327 ------------YTYDGIWAAALAIQYVAE-----KREDLLTHFDYRVKD--WESVFLEALRNTS 372

  Fly   545 FLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRV 609
            |.||:|||.|...:|.......|.|.|.:|.:..|:.....||....  :||||.....|..:.:
  Fly   373 FEGVTGPVRFYNNERKANILINQFQLGQMEKIGEYHSQKSHLDLSLG--KPVKWVGKTPPKDRTL 435

  Fly   610 FKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATV 674
            ..:..:.:.|..:...|:.|.:|:.:|..|||||:.:|..:.||:|||.|:|:..|||:..|.::
  Fly   436 IYIEHSQVNPTIYIVSASASVIGVIIATVFLAFNIKYRNQRYIKMSSPHLNNLIIVGCMMTYLSI 500

  Fly   675 ILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDI 739
            |.|||| :||.|.. :|..:||||.::|.|||||:||:||:||:|||.||  |......|:::|.
  Fly   501 IFLGLD-TTLSSVA-AFPYICTARAWILMAGFSLSFGAMFSKTWRVHSIF--TDLKLNKKVIKDY 561

  Fly   740 QLILLVGGLLLVDALLVTLWVVTDPMERH------LHNLTLEISATDRSVVYQPQVEVCRSQHTQ 798
            ||.::||.||.:|..::|.|.:.||..|.      ||:..::      .|:..|:.|.|:|:|..
  Fly   562 QLFMVVGVLLAIDIAIITTWQIADPFYRETKQLEPLHHENID------DVLVIPENEYCQSEHMT 620

  Fly   799 TWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTL 863
            .::|::|||||||||.|.::|||||||.|||||||::||.|||:|.||......::.::|:|..|
  Fly   621 IFVSIIYAYKGLLLVFGAFLAWETRHVSIPALNDSKHIGFSVYNVFITCLAGAAISLVLSDRKDL 685

  Fly   864 AFITITALILTSTTATLCLLFIPKLHDIWA---RN--DIIDPVIHSMGLKMECNTRRFVVDDRR- 922
            .|:.::..|:..|||||||:|:||:..:..   ||  .::|..:.:....|..|.||    |..
  Fly   686 VFVLLSFFIIFCTTATLCLVFVPKVRLVLVELKRNPQGVVDKRVRATLRPMSKNGRR----DSSV 746

  Fly   923 -ELQYRV-EVQN---RVYK------KEIQALDAEIRKL---ERLLESGLTTTSTTTSSSTSLLTG 973
             ||:.|: :|:|   |..|      .|:|||   ||||   .|....|:|.|..:..
  Fly   747 CELEQRLRDVKNTNCRFRKALMEKENELQAL---IRKLGPEARKWIDGVTCTGGSNV-------- 800

  Fly   974 GGHLKP------------------------ELTVTSGISQTPAASKNRTPSISGILPNLLLSVLP 1014
            |..|:|                        |:|....::.|.....|   |...:...::...||
  Fly   801 GSELEPILNDDIVRLSAPPVRREMPSTTVTEMTSVDSVTSTHVEMDN---SFVSVQSTVMAPSLP 862

  Fly  1015 P------VIPRASWPSAEYMQIPMRRSVT--FASQPQLEEACLPAQDLINLRLAHQQATEAKTGL 1071
            |      ::...|...|..|..|:::.:.  .....|:::..|..|....::...||.......|
  Fly   863 PKKKKQSIVEHHSHAPAPTMMQPIQQQLQQHLQQHQQMQQQHLQQQQHQQMQQQQQQQQHHHRHL 927

  Fly  1072 INRLRGIFSRTTSSNKGSTASLADQKG---LKAAFKSHMGLFTRLIPS-SQTASCNAIYNNPNQD 1132
              ..|...|..|..|.||..|.|.::.   ..:..:......:|...| |||.:....|::.:::
  Fly   928 --EKRNSVSAQTDDNIGSITSTAGKRSGGDCSSMRERRQSTASRHYDSGSQTPTARPKYSSSHRN 990

  Fly  1133 SIPSEASSHPNGNHLKPIHRGS---LTKSGTHLDHLTKD------PNFLPIPTISGGEQGD-QTL 1187
            |..:.::|....:::.|..:.|   :.|:.|..||....      .||:    :|..:..| .||
  Fly   991 SSTNISTSQSELSNMCPHSKPSTPAVIKTPTASDHRRTSMGSALKSNFV----VSQSDLWDTHTL 1051

  Fly  1188 GGKYVKLLETKVNFQLPSN--------------RRPSVVQQPPSLRERVRGSPRFPHRILPPTCS 1238
              .:.|..::..|:..|..              ...|.:|:..|.:.|.:..|: |.:  ...|.
  Fly  1052 --SHAKQRQSPRNYASPQRCAEHHGGHGMTYDPNTTSPIQRSVSEKNRNKHRPK-PQK--GTVCQ 1111

  Fly  1239 LSALAESE-DRPGDS 1252
            ....:|.| |.|.:|
  Fly  1112 SETDSERERDPPPNS 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	130/434 (30%)
		ANF_receptor	174..568	CDD:279440	119/401 (30%)
		7tm_3	633..889	CDD:278433	119/261 (46%)
GABA-B-R2	NP_001287456.1	PBP1_GABAb_receptor	32..418	CDD:107361	130/434 (30%)
		ANF_receptor	52..396	CDD:279440	120/408 (29%)
		7tm_3	459..712	CDD:278433	119/262 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I3495
eggNOG	1	0.900	-	-		E1_KOG1055
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15091at50557
OrthoFinder	1	1.000	-	-		FOG0005571
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10519
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920