DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R3 and GABA-B-R1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	870	Identity:	254/870 - (29%)
Similarity:	430/870 - (49%)	Gaps:	93/870 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 GLFELSTSRGPRPDGLSELGAATMAVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYT 220
            |:|.:: .:|....|.:.:.||.:|::.:|:: .||||:.|.|.:||::|:||:|....::.:|.
  Fly    37 GIFPIA-GKGGWQGGQACMPAARLALDDVNKQPNLLPGFKLILHSNDSECEPGLGASVMYNLLYN 100

  Fly   221 QPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPAR 285
            :|. ::::|.|  ||.|..::|:....||::.:.:|::|||||||:.||..:||....:.|||.|
  Fly   101 KPQ-KLMLLAG--CSTVCTTVAEAAKMWNLIVLCYGASSPALSDRKRFPTLFRTHPSATVHNPTR 162

  Fly   286 IAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRI 350
            |..::||||..|....|.|||....|.:|......|.:......:| .:|..:.:..||..|.||
  Fly   163 IKLMKKFGWSRVAILQQAEEVFISTVEDLENRCMEAGVEIVTRQSF-LSDPTDAVRNLRRQDARI 226

  Fly   351 IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPD---------QRTACSNHELQLAV 406
            |:|.|....|.::|||.|:.:::|..:.|..   :|  |:.|         :...|:..::::|.
  Fly   227 IVGLFYVVAARRVLCEMYKQQLYGRAHVWFF---IG--WYEDNWYEVNLKAEGITCTVEQMRIAA 286

  Fly   407 ENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRR 471
            |..:..........|..:.||:....|..:|.:...:        .||           |....|
  Fly   287 EGHLTTEALMWNQNNQTTISGMTAEEFRHRLNQALIE--------EGY-----------DINHDR 332

  Fly   472 RRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEF 536
                        :||.. |.||..|||||::|||.....|  |....:..|..|.||..::|.|.
  Fly   333 ------------YPEGY-QEAPLAYDAVWSVALAFNKTME--RLTTGKKSLRDFTYTDKEIADEI 382

  Fly   537 LQQMGKLHFLGVSGPVSFSGP-DRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHS 600
            ...|....||||||.|:||.. ||:..|...|:..|..|.:..|....|.|.:    ....:|..
  Fly   383 YAAMNSTQFLGVSGVVAFSSQGDRIALTQIEQMIDGKYEKLGYYDTQLDNLSW----LNTEQWIG 443

  Fly   601 GQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAV 665
            |:||..:.:....:.|::...|..:.|:||.||.:|.|.:.||:..:..:.|:.|.|..:.|...
  Fly   444 GKVPQDRTIVTHVLRTVSLPLFVCMCTISSCGIFVAFALIIFNIWNKHRRVIQSSHPVCNTIMLF 508

  Fly   666 GCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSV 730
            |.|....:|||||:|...:  :.:.:..:|.||.:|||.||:||:|:||:|.:|||| ||.....
  Fly   509 GVIICLISVILLGIDGRFV--SPEEYPKICQARAWLLSTGFTLAYGAMFSKVWRVHR-FTTKAKT 570

  Fly   731 FKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLE--ISATDRSVVYQPQVEVCR 793
            ...|.::..:|..:|.|||.:|.:::..|.:.||::|:|....||  :|.|| .:..:|::|.|.
  Fly   571 DPKKKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLETFPLEDPVSTTD-DIKIRPELEHCE 634

  Fly   794 SQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLIS 858
            ||....||.::|.:|||:||.|:::|:|||.:|:..:|||:|:|:|:|:||:...|...:..:|:
  Fly   635 SQRNSMWLGLVYGFKGLILVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITAPVGMVIA 699

  Fly   859 ERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMG-LKMECNTRRFVVDDRR 922
            .:...:|..:...::.....::.|:|:||         :|:.:.|... .:.:.|....:..:..
  Fly   700 SQQDASFAFVALAVIFCCFLSMLLIFVPK---------VIEVIRHPKDKAESKYNPDSAISKEDE 755

  Fly   923 ELQYRVEVQNRVYKKEIQALDAEIRKL-ERLLESG-------------LTTTSTTTSSSTSLLTG 973
            |...::..:|...::.|...:.:||.| :||:|.|             .:....|||...||:..
  Fly   756 ERYQKLVTENEELQRLITQKEEKIRVLRQRLVERGDAKGTELNGATGVASAAVATTSQPASLINS 820

  Fly   974 GGHLKPELTVTSGISQTPAASKNRT 998
            ..|..|..|    ::.|....::||
  Fly   821 SAHATPAAT----LAITQDTHEHRT 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	131/443 (30%)
		ANF_receptor	174..568	CDD:279440	121/404 (30%)
		7tm_3	633..889	CDD:278433	89/257 (35%)
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361	131/447 (29%)
		ANF_receptor	52..415	CDD:279440	121/405 (30%)
		7tm_3	476..730	CDD:278433	89/266 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I3495
eggNOG	1	0.900	-	-		E1_KOG1055
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3553
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15091at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10519
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870