DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R3 and gabbr1a

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_694497.5	Gene:	gabbr1a / 373873	ZFINID:	ZDB-GENE-030904-5	Length:	988	Species:	Danio rerio

Alignment Length:	944	Identity:	268/944 - (28%)
Similarity:	433/944 - (45%)	Gaps:	162/944 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 KIVLLGLFELSTSRGPRPDGLSELGAATMAVEHI-NRKRLLPGYTLELVTNDTQCDPGVGVDRFF 215
            |:.:..||.:|   |..|.|.:.|.||.||::.: ||..:||.|.|||:..|:.||||......:
Zfish   166 KLYIGALFPMS---GGWPGGQACLPAAQMALDLVNNRSDILPDYELELIHYDSMCDPGEATKLLY 227

  Fly   216 HAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSS 280
            ..:||:| .::|::.|  ||.|:..:|:....||::..|:||:|||||:|:.||.|:||....:.
Zfish   228 DLLYTEP-IKIVLMPG--CSSVSTLVAEAARMWNLIVFSYGSSSPALSNRQRFPTFFRTHPSATL 289

  Fly   281 HNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRE 345
            |||.|:...:|:.|..:.|..|..||.:..:::|...::.|||..:...:| .||....:..|:.
Zfish   290 HNPTRVRLFQKWEWTKIATIQQTTEVFTSTLDDLEERVKEANIEISVRQSF-LTDPAVAVKNLKR 353

  Fly   346 TDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENL- 409
            .|.|||:|.|.:..|.::.||.::.:::|..|.|.|   :|  |:.|......:..:...|||:
Zfish   354 QDARIIVGLFYETEARKVFCEVFKEKLYGKKYVWFL---IG--WYADNWFKIKDPAINCTVENMT 413

  Fly   410 ----------IVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQ 464
                      ||:....::.|    .|.|.:..|.:||..:
Zfish   414 EAVEGHITTEIVMLNPETVRG----ASNLTSQEFIAQLMSR------------------------ 450

  Fly   465 SDSRRRRRRGVGGTSGGHLFPEAIS--QYAPQTYDAVWAIALALRAA-----EEHWRRNEEQSKL 522
                      :||.:     ||...  |.||..||||||:||||...     .:.|       .|
Zfish   451 ----------LGGKN-----PEETGGFQEAPLAYDAVWALALALNKTVAPLRAKGW-------GL 493

  Fly   523 DGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGP-DRVGTTAFYQIQRGLLEPVALYYPATDAL 586
            :.|:|...::..|..:.:....|.||||.|.|... .|:..|...|:|.|..:.:. ||.:|..
Zfish   494 EDFNYNNKEITAEIYRALNTSSFEGVSGHVVFDAQGSRMAWTLIEQLQGGSYKKIG-YYDSTKG- 556

  Fly   587 DFRCPRCRPVKWHS-----GQVPIA--KRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNL 644
                    .:.|:.     |..|.|  .:|.| ....::...|.:::..:.:||.|.|..|:||:
Zfish   557 --------NLSWYGNDKWIGLSPPADQTKVIK-EFRYLSQKLFVSVSVFAGLGILLGIVCLSFNI 612

  Fly   645 HFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLA 709
            :...::.|:.|.|.|:|:|||||:...|.|..||:|  .|......|..||..|::||..|||||
Zfish   613 YNSSVRYIQNSQPYLNNMTAVGCVLALAAVFPLGID--GLHVRRSQFPVVCQFRLWLLGLGFSLA 675

  Fly   710 FGSMFAKTYRVHRIFTRTGSVFKD------KMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERH 768
            :||||.|.:.||.:||:     ||      |.|:..:|...|..||.:|.|.:.:|.:.||:...
Zfish   676 YGSMFTKIWWVHTVFTK-----KDEKKEKRKHLEPWKLYATVAVLLAIDVLSLLIWQIMDPLHIT 735

  Fly   769 LHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDS 833
            :...|.|....|..|:.||.:|.|.|:...|||.|:|.||||||::|:::|:||:.:....:||.
Zfish   736 VEQFTKEAPKEDLDVLIQPLLEHCSSKKMNTWLGVVYGYKGLLLLLGIFLAYETKSISTEKINDH 800

  Fly   834 QYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDII 898
            :.:|:::|:|.:...|...:..::|.:...:|...:..|:.|...||.:||:||:..:..|.:..
Zfish   801 RAVGMAIYNVAVLCMITAPVTMILSSQQDASFAFASLAIIFSVYITLVVLFVPKIRRLITRGEWQ 865

  Fly   899 DPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTT 963
            .....::......|..    |:.:..|  :|.:||..:|.||      .|.||:.|
Zfish   866 SEQQDTLKTGSSTNNN----DEEKSRQ--LERENRELQKIIQ------EKEERVTE--------- 909

  Fly   964 TSSSTSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILPNLLLSV-LPPVIPRASWPSAEY 1027
                               :.|.:::..|....|.||:..  .|...|| .|...|.:..|:.:.
Zfish   910 -------------------LRSQLAERQALRSRRRPSVQN--QNQNHSVPSPQADPPSYCPTTDK 953

  Fly  1028 MQIPMRRSVTFASQPQL--EEACLPAQDLINLRL 1059
            ..:|    .:|::...|  .|:.|...:..|.||
Zfish   954 QSMP----PSFSNSSNLYQGESKLSRNNCHNSRL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	131/452 (29%)
		ANF_receptor	174..568	CDD:279440	119/413 (29%)
		7tm_3	633..889	CDD:278433	95/261 (36%)
gabbr1a	XP_694497.5	CCP	98..155	CDD:214478
		PBP1_GABAb_receptor	168..561	CDD:107361	131/464 (28%)
		ANF_receptor	184..541	CDD:279440	120/415 (29%)
		7tm_3	601..855	CDD:278433	94/260 (36%)
		Ax_dynein_light	<883..925	CDD:287215	13/77 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820