DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and GABBR1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_005249039.1	Gene:	GABBR1 / 2550	HGNCID:	4070	Length:	966	Species:	Homo sapiens

Alignment Length:	871	Identity:	260/871 - (29%)
Similarity:	418/871 - (47%)	Gaps:	97/871 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 RLNSHSNLPGSTNASHAHHLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLG-LFELST 163
            |.:...:|.||:.:..:....:.|  :.:.:||:...||||            .|.:| ||.:|
Human   135 RCDPDFHLVGSSRSICSQGQWSTP--KPHCQVNRTPHSERR------------AVYIGALFPMS- 184

  Fly   164 SRGPRPDGLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMV 227
              |..|.|.:...|..||:|.:|.:| :||.|.|:|:.:|::||||......:..:|..| .:::
Human   185 --GGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDP-IKII 246

  Fly   228 MLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKF 292
            ::.|  ||.|:..:|:....||::.:|:||:|||||:|:.||.|:||....:.|||.|:....|:
Human   247 LMPG--CSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKW 309

  Fly   293 GWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLL---LLRETDTRIIIGS 354
            ||..:.|..|..||.:..:::|...::.|.|.    |||..:.|.:..:   .|:..|.|||:|.
Human   310 GWKKIATIQQTTEVFTSTLDDLEERVKEAGIE----ITFRQSFFSDPAVPVKNLKRQDARIIVGL 370

  Fly   355 FSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWP--DQRTACSNHELQLAVENLIVVSTHNS 417
            |.:..|.::.||.|:.|:||..|.|.|.......|:.  |....|:..|:..|||..|.......
Human   371 FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVML 435

  Fly   418 IVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGH 482
            ...|..|.|.:.:..|..:|.|:                           .:|.....||
Human   436 NPANTRSISNMTSQEFVEKLTKR---------------------------LKRHPEETGG----- 468

  Fly   483 LFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLG 547
                  .|.||..|||:||:||||........|:  ..:|:.|:|....:..:..:.|....|.|
Human   469 ------FQEAPLAYDAIWALALALNKTSGGGGRS--GVRLEDFNYNNQTITDQIYRAMNSSSFEG 525

  Fly   548 VSGPVSF--SGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVF 610
            |||.|.|  || .|:..|...|:|.|..:.:..|....|.|.:    .:..||..|..|..:.:.
Human   526 VSGHVVFDASG-SRMAWTLIEQLQGGSYKKIGYYDSTKDDLSW----SKTDKWIGGSPPADQTLV 585

  Fly   611 KLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVI 675
            ......::...|.:::.|||:||.||:..|:||::...::.|:.|.|.|:|:|||||....|.|.
Human   586 IKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVF 650

  Fly   676 LLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKD------K 734
            .||||...:  ..:.|..||.||::||..||||.:||||.|.:.||.:||:     |:      |
Human   651 PLGLDGYHI--GRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTK-----KEEKKEWRK 708

  Fly   735 MLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQT 799
            .|:..:|...||.|:.:|.|.:.:|.:.||:.|.:.....|....|..|...||:|.|.|:...|
Human   709 TLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNT 773

  Fly   800 WLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLA 864
            ||.:.|.||||||::|:::|:||:.|....:||.:.:|:::|:|.:...|...:..::|.:...|
Human   774 WLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAA 838

  Fly   865 FITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVE 929
            |...:..|:.|:..||.:||:||:..:..|.:.......:|......|      ::..|....:|
Human   839 FAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTN------NNEEEKSRLLE 897

  Fly   930 VQNRVYKKEIQALDAEIRKLERLLES 955
            .:||..:|.|...:..:.:|...|:|
Human   898 KENRELEKIIAEKEERVSELRHQLQS 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	132/441 (30%)
		ANF_receptor	174..568	CDD:279440	119/401 (30%)
		7tm_3	633..889	CDD:278433	95/261 (36%)
GABBR1	XP_005249039.1	Sushi	112..162	CDD:395037	5/28 (18%)
		PBP1_GABAb_receptor	176..575	CDD:380589	134/453 (30%)
		7tmC_GABA-B-R1	595..867	CDD:320418	100/278 (36%)
		TM helix 1	596..620	CDD:320418	11/23 (48%)
		TM helix 2	632..653	CDD:320418	10/20 (50%)
		TM helix 3	669..691	CDD:320418	13/21 (62%)
		TM helix 4	717..733	CDD:320418	5/15 (33%)
		TM helix 5	771..794	CDD:320418	11/22 (50%)
		TM helix 6	807..829	CDD:320418	4/21 (19%)
		TM helix 7	836..861	CDD:320418	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820