DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r11

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001372097.1	Gene:	Vmn2r11 / 384219	MGIID:	3643806	Length:	848	Species:	Mus musculus

Alignment Length:	836	Identity:	156/836 - (18%)
Similarity:	280/836 - (33%)	Gaps:	203/836 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKV 244
            |.:.||:. .|||..:|.......||:...||   ....|:|.:.. |..:...|......:...
Mouse    83 ATDEINKNPDLLPNISLIFWLFGGQCEDEWGV---LDTNYSQNNIN-VKFINYDCLSPNCYIDLT 143

  Fly   245 VPYW----------NIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTT 299
            .|.|          ...:|.|||.:|.|||..:|||.::....|:..:.|.::.:..|.|..:..
Mouse   144 GPSWKTSLKLSIQSRTPKVFFGSFNPNLSDHDQFPYVHQVATKDTLLSHAMVSLMLHFRWTWIGM 208

  Fly   300 FSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFK---------EQLLLLRETDTRIIIGSF 355
            ...:::.....:::|..|::...| |.|.:.....:.:         ::.::.......||.|..
Mouse   209 VISDDDQGIQFLSDLREEMQRHGI-CLAFVNMIPENMQIYMTRAKIYDKQIMESTAKVAIIYGEM 272

  Fly   356 SQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVG 420
            :..|....    .|....|....||....     | |..|..::..|.. ....:....|:|.:.
Mouse   273 NSSLEVSF----RRWEDLGVRRIWITTSQ-----W-DVITNKNDFSLDF-FHGTVTFEHHHSEIA 326

  Fly   421 N---------------NVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRR 470
            .               |:|.|.|..:.||......|.             |::......:.|.
Mouse   327 KFKNFMQTINTDKYPVNISESILGWNYFNCSTSMNSY-------------SKMDHLTFNNTSE-- 376

  Fly   471 RRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIA-----LALRAAEE------------------- 511
                   .:..|.:..|:|:.....|:||:|:|     |.|...|.
Mouse   377 -------WTALHKYDMALSEEGYNLYNAVYAVAHTYHELILLQVESQQMAVPKGTFTDCQQVSSM 434

  Fly   512 --------------HWRRNEEQ-SKLDGFDYTRSDMAWEFLQQMG----------------KLHF 545
                          :.:..|.| :..|.|      :.|.|.|.:|                :||.
Mouse   435 LKSRIFTNPVGELVNMKHRENQCADYDIF------IIWNFSQGLGLKVKIGSYLHCYPRSQQLHI 493

  Fly   546 L--------GVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYP---------ATDALDF-RCPR 592
            .        |.|.|.|..  ....|..|.:|.:.  |.....:.         :.:..|. :|.|
Mouse   494 SEDLEWVTGGSSVPSSMC--SMTCTAGFRKIHQN--ETADCCFDCVQCPENEVSNETADMEQCVR 554

  Fly   593 CRPVKW------HSGQVPIAKRVFK--LRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKL 649
            |...|:      |..|..::...::  |.:| :..:|.:    ||::.:.:.:.|    :.::..
Mouse   555 CPDDKYANLEKTHCLQRAVSFLAYEDPLGIA-LGCMALF----LSALTVLVLVTF----VKYKDT 610

  Fly   650 KAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMF 714
            ..:|.::..||.|..:..:|.:...:|. :.|..        ...|..:.......|::|..::.
Mouse   611 PIVKANNRILSYILLISLVFCFLCSLLF-IGHPN--------QATCILQQTTFGVFFTVAISTVL 666

  Fly   715 AKTYRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP--MERHLHNLTLE 775
            |||..|...|  |..|...:. ||......|::....|:..:...:|:||.|  ::|
Mouse   667 AKTITVLMAFKLTTPGRRMRG-MLASGAPNLVIPICTLIQLVFCGIWLVTSPPFIDR-------- 722

  Fly   776 ISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSV 840
                |....|...:.:|.......:..|| .|.|.|.:....:|:..|::. ...|:::::..|:
Mouse   723 ----DTQSEYGKTIIICNKGSVIAFHFVL-GYLGSLALGSFTVAFLARNLP-DRFNEAKFLTFSM 781

  Fly   841 YSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARND 896
              :|..|..:..|....|.|.|:..:.....||.|:...|..:|:||...|..|.|
Mouse   782 --LVFCSVWITFLPVYHSTRGTVMVVVEVFSILASSAGLLGCIFLPKCCVILVRLD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	90/516 (17%)
		ANF_receptor	174..568	CDD:279440	87/484 (18%)
		7tm_3	633..889	CDD:278433	52/259 (20%)
Vmn2r11	NP_001372097.1	PBP1_pheromone_receptor	45..499	CDD:380588	81/459 (18%)
		NCD3G	507..561	CDD:400103	11/57 (19%)
		7tmC_V2R_pheromone	581..832	CDD:320410	58/285 (20%)
		TM helix 1	582..606	CDD:320410	6/32 (19%)
		TM helix 2	618..639	CDD:320410	5/21 (24%)
		TM helix 3	648..670	CDD:320410	4/21 (19%)
		TM helix 4	696..712	CDD:320410	2/15 (13%)
		TM helix 5	739..762	CDD:320410	5/23 (22%)
		TM helix 6	774..796	CDD:320410	4/23 (17%)
		TM helix 7	801..826	CDD:320410	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910