DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Gpr179

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_008766419.1	Gene:	Gpr179 / 287657	RGDID:	1560033	Length:	2309	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	168/804 - (20%)
Similarity:	289/804 - (35%)	Gaps:	227/804 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 LRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVIL 676
            ||.|.:|..|...:|    |.:::.:|:     ..|..|.|:.|...|......|.:.:|..|.:
  Rat   380 LRTAVLACQACCMLA----VFLSMLVAY-----RCRGSKRIRASGIVLLETILFGSLLLYFPVFI 435

  Fly   677 LGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF-TRTGS----VFKDKML 736
            |....|...         |.|..::...||::.:|::..|.|||.::| :||..    ....::|
  Rat   436 LYFKPSVFR---------CVALRWVRLLGFAVVYGTIILKLYRVLQLFLSRTAQRGPHPSSGQLL 491

  Fly   737 QDI-QLILLVGGLLLVDALLVTLWV--VTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQ 798
            |.: ||:|||.|.|:|       |.  |.:|..:|...:|...:.|.|      ...:|...|
  Rat   492 QRLGQLLLLVLGFLVV-------WTAGVLEPGIQHTPLVTRGHTPTGR------HFYLCHHDH-- 541

  Fly   799 TWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITS-----AIVVVLANLIS 858
             |..::...:.|||..|.::.:.||.|. .|.::.:|:.:::::.::.|     |..|::.:|..
  Rat   542 -WDYIMVVAEMLLLCWGSFLCYATRAVP-SAFHEPRYMSIALHNELLLSTAFHTARFVLVPSLHP 604

  Fly   859 ERVTLAFITITALILTSTTATLCLLFIPKLHDIW-----ARNDIID------PVIHSMGLKMECN 912
            :...|.|...|.   ::.|.||.|:||||   .|     .|.:|:|      |.:|..|..:..:
  Rat   605 DWTLLLFFLHTH---STVTTTLALIFIPK---FWKPGAPPREEILDEVYEDEPDLHRSGSYLNSS 663

  Fly   913 TRRF----------VVDDRRELQYRVEVQNRVYKKEIQALDAEIRK-------------LERLLE 954
            ....          :.|:.::|..::||:.   .||:.|.:..:.|             :..|.|
  Rat   664 IASAWSERSLDPGDIRDELKKLYAQLEVRK---TKEMAANNPHLPKKRGSSRQGLGRSFMRYLAE 725

  Fly   955 --SGLTTTSTTTSSSTSLLTGGGHLKPELTVTS--GISQTPAASKNRT-----------PSISGI 1004
              ..|....:..|.|..|.:..|..:..|..:|  |..:.||..|.|:           ||.|.:
  Rat   726 FPEALARQHSRDSGSLGLSSLPGSSRRRLLSSSLQGTEKAPALRKTRSTYEHHREHNTPPSESSL 790

  Fly  1005 LPNLL---------------------------LSV---LPPVIPRASWPSAEYMQIPMRRSVTFA 1039
            ...|.                           |:|   ||...|.:...|...:.....:::..|
  Rat   791 RRTLSKKASPTEGQVSVEGPPALGFRSASAHNLTVGERLPRARPMSLQKSLSVVAGSREKALLVA 855

  Fly  1040 SQPQLEEACLPAQDLINLRLAHQQATEAKTGLINR---------LRGIFSRTTSSNKGSTASLAD 1095
            ||..|||....|::    |...::|..|....:.|         ||...|...|..|.|:
  Rat   856 SQAYLEETYRQAKE----REERKKAEAAMVSPVRRPSARRLEWPLRAPLSAPPSPAKSSS----- 911

  Fly  1096 QKGLKAAFKSHMGLFTRLIPSSQTASCNAIYNNPNQDS---IPSEASSHPNGNHLKPIHRGSLTK 1157
                              :.||.|.      ..|::::   :|     ||      ||.....|
  Rat   912 ------------------MESSHTP------GRPHEEAGRRLP-----HP------PIRHQVST- 940

  Fly  1158 SGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVKLLETKVNFQLPSNRRPSVVQQPPSLRERV 1222
                           ||..:||...|:.       ::|.......|.....|::...|..:...|
  Rat   941 ---------------PILALSGACLGEP-------RMLSPTPTSTLAPVLLPALAPTPTPVLAPV 983

  Fly  1223 RGSPRFPHRILPPTCSLSALAESEDRPGDSTSILGSCKSIPRISLQQATSGGT--WKSMETAGKS 1285
            ...|:.| .:|...|..    |:.:.||...:::....:.|..|.....|..|  |:::..|.:.
  Rat   984 SKPPQSP-TLLTFICPW----ENAELPGKKENVVQEGPAGPERSSHTPASARTKIWRALSVAVEK 1043

  Fly  1286 RLSLGDSQEEEQ----QAPANGTE 1305
            : ..|:|:...:    |..|:.|:
  Rat  1044 K-GTGESEALTEGGHVQGEADDTD 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361
		ANF_receptor	174..568	CDD:279440
		7tm_3	633..889	CDD:278433	67/268 (25%)
Gpr179	XP_008766419.1	7tm_3	392..632	CDD:278433	69/280 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910