DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Grm3

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_008760904.1	Gene:	Grm3 / 24416	RGDID:	2744	Length:	903	Species:	Rattus norvegicus

Alignment Length:	910	Identity:	184/910 - (20%)
Similarity:	309/910 - (33%)	Gaps:	293/910 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GKIVLLGLFELSTSRGPRPD---------GLSELGAATMAVEHINRKR-LLPG-----YTLELVT 200
            |.:||.|||.:: .:|...:         |:..|.|...|::.||:.. ||||     :.|:..:
  Rat    37 GDLVLGGLFPIN-EKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCS 100

  Fly   201 NDT----------------------QCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAK 243
            .||                      .|..|      .:||.......:..::|.:.|.|:..:|.
  Rat   101 RDTYALEQSLEFVRASLTKVDEAEYMCPDG------SYAIQENIPLLIAGVIGGSYSSVSIQVAN 159

  Fly   244 VVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHS 308
            ::..:.|.|:|:.|||..|||:..:.||.|||.||.....|....:|.|.|..|:|.:...:...
  Rat   160 LLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGE 224

  Fly   309 LAVNNLVTELEAANISCAATITFAATDFKEQL-----LLLRETDTRIIIGSFSQELAPQILCEAY 368
            ..:.....|....||..|.......::.::..     .||::.:.|:::.....:.:.:::..|.
  Rat   225 TGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAN 289

  Fly   369 RLRMFGADYAWILHESMGA-------------------------------------------PWW 390
            |:   .|.:.|:..:..||                                           ||:
  Rat   290 RV---NASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWF 351

  Fly   391 PD---QRTACS-----NH----ELQLAVE--------------NLIVVSTH------NSIVGNNV 423
            .|   |:..||     ||    :..||::              |.:....|      .::..|..
  Rat   352 RDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTT 416

  Fly   424 SYSGLNNHMFNSQLRKQ-------SAQFHGQDG---------FGSGYGSRISIAATQSDSRRRRR 472
            ........:...:|.|:       :|.|:...|         ||.|.| |.::...|.
  Rat   417 KLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMG-RYNVFNLQQ------- 473

  Fly   473 RGVGGTSG----GHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMA 533
              .||...    ||                 ||..|:|.....||.||
  Rat   474 --TGGKYSYLKVGH-----------------WAETLSLDVDSIHWSRN----------------- 502

  Fly   534 WEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRG-----LLEPVALYYPATDALDFRCPRC 593
                           |.|.| ...|.........:|.|     :..|...|....|  :|.|..|
  Rat   503 ---------------SVPTS-QCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVD--EFTCMDC 549

  Fly   594 RPVKWH----SGQVPIAKRVFKLRVA-TIAPLAFYTIATLSSVGIALAI-AFLAFNLHFRKLKAI 652
            .|.:|.    ||...:.:...|...| .|.|:   |||.|..:...:.| .|:..|    ....:
  Rat   550 GPGQWPTADLSGCYNLPEDYIKWEDAWAIGPV---TIACLGFLCTCIVITVFIKHN----NTPLV 607

  Fly   653 KLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKT 717
            |.|..:|..|...|....|......    ...||     ..:|..|...|...|::.:.::..||
  Rat   608 KASGRELCYILLFGVSLSYCMTFFF----IAKPS-----PVICALRRLGLGTSFAICYSALLTKT 663

  Fly   718 YRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATD 780
            ..:.|||  .:.|:. :.|.:.....:.:..||:||..::|::|::            ||...|.
  Rat   664 NCIARIFDGVKNGAQ-RPKFISPSSQVFICLGLILVQIVMVSVWLI------------LETPGTR 715

  Fly   781 RSVVYQPQVEV---CRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVY 841
            |..:.:.:..|   |..:.:...:|:  .|..:|:::....|::||  |.|. .|::::||.::|
  Rat   716 RYTLPEKRETVILKCNVKDSSMLISL--TYDVVLVILCTVYAFKTR--KCPENFNEAKFIGFTMY 776

  Fly   842 SVVITSAIVVVLANLISERVTLAFITITALILTST-----TATLCL------------LFIPKLH 889
            :..|               :.|||:.|  ..:||:     |.|:|:            ||.||:|
  Rat   777 TTCI---------------IWLAFLPI--FYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVH 824

Fly 890 889
Rat 825 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	106/574 (18%)
		ANF_receptor	174..568	CDD:279440	95/521 (18%)
		7tm_3	633..889	CDD:278433	60/279 (22%)
Grm3	XP_008760904.1	PBP1_mGluR_groupII	33..494	CDD:380598	95/493 (19%)
		NCD3G	505..555	CDD:400103	12/52 (23%)
		7tmC_mGluR3	575..828	CDD:320564	68/300 (23%)
		TM helix 1	576..600	CDD:320564	8/26 (31%)
		TM helix 2	612..633	CDD:320564	4/24 (17%)
		TM helix 3	642..664	CDD:320564	4/21 (19%)
		TM helix 4	690..706	CDD:320564	5/15 (33%)
		TM helix 5	733..756	CDD:320564	3/24 (13%)
		TM helix 6	768..790	CDD:320564	8/38 (21%)
		TM helix 7	797..822	CDD:320564	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910