Protein Alignment GABA-B-R3 and Grm4

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001277974.1
• Gene: Grm4 / 268934
• MGIID: 1351341
• Length: 912
• Species: Mus musculus
• Alignment Length: 872
• Identity: 195/872 - (22%)
• Similarity: 327/872 - (37%)
• Gaps: 198/872 - (22%)

  Fly   148 RNHGKIVLLGLFELSTSRG---------PRPDGLSELGAATMAVEHINR-KRLLPGYTLELVTND 202
            |..|.|.|.|||.:. .||         .:..|:..|.|...|::.||. ..|||..||.....|
Mouse    44 RIDGDITLGGLFPVH-GRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILD 107

  Fly   203 TQCDPGVGVDRFFHA---------------------------IYTQPSTRMVMLLGSACSEVTES 240
            | |      .|..||                           |.|:|. |:|.::|::.|.|:..
Mouse   108 T-C------SRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPE-RVVGVIGASGSSVSIM 164

  Fly   241 LAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEE 305
            :|.::..:.|.|:|:.||:|.|||...:.:|.|.|..|:....|.:..:|...|..|:|.:....
Mouse   165 VANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGS 229

  Fly   306 VHSLAVNNLVTE-LEAANISCAATITF----AATDFKEQLLLLRETDTRIIIGSFSQELAPQILC 365
            .....|...:.: .|...:..|.::..    ...:|.:.:..|.||.....|..|:.|...:.:.
Mouse   230 YGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARAIIIFANEDDIRRVL 294

  Fly   366 EAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNN 430
            ||.|.......:.|:..:|.|:...|..|       |:...|..:      :|:....|..|.:.
Mouse   295 EAARRANQTGHFFWMGSDSWGSKSAPVLR-------LEEVAEGAV------TILPKRTSVRGFDR 346

  Fly   431 HMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRR---RRGVGGTSGGHLFPEAISQYA 492
            :..:..|..........:.:...:..::|..|.:..|..::   |..:|..|...  .|...|:
Mouse   347 YFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYE--QEGKVQF- 408

  Fly   493 PQTYDAVWAIALALRAAEEHW--RRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSG-PVSF 554
              ..|||:|:..||.|.....  .|.....::|..|.|      :.|:.:..::|.|::| ||:|
Mouse   409 --VIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGT------QLLKYIRNVNFSGIAGNPVTF 465

  Fly   555 S-GPDRVGTTAFYQIQR--GLLEPVALYYPA----TDALDFRCPR------------------CR 594
            : ..|..|....||.||  |..|     |..    ||.|..|..|                  |:
Mouse   466 NENGDAPGRYDIYQYQRRNGSAE-----YKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQ 525

  Fly   595 P------VK-----WH----SG---------------------------QVPIAKRVFKLRVATI 617
            |      ||     ||    :|                           .:||.|..:....| :
Mouse   526 PGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWA-V 589

  Fly   618 APLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHS 682
            .||      .|:.||||..:..:...:.:.....:|.|..:||.:...|....|||..|:
Mouse   590 LPL------FLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLM----- 643

  Fly   683 TLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTR-TGSVFKDKMLQDIQLILLVG 746
               .||....| |:.|...|..|.|:::.::..||.|::|||.: ..||...:.:.....:.:..
Mouse   644 ---IAEPDLGT-CSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITF 704

  Fly   747 GLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVV-YQPQVE--------VCRSQHTQTWLS 802
            .|:.:..|.:.:|.|.||               ..||| :|.|..        |.:...:...|.
Mouse   705 VLISLQLLGICVWFVVDP---------------SHSVVDFQDQRTLDPRFARGVLKCDISDLSLI 754

  Fly   803 VLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSV-VITSAIVVVL--ANLISERVTLA 864
            .|..|..||:|.....|.:||.|. ...|:::.||.::|:. ::..|.:.:.  .:..::::.:.
Mouse   755 CLLGYSMLLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQ 818

  Fly   865 FITITALILTSTTATLCLLFIPKLHDI 891
            ..|:|..:..|.:.:|.:|::||::.|
Mouse   819 TTTLTVSVSLSASVSLGMLYMPKVYII 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	119/531 (22%)
		7tmC_GABA-B-like	621..892	CDD:320175	65/284 (23%)
		TM helix 1	621..645	CDD:320175	5/23 (22%)
		TM helix 2	657..678	CDD:320175	7/20 (35%)
		TM helix 3	696..720	CDD:320175	6/23 (26%)
		TM helix 4	741..761	CDD:320175	3/19 (16%)
		TM helix 5	797..823	CDD:320175	7/25 (28%)
		TM helix 6	832..855	CDD:320175	4/25 (16%)
		TM helix 7	862..887	CDD:320175	5/24 (21%)
Grm4	NP_001277974.1	PBP1_mGluR_groupIII	43..508	CDD:380599	117/501 (23%)
		NCD3G	516..566	CDD:462210	7/49 (14%)
		7tmC_mGluR4	586..912	CDD:320568	68/292 (23%)
		TM helix 1	586..611	CDD:320568	8/31 (26%)
		TM helix 2	623..644	CDD:320568	7/28 (25%)
		TM helix 3	653..677	CDD:320568	6/23 (26%)
		TM helix 4	699..719	CDD:320568	3/19 (16%)
		TM helix 5	749..775	CDD:320568	7/25 (28%)
		TM helix 6	783..806	CDD:320568	4/22 (18%)
		TM helix 7	816..841	CDD:320568	5/24 (21%)