DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1225	Identity:	224/1225 - (18%)
Similarity:	386/1225 - (31%)	Gaps:	342/1225 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 AEMQRNHGKIVL-LGLFELSTS----------RGP----RPDGLSELGAA-TMAVEHINRKRLLP 192
            ||....|..:|| |.:..|.|.          ..|    .|..:..|||. .:||:.:|.:.:.|
  Rat    22 AESHAGHSSLVLTLFVVMLMTCLEAAKLTVGFHAPWNISHPFSVQRLGAGLQIAVDKLNSEPVGP 86

  Fly   193 G-YTLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFG 256
            | .:.|....:..|:....:..|...:..:   .:.:|:|.||.|..|.:..:...|:|....|.
  Rat    87 GNLSWEFTYTNATCNAKESLAAFIDQVQRE---HISVLIGPACPEAAEVIGLLASEWDIPLFDFV 148

  Fly   257 STSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLA-VNNLVTELE- 319
            ....||.|..........|.|...........::..||..:..|..:....|.. ||.|...:|
  Rat   149 GQMTALEDHFWCDTCVTLVPPKQEIGTVLRESLQYLGWEYIGVFGGSSAGSSWGEVNELWKAVED 213

  Fly   320 --AANISCAATITFAA--TDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWI 380
              ..:.:..|.:.:::  :|..::.|....:..|:||...|.|.|..||..|..|.:...::.::
  Rat   214 ELQLHFTITARVRYSSGHSDLLQEGLRSMSSVARVIILICSSEDAKHILQAAEDLGLNSREFVFL 278

  Fly   381 LHESMGAPWWPDQRTACSNHELQLAVEN--LIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQ 443
            |.:.:...:|.:..............|:  ||..||:....|::             ..|||..|
  Rat   279 LLQQLEDSFWKEVLAEDKVTRFPKVYESVFLIAPSTYGGSAGDD-------------DFRKQVYQ 330

  Fly   444 FHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALA--- 505
            ...:..|.|...|.                            :.:|.|:...:||:...|..
  Rat   331 RLRRPPFQSSISSE----------------------------DQVSPYSAYLHDALLLYAQTVEE 367

  Fly   506 LRAAEEHWRRNE--------EQSKLDG--------------FDYT-----RSDMAWEFLQQMGKL 543
            :..||:.:|...        :|..|.|              .||:     :|.....||..:...
  Rat   368 MMKAEKDFRDGRQLISTLRADQVTLQGITGPVLLDAQGKRHMDYSVYALQKSGNGSRFLPFLHYD 432

  Fly   544 HFLGVSGP----VSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSGQVP 604
            .|..|..|    ::.|||.  |:...|:...|..|.:....|.|.|               |.
  Rat   433 SFQKVIRPWRDDLNASGPH--GSHPEYKPDCGFHEDLCRTKPPTGA---------------GM-- 478

  Fly   605 IAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLA----------------FNLHFRKLKAIK 653
                       |.:..|.....||..|..|.||..|.                :.:|:..:..:.
  Rat   479 -----------TASVTAVIPTVTLLVVASAAAITGLMLWRLRGKVQNHPGDTWWQIHYDSITLLP 532

  Fly   654 LSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTY 718
            ...|                      .|...|.:..:.:...|.::       |...|| ||||:
  Rat   533 QHKP----------------------SHRGTPMSRCNVSNASTVKI-------SADCGS-FAKTH 567

  Fly   719 RVHRIFTRTGSVF-------------------KDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP 764
            :...:|.....::                   |..:|:::.|:.    .|..:.::....|.|:|
  Rat   568 QDEELFYAPVGLYQGNHVALCYIGEEAEARIKKPTVLREVWLMC----ELKHENIVPFFGVCTEP 628

  Fly   765 MERHLHNLTLEISATDRSVVYQPQVEVCR-SQHTQTW---LSVLY-AYKGLLLVVGV-------- 816
                 .|:.:......:..:    .:|.| |.|...|   ||.:| ...|:|.:.|.
  Rat   629 -----PNICIVTQCCKKGSL----KDVLRNSDHEMDWIFKLSFVYDIVNGMLFLHGSPLRSHGNL 684

  Fly   817 -----------------YMAWETRH---------------------VKIPALNDSQYIGV---SV 840
                             :..||.:|                     .::..|.:..:.|.   .|
  Rat   685 KPSNCLVDSHMQLKLAGFGLWEFKHGSTCRIYNQEATDHSELYWTAPELLRLRELPWSGTPQGDV 749

  Fly   841 YSVVITSAIVVVLANLISERVTLAFITITAL------ILTSTTATLCL-----------LFIPKL 888
            ||      ..::|.:||.::....|..:.|.      .:..:.|.:.|           ..:..:
  Rat   750 YS------FAILLRDLIHQQAHGPFEDLEAAPEEIISCIKDSRAPVPLRPSLLEDKGDERIVALV 808

  Fly   889 HDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQ----NRVYKKEIQALDAEIRKL 949
            ...||.:....|...|:...:...:.|..|.....:..::|:.    ..|.::....|.||.||:
  Rat   809 RACWAESPEQRPAFPSIKKTLREASPRGRVSILDSMMGKLEMYASHLEEVVEERTCQLVAEKRKV 873

  Fly   950 ERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILP-----NLL 1009
            |:||.:.|      .|.....|..|..::||...:..|..:......:..|:|..|.     |.|
  Rat   874 EKLLSTML------PSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDL 932

  Fly  1010 LSVLPPVIPRASWPSAEYMQIPMRRSVTFASQPQLEEACLPAQDLINLRLAHQQATEAKTGLINR 1074
            .|:....|........|                .:.:|.:.|..| .:|...|.|.|..|..::
  Rat   933 YSLFDHTIQTHDVYKVE----------------TIGDAYMVASGL-PIRNGAQHADEIATMSLH- 979

  Fly  1075 LRGIFSRTTSSNKGSTASLADQKGLKAAFKSHMG-LFTRLIPSSQTASCNAIYNNPNQDSIPSEA 1138
               :.|.||:...|.    ..::.||.....|.| :...::..:....|  ::.:....:...|:
  Rat   980 ---LLSVTTNFQIGH----MPEERLKLRIGLHTGPVVAGVVGITMPRYC--LFGDTVNMASRMES 1035

  Fly  1139 SSHPNGNHLKPIHRGSLTKSGTHLDHLTKDPNFLPIPTISGGEQGDQT---LGGK 1190
            ||.|...|:......:|..:|.:  ||.|.      .|||...:|:||   |.||
  Rat  1036 SSLPLRIHVSQSTARALLVAGGY--HLQKR------GTISVKGKGEQTTFWLTGK 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	94/490 (19%)
		ANF_receptor	174..568	CDD:279440	85/437 (19%)
		7tm_3	633..889	CDD:278433	51/361 (14%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	81/432 (19%)
		ANF_receptor	66..417	CDD:279440	74/394 (19%)
		PK_GC	558..832	CDD:270894	45/293 (15%)
		CYCc	868..1058	CDD:214485	46/222 (21%)
		Guanylate_cyc	895..1081	CDD:278633	45/220 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910