DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and GRM8

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001358015.1	Gene:	GRM8 / 2918	HGNCID:	4600	Length:	928	Species:	Homo sapiens

Alignment Length:	1002	Identity:	207/1002 - (20%)
Similarity:	362/1002 - (36%)	Gaps:	312/1002 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 MQRNH-----------GKIVLLGLFELST--SRG------PRPDGLSELGAATMAVEHINR-KRL 190
            |||.|           |.|:|.|||.:..  .||      .:..|:..|.|...|::.||: ..|
Human    28 MQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDL 92

  Fly   191 LPGYTL--------------------------ELVTNDTQC---DPGVGVDRFFHAIYTQPSTRM 226
            |...||                          |...:|.:|   ||         .|:|:|. ::
Human    93 LSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDP---------PIFTKPD-KI 147

  Fly   227 VMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRK 291
            ..::|:|.|.|:..:|.::..:.|.|:|:.||:|.|||...:.:|.|.|.|||....|.:..:..
Human   148 SGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTA 212

  Fly   292 FGWGTVTTFSQN---EEVHSLAVNNLVTELEAANISCAATITFAAT--DFKEQLLLLRET-DTRI 350
            .||..|:|.:..   .|....|...:..|:....|:.:..|.....  :|::.:..|.|| :.|.
Human   213 LGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277

  Fly   351 IIGSFSQELAPQILCEAYRLRMFGADYAWILHESMG---APWWPDQRTACSNHELQLAVENLIVV 412
            :|...:::...:||..|.:|...| .:.||..:|.|   ||.:..:..|          |..:
Human   278 VIMFANEDDIRRILEAAKKLNQSG-HFLWIGSDSWGSKIAPVYQQEEIA----------EGAV-- 329

  Fly   413 STHNSIVGNNVSYSGLNNH-----MFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRR 472
                :|:....|..|.:.:     :.|::.....|:| .::.||...||.     .:.:|..::.
Human   330 ----TILPKRASIDGFDRYFRSRTLANNRRNVWFAEF-WEENFGCKLGSH-----GKRNSHIKKC 384

  Fly   473 RGVGGTSGGHLFPEAI---SQYAPQ-----TYDAVWAIALALRAAEEHWRRNE----------EQ 519
            .|:          |.|   |.|..:     ..|||:::|.||     |....:          ..
Human   385 TGL----------ERIARDSSYEQEGKVQFVIDAVYSMAYAL-----HNMHKDLCPGYIGLCPRM 434

  Fly   520 SKLDGFDYTRSDMAWEFLQQMGKLHFLGVSG-PVSFS-GPDRVGTTAFYQIQ------------- 569
            |.:||         .|.|..:..::|.|.:| ||:|: ..|..|....:|.|
Human   435 STIDG---------KELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGH 490

  Fly   570 ----------------RGLLEPVAL----------------------------YYPATDALDFRC 590
                            |....|.::                            |....|.|.  |
Human   491 WTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELS--C 553

  Fly   591 PRC----RP--------------VKWHS--GQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIAL 635
            ..|    ||              ::|||  ..||:...:..:...|.                 :
Human   554 ELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF-----------------V 601

  Fly   636 AIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVY 700
            .:.|:.:|    ....::.|..:||.:...|....|:...|       :.:|.|:.  :|:.|..
Human   602 IVTFVRYN----DTPIVRASGRELSYVLLTGIFLCYSITFL-------MIAAPDTI--ICSFRRV 653

  Fly   701 LLSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP 764
            .|..|...::.::..||.|:||||.: ..||...|.:.....:::...|:.|..|.|.:|.|.||
Human   654 FLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDP 718

  Fly   765 ------------MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVY 817
                        ::.......|:...:|.|:       :|.           ..|..||:|....
Human   719 PHIIIDYGEQRTLDPEKARGVLKCDISDLSL-------ICS-----------LGYSILLMVTCTV 765

  Fly   818 MAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVLANLI--SERVTLAFITITALILTSTTAT 879
            .|.:||.|. ...|:::.||.::|:. :|..|.:.:.....  :|::.:...|:|..:..|.:.:
Human   766 YAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVS 829

  Fly   880 LCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEV-----QNRVYKKEI 939
            |.:|::||::.|         :.|.     |.|.:      :|:..::..|     |:::.:|..
Human   830 LGMLYMPKVYII---------IFHP-----EQNVQ------KRKRSFKAVVTAATMQSKLIQKGN 874

  Fly   940 QALDAEIRKLERLLESGLTTTSTTTSS 966
            ...:.|::  ..|.|| |.|.|:|..|
Human   875 DRPNGEVK--SELCES-LETNSSTDES 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	115/561 (20%)
		ANF_receptor	174..568	CDD:279440	102/457 (22%)
		7tm_3	633..889	CDD:278433	58/271 (21%)
GRM8	NP_001358015.1	PBP1_mGluR_groupIII	40..504	CDD:380599	113/520 (22%)
		Glutamate binding. /evidence=ECO:0000250	177..179		0/1 (0%)
		NCD3G	512..562	CDD:369426	6/51 (12%)
		7tmC_mGluR8	582..892	CDD:320570	74/381 (19%)
		TM helix 1	583..607	CDD:320570	4/40 (10%)
		TM helix 2	619..640	CDD:320570	5/27 (19%)
		TM helix 3	649..671	CDD:320570	4/21 (19%)
		TM helix 4	697..713	CDD:320570	4/15 (27%)
		TM helix 5	745..768	CDD:320570	7/40 (18%)
		TM helix 6	777..802	CDD:320570	6/24 (25%)
		TM helix 7	812..837	CDD:320570	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910