Protein Alignment GABA-B-R3 and GRM7

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_870989.1
• Gene: GRM7 / 2917
• HGNCID: 4599
• Length: 922
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 203/1027 - (19%)
• Similarity: 374/1027 - (36%)
• Gaps: 283/1027 - (27%)

  Fly   148 RNHGKIVLLGLFELSTSRGP---------RPDGLSELGAATMAVEHINR-KRLLPGYTL------ 196
            |..|.:.|.|||.:. ::||         |.:|:..|.|...|::.||. ..|||..||
Human    44 RIEGDVTLGGLFPVH-AKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILD 107

  Fly   197 --------------------ELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESL 241
                                :..|:|.:|..|.      ..::.:|. ::|.::|::.|.|:..:
Human   108 TCSRDTYALEQSLTFVQALIQKDTSDVRCTNGE------PPVFVKPE-KVVGVIGASGSSVSIMV 165

  Fly   242 AKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEV 306
            |.::..:.|.|:|:.||:|.|||.|.:.:|.|.|.|||....|.:..::..||..|:|.:.....
Human   166 ANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSY 230

  Fly   307 HSLAVNNLVTEL--EAANISCAATITF------AATDFKEQLLLLRET-DTRIIIGSFSQELAPQ 362
            ....|.:. |::  ||..:..|.::..      ...||...:..|.:| ::|.::...:.|...|
Human   231 GEKGVESF-TQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQ 294

  Fly   363 ILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSG 427
            ||..|.|....| .:.|:..:|.|:...|       .|:.:...|..|.:....:.|      .|
Human   295 ILAAAKRADQVG-HFLWVGSDSWGSKINP-------LHQHEDIAEGAITIQPKRATV------EG 345

  Fly   428 LNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRG---VGGTSGGHLFPEAIS 489
            .:.:..:..|..........:.:...:..:::|:.::.:...|:..|   :|..|  :...|...
Human   346 FDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDS--NYEQEGKV 408

  Fly   490 QYAPQTYDAVWAIALALRAAEEHWRRN---------EEQSKLDGFDYTRSDMAWEFLQQMGKLHF 545
            |:   ..|||:|:|.||    .|..::         .|..:..|         .:.|:.:..::|
Human   409 QF---VIDAVYAMAHAL----HHMNKDLCADYRGVCPEMEQAGG---------KKLLKYIRNVNF 457

  Fly   546 LGVSG-PVSFS-GPDRVGTTAFYQIQ-----------------------------RGL------- 572
            .|.:| ||.|: ..|..|....:|.|                             :|:
Human   458 NGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASV 522

  Fly   573 ----------------------LEPVALYYPATDALDFRCPRC----RPVKWHSG--QVPIAKRV 609
                                  .||...|....|  :..|..|    ||.:..:|  .:||.|..
Human   523 CTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFD--EMTCQHCPYDQRPNENRTGCQDIPIIKLE 585

  Fly   610 FKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATV 674
            :.      :|.|...: .|:.:||...|..:|..:.:.....::.|..:||.:...|....|...
Human   586 WH------SPWAVIPV-FLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIIT 643

  Fly   675 ILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQD 738
            .|:        .|:...| ||:.|...|..|..:::.::..||.|::|||.: ..||...:::..
Human   644 FLM--------IAKPDVA-VCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISP 699

  Fly   739 IQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVE--VCRSQHTQTWL 801
            ...:.:...|:.|..|.|.:|...||     .|:.::.   |......|:..  |.:...|...:
Human   700 TSQLAITSSLISVQLLGVFIWFGVDP-----PNIIIDY---DEHKTMNPEQARGVLKCDITDLQI 756

  Fly   802 SVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVLANLI--SERVTL 863
            .....|..||:|.....|.:||.|. ...|:::.||.::|:. ::..|.:.:.....  :|::.:
Human   757 ICSLGYSILLMVTCTVYAIKTRGVP-ENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820

  Fly   864 AFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRV 928
            ...|:|..:..|.:..|.:|::||::.|         :.|.                    :..|
Human   821 QTTTLTISMNLSASVALGMLYMPKVYII---------IFHP--------------------ELNV 856

  Fly   929 EVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAA 993
            :.:.|.:|..:.|                                       .|::|.:|..|:.
Human   857 QKRKRSFKAVVTA---------------------------------------ATMSSRLSHKPSD 882

  Fly   994 SKN---RTPSISGILPNLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQP 1042
            ..|   :|.....:.||   :.:|||  |.|          :::|||:.:.|
Human   883 RPNGEAKTELCENVDPN---NCIPPV--RKS----------VQKSVTWYTIP 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	108/549 (20%)
		ANF_receptor	174..568	CDD:279440	94/443 (21%)
		7tm_3	633..889	CDD:278433	57/261 (22%)
GRM7	NP_870989.1	PBP1_mGluR_groupIII	47..511	CDD:107371	105/504 (21%)
		ANF_receptor	77..484	CDD:279440	95/446 (21%)
		Glutamate binding. /evidence=ECO:0000250	180..182		0/1 (0%)
		NCD3G	521..567	CDD:284890	6/47 (13%)
		7tm_3	602..847	CDD:278433	57/262 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..895		5/20 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910