DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and mtt

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster

Alignment Length:	1346	Identity:	281/1346 - (20%)
Similarity:	472/1346 - (35%)	Gaps:	385/1346 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 YKRTKVKRRQQRLNSH-----SNL------------------PGSTNASHAHHLLN--------- 121
            |:..::::||||:..|     |:|                  |.:.:.::.|..|.
  Fly   261 YEMLELEQRQQRMGKHWRQWMSHLQSPDYANDDPLPDGRRSSPANADLTYDHFELEDYQRYANID 325

  Fly   122 -LPPRQ-----RYLKVNQV------------------------FESERRMSPAEMQRN------- 149
             ..||.     |:|.:|.:                        |::: |:...:.||:
  Fly   326 LASPRSGRHRGRHLPLNNMNLMLPLSSADGSGKYLRSLPDSVSFQND-RLYATQPQRHWPVKREA 389

  Fly   150 --HGKIVLLGLF-----ELSTSRGP-RPD-GLSELGAATMAVEHINRKRLLPGYTLELVTNDTQC 205
              .|.::|.||.     |.|.:.|| .|. |:..|.|....::.|||::|||..||.....| .|
  Fly   390 IVEGDVILGGLMMVHSREDSITCGPIMPQGGIQALEAMLFTIDRINREQLLPNITLGAHILD-DC 453

  Fly   206 DP---GVGV-------------DRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVS 254
            |.   |:.:             |..:|...||....:..::|:|.|..:..:|.::..:.|.|||
  Fly   454 DKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVS 518

  Fly   255 FGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVT-----------TFSQNEEVHS 308
            :.||||.||:::.|.||.||:..|.....|.:..:::.||..|:           .|.:.||:
  Fly   519 YFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEEL-- 581

  Fly   309 LAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMF 373
            ||.:|:...::...:..:......|.|...|.||.:......||....||:. |::....|....
  Fly   582 LARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVR-QVMRAVRRANAT 645

  Fly   374 GADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTH-NSIVGNNVSYSGLNNHMFNSQL 437
            |: ::||     |:..|..:.....::|.:  ||..:.|... |.:.|....:..|.  :.|:|.
  Fly   646 GS-FSWI-----GSDGWSARNLVSDDYEPE--VEGTLSVQPQANPVRGFEEYFLSLT--VENNQR 700

  Fly   438 RKQSAQFHGQDGFGSGYGSRISIA----ATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDA 498
            .....:| .:|.|...|....|..    ..|..::.|..|  ..|.    |.:.: |:..   ||
  Fly   701 NPWFVEF-WEDHFQCRYPGSTSTPYNNYTKQCTTKERLSR--QNTD----FEDQL-QFVS---DA 754

  Fly   499 VWAIALALRAAEEHWRRN---------EEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPV-- 552
            |.|.|.|||  :.|  |:         |......|.|         .|:.:.|:.|.|:||..
  Fly   755 VMAFAYALR--DMH--RDLCGGGPSLCEAMKPTKGAD---------LLKYLRKVEFEGLSGDEFR 806

  Fly   553 ---SFSGPDRVGTTAFYQIQRG-------------------------LLEP-------------- 575
               :..||.|.....|.|.|.|                         .|.|
  Fly   807 FDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVG 871

  Fly   576 VALYYPATDALDFRCPRCRPVKWHS------------GQVPIAKRVFKLRVATI--APLAFYTIA 626
            .|..|...::..:.|..|...:...            |.:|.|.:.:...:..|  .|.:.:.|.
  Fly   872 QAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIG 936

  Fly   627 TL--SSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAED 689
            .:  |:.||.:.:..:...:.......::.|..:||.|...|....|.....|.|..:.:
  Fly   937 AMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNI----- 996

  Fly   690 SFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTG--SVFKDKMLQDIQLILLVGGLLLVD 752
                ||..:.:.:...|::.:.::..||.|:.||| :.|  |..:...:.....:::...|:.|.
  Fly   997 ----VCAIQRFGVGFCFTVVYAALLTKTNRIARIF-KAGKQSAKRPSFISPKSQLVICACLVSVQ 1056

  Fly   753 ALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVY 817
            .|:..:|:|..|.....|..|.|           ..:.||.|....::: :.::|...|:|:...
  Fly  1057 ILINGVWMVIAPSHAMHHYPTRE-----------DNLLVCDSYIDASYM-IAFSYPIFLIVICTV 1109

  Fly   818 MAWETRHVKIP-ALNDSQYIGVSVYSVVITSAIVVVL----ANLISERVTLAFITITALILTSTT 877
            .|..||  ||| |.|:|::||.::|:..:.....|.|    ||.:..|:|...:||:    .|.:
  Fly  1110 YAVLTR--KIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTIS----LSAS 1168

  Fly   878 ATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQAL 942
            .|:..||.|||:.|     :|.|         |.|.|:.::..|....:|..............:
  Fly  1169 VTIACLFSPKLYII-----LIRP---------ERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVV 1219

  Fly   943 DAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILPN 1007
            .|.....|..::..:|.|:|..|..|..|                      .:..|.:||.|:.:
  Fly  1220 TAATCAQEEKIQKHITPTNTENSLKTKKL----------------------CEMATQTISSIITS 1262

  Fly  1008 LLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQ--PQLEEACLPAQDLINLRLAHQQATEAKTG 1070
            |.::.              |.|||      :|.|  |.            |...|....|:..:|
  Fly  1263 LDINA--------------YNQIP------YADQYVPN------------NATTATTTPTDKGSG 1295

  Fly  1071 LINRLRGIFSRTTSSNKGSTASLADQKGLKAAFKSHMGLFTRLIPSSQTASCNAIYNNP--NQDS 1133
            ..|      |.:.|:..||:.|.::..|                 ....|:...:.||.  ||
  Fly  1296 NGN------SNSNSNTNGSSNSNSNSNG-----------------DGDVATEQVVANNNKINQ-- 1335

  Fly  1134 IPSEASSHPNGNHLKPIHRGSLTKSGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVKLLET- 1197
                      ..|.:|....::|.:..|:    ..|......|.:.||...:.|.......|.|
  Fly  1336 ----------RQHGQPAVAFAITSTNNHI----SGPAATITTTAATGETTTEALVATITTPLATV 1386

  Fly  1198 ---KVNFQLPSN-------RRPSVVQ----------QPPSLRERVR 1223
               :.....|:|       :||.|:|          |...|:|:.|
  Fly  1387 DGSETMSVAPNNGHGNNGSQRPPVLQTNLXLNAQQLQQQLLKEQQR 1432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	122/524 (23%)
		ANF_receptor	174..568	CDD:279440	107/439 (24%)
		7tm_3	633..889	CDD:278433	61/262 (23%)
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	120/491 (24%)
		ANF_receptor	422..820	CDD:279440	106/435 (24%)
		NCD3G	861..910	CDD:284890	4/48 (8%)
		7tm_3	945..1181	CDD:278433	62/263 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910