DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vom2r4

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001092928.1	Gene:	Vom2r4 / 308248	RGDID:	1564110	Length:	841	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	147/766 - (19%)
Similarity:	250/766 - (32%)	Gaps:	233/766 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 TESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQ 302
            |.|| |:..|....::.|||.:|.|||..:|||.|:....|:......::.:..|||..:.....
  Rat   150 TTSL-KLSIYSRTPKIFFGSFNPNLSDHDQFPYIYQRANKDTYLFCGMVSLMFHFGWTWIGLVIS 213

  Fly   303 NEEVHSLAVNNLVTELEAANISCAATITFAAT--------DFKEQLLLLRETDTRIIIGSFSQEL 359
            |::.....:::|..|::...|..|..|....|        ...:|.|:.......:|.|..:..|
  Rat   214 NDDQGIQFLSDLREEMQRHAICLAFVIMIPETMQIYKTRVKIYDQQLMTSSAKVVVIYGEMNSTL 278

  Fly   360 APQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSI-VGNN- 422
            .......||    .||...||....     | |..|...:..|..:...:.....||.| :..|
  Rat   279 ELSFRRWAY----LGAQRIWITTSQ-----W-DVITNQKDFSLDFSHGTVTFAHHHNDITIFRNF 333

  Fly   423 ------------VSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGV 475
                        :|.|.|..:.||..:.|...:   .|.|  .:.:.:.....
  Rat   334 MQTINTSKYPIDISQSMLQWNHFNCSISKNKKK---MDCF--TFNNPLEWLVQ------------ 381

  Fly   476 GGTSGGHLFPEAISQYAPQTYDAVWAIA-----LALRAAE------------------------- 510
                  |.|...:|:.....|:||:|:|     |..:.||
  Rat   382 ------HTFDMVLSEEGYNLYNAVYAVAHTYHELIFQQAESQKMADPKGVFTDCQQVASLLKTRV 440

  Fly   511 ------EHWRRNEEQ---SKLDGFDYTRSDMAWEFLQQMG----------------KLHF----- 545
                  |....|.::   :|.|.|      :.|.|.|.:|                :||.
  Rat   441 FINPVGELVNMNHKENYCAKYDIF------IIWYFPQGLGLKVKIGSYFPCLPQSQQLHISEDWE 499

  Fly   546 ------LGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVK------- 597
                  |..|...|      |..||.::         .::...|....|.|.:|:..:
  Rat   500 WVTEETLVPSSVCS------VTCTAGFR---------KIHQKQTADCCFDCVQCQENEIANDTDM 549

  Fly   598 WHSGQVP------IAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFN----------LHF 646
            .|..:.|      :.:.....||.|.       :|....:|:||....|:|:          :.:
  Rat   550 EHCVRCPEDSYANLEQTECLQRVVTF-------LAYEDPLGMALGCMALSFSAITILVLVTFVKY 607

  Fly   647 RKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFG 711
            |....:|.::..||.|..:...|.:...:|. :.|..        ...|..:....:..|::|..
  Rat   608 RDTPIVKANNRILSYILLISLAFCFLCSLLF-IGHPN--------QATCILQQTTFAIFFTVAIS 663

  Fly   712 SMFAKTYRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTL 774
            ::.|||..|...|  |..|...:..|::. .:.||:....|:..:|..:|:||.|
  Rat   664 TVLAKTITVVTAFKLTTPGRRIRKMMIKG-AINLLIPICTLIQLVLCAIWLVTSP---------- 717

  Fly   775 EISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVS 839
              ...||.:         :|:|.:.   ::...||.::...:.:.               |:|
  Rat   718 --PFIDRDI---------QSEHGKI---IIICNKGSVIAFHIVLG---------------YLG-- 751

  Fly   840 VYSVVITSAIVVVLANLISERVTLA-FITITALILTSTTATLCLLFIPKLH 889
              |:.:.|..|..||..:.:|...| |:|.:.|:..|...|    |:|..|
  Rat   752 --SLALGSFTVAFLARNLPDRFNEAKFLTFSMLVFYSVWIT----FLPVYH 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	84/439 (19%)
		ANF_receptor	174..568	CDD:279440	82/417 (20%)
		7tm_3	633..889	CDD:278433	53/268 (20%)
Vom2r4	NP_001092928.1	PBP1_Pheromone_receptor	40..500	CDD:107360	76/389 (20%)
		NCD3G	509..560	CDD:284890	11/65 (17%)
		7tm_3	595..829	CDD:278433	50/259 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910