DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GABA-B-R3 and GRM1

DIOPT Version :9

Sequence 1:NP_001245826.1 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_001264993.1 Gene:GRM1 / 2911 HGNCID:4593 Length:1194 Species:Homo sapiens


Alignment Length:1358 Identity:259/1358 - (19%)
Similarity:462/1358 - (34%) Gaps:404/1358 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 LNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPD-------------- 170
            ::|.||....||.....|.:|    .:.|..|.:::..||  |....|..:              
Human    16 VSLLPRSPGRKVLLAGASSQR----SVARMDGDVIIGALF--SVHHQPPAEKVPERKCGEIREQY 74

  Fly   171 GLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQC----------------------DPGVGVD 212
            |:..:.|....::.||... |||..||.....|: |                      |...|::
Human    75 GIQRVEAMFHTLDKINADPVLLPNITLGSEIRDS-CWHSSVALEQSIEFIRDSLISIRDEKDGIN 138

  Fly   213 RFFHAIYTQPSTR----MVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYR 273
            |......:.|..|    :..::|...|.|...:..::..::|.|:::.:||..|||:..:.||.|
Human   139 RCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLR 203

  Fly   274 TVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKE 338
            .|..|:....|.:..::::.| |..:....|..:..:..:...||.|....|.|......::..|
Human   204 VVPSDTLQARAMLDIVKRYNW-TYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGE 267

  Fly   339 QLL--LLRETDTRI----IIGSFSQELAPQILCEAYR-------LRMFGADYAWI---------- 380
            :..  |||:...|:    ::..|.:.:..:.|..|.|       ..:.|:| .|.          
Human   268 KSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSD-GWADRDEVIEGYE 331

  Fly   381 ---------------------------LHESMGAPWWPD--------------------QRTACS 398
                                       |..:...||:|:                    :|....
Human   332 VEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTG 396

  Fly   399 NHELQLAVENLIVVSTHNSIVGNNVSYS---GLNNHMFNSQLRKQSAQFHGQDGFGSGY----GS 456
            |..|:   ||.:..|....::  |..|:   ||.|        ...|...|..|.....    ||
Human   397 NESLE---ENYVQDSKMGFVI--NAIYAMAHGLQN--------MHHALCPGHVGLCDAMKPIDGS 448

  Fly   457 RISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSK 521
            ::.....:|        ...|.||..::.:.... ||..||.:                |.:.::
Human   449 KLLDFLIKS--------SFIGVSGEEVWFDEKGD-APGRYDIM----------------NLQYTE 488

  Fly   522 LDGFDYTRSDMAW--------EFLQQMGKLHFLGVSGPV-------SFSGPDRVGTTAFYQIQRG 571
            .:.:||.... .|        ::..||.|      ||.|       ...|..:|       |::|
Human   489 ANRYDYVHVG-TWHEGVLNIDDYKIQMNK------SGVVRSVCSEPCLKGQIKV-------IRKG 539

  Fly   572 LLEPVALYYPATDAL-------DFRCPRCRPVKWH----SGQVPIAKRVFK-LRVATIAPLAFYT 624
               .|:..:..|...       :|.|..|....|.    :|..||..|..: ..:.:|..:||  
Human   540 ---EVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAF-- 599

  Fly   625 IATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAED 689
                |.:||.:.:......:.:|....:|.||.:|..|...|....|.....|....:|      
Human   600 ----SCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTT------ 654

  Fly   690 SFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGS-----VFKDKMLQDIQLILLVGGLL 749
               |.|..:..|:....::.:.::..||.|:.||.  .||     ..|.:.:.....:::...|:
Human   655 ---TSCYLQRLLVGLSSAMCYSALVTKTNRIARIL--AGSKKKICTRKPRFMSAWAQVIIASILI 714

  Fly   750 LVD-ALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVE----VCRSQHTQTWLSVL--YAY 807
            .|. .|:|||.::..||                .::..|.::    :|.:.:    |.|:  ..|
Human   715 SVQLTLVVTLIIMEPPM----------------PILSYPSIKEVYLICNTSN----LGVVAPLGY 759

  Fly   808 KGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVYSV-VITSAIVVVLANLISERVTLAFITITA 870
            .|||::...|.|::||:|  || .|:::||..::|:. :|..|.|.:......:.:|..|    |
Human   760 NGLLIMSCTYYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCF----A 818

  Fly   871 LILTSTTATLCLLFIPKLHDIWAR-----------NDIIDPVIHSMGLKMECNTRRFVVDDRRE- 923
            :.|:.|.|..| :|.||::.|.|:           :|::.  :|....|:.|.:..|:...||: 
Human   819 VSLSVTVALGC-MFTPKMYIIIAKPERNVRSAFTTSDVVR--MHVGDGKLPCRSNTFLNIFRRKK 880

  Fly   924 ----------------------------LQYRVEVQNRVYKKEIQALDAEIRKLERLLE-SGLTT 959
                                        :.:|:.|..:..:..... .|.|:.|.:..: ||.:.
Human   881 AGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQ-TAVIKPLTKSYQGSGKSL 944

  Fly   960 TSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKN-----RTPSISGILPNLLLSVLPPVIPR 1019
            |.:.||:.|.      :...|......|..:|..|.:     |.||         .:..||:   
Human   945 TFSDTSTKTL------YNVEEEEDAQPIRFSPPGSPSMVVHRRVPS---------AATTPPL--- 991

  Fly  1020 ASWPSAEYMQIPMRRSVTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTS 1084
               ||    .:....:..|.::|.|.:...|...      ..||....:..|:::|:|:.|..::
Human   992 ---PS----HLTAEETPLFLAEPALPKGLPPPLQ------QQQQPPPQQKSLMDQLQGVVSNFST 1043

  Fly  1085 SNKGSTASLADQ----KGLKAAF-----KSHMGLFTRLIPSSQTASCNAIYNNPNQDSIPSEASS 1140
            :.....|.||..    .||::.:     ..|:    :::|...:.....:.:.|..|...||   
Human  1044 AIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHL----QMLPLQLSTFGEELVSPPADDDDDSE--- 1101

  Fly  1141 HPNGNHLKPIHRGSLTKSGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVKLLETKVNFQLPS 1205
                       |..|.:...: :|..:           |..:.|:        |.|.:.:.|..|
Human  1102 -----------RFKLLQEYVY-EHERE-----------GNTEEDE--------LEEEEEDLQAAS 1135

  Fly  1206 NRRP--SVVQQPPS-LRERVRGSPRFP-----HRIL--PPTCSLSALAESEDRPGDST 1253
            ...|  |....||| .|:.|......|     ..:|  ||..|.:::...:.:...||
Human  1136 KLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSST 1193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_001245826.1 PBP1_GABAb_receptor 157..590 CDD:107361 101/572 (18%)
ANF_receptor 174..568 CDD:279440 91/512 (18%)
7tm_3 633..889 CDD:278433 62/269 (23%)
GRM1NP_001264993.1 PBP1_mGluR_groupI 36..510 CDD:107369 91/521 (17%)
ANF_receptor 77..485 CDD:279440 80/448 (18%)
Glutamate binding. /evidence=ECO:0000305 186..188 0/1 (0%)
NCD3G 521..570 CDD:284890 9/58 (16%)
7tm_3 604..837 CDD:278433 62/270 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 883..905 0/21 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1173 16/78 (21%)
GluR_Homer-bdg 1144..1194 CDD:287563 12/50 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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